Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury

Geng, Fei; Ma, Yanlin; Xing, Tao; Zhuang, Xun; Zhu, Jun; Yao, Lusu

doi:10.1159/000445689

Cited by 24 publications

(19 citation statements)

References 27 publications

(34 reference statements)

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“…The key to clinical treatment is to address the above factors that cause brain damage, prevent or alleviate further damage and promote recovery. The following are the main treatment strategies [51,[101][102][103][104][105]. 1) Rapid and effective cooling is the most important measure for alleviating injury to the central nervous system, and a faster cooling rate is more beneficial for the prognosis of HS patients.…”

Section: Central Nervous System Injury and Brain Protectionmentioning

confidence: 99%

Expert consensus on the diagnosis and treatment of heat stroke in China

et al. 2020

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Heat stroke (HS) is a fatal disease caused by thermal damage in the body, and it has a very high mortality rate. In 2015, the People's Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China, Expert consensus on standardized diagnosis and treatment for heat stroke. With an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years, the 2015 consensus no longer meet the requirements for HS prevention and treatment. It is necessary to update the consensus to include the latest research evidence and establish a new consensus that has broader coverage, is more practical and is more in line with China's national conditions. This new expert consensus includes new concept of HS, recommendations for laboratory tests and auxiliary examinations, new understanding of diagnosis and differential diagnosis, On-site emergency treatment and In-hospital treatment, translocation of HS patients and prevention of HS.

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Section: Central Nervous System Injury and Brain Protectionmentioning

confidence: 99%

Expert consensus on the diagnosis and treatment of heat stroke in China

et al. 2020

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“…Harch et al [7] treated 16 TBI, post-TBI syndrome, and posttraumatic stress disorder (PTSD) patients with 40 sessions of 1.5 ATA/60 minutes of HBOT for 30 days, which greatly improved symptoms, results of neurological examinations, comprehensive IQ tests, and cognition functions. A study by Geng et al [8] showed that HBOT may suppress activation of inflammasome signals, thereby alleviating TBI.…”

Section: Hyperbaric Oxygen Therapy (Hbot) Relieves Tbimentioning

confidence: 99%

Rehabilitation Treatment and Progress of Traumatic Brain Injury Dysfunction

Dang

Chen²,

He³

et al. 2017

Neural Plasticity

104

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Traumatic brain injury (TBI) is a major cause of chronic disability. Worldwide, it is the leading cause of disability in the under 40s. Behavioral problems, mood, cognition, particularly memory, attention, and executive function are commonly impaired by TBI. Spending to assist, TBI survivors with disabilities are estimated to be costly per year. Such impaired functional outcomes following TBI can be improved via various rehabilitative approaches. The objective of the present paper is to review the current rehabilitation treatment of traumatic brain injury in adults.

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“… 108 , 123 In addition, the expression of the group of proteins that comprise the inflammasome was also shown to be increased following TBI and reduced after subsequent HBOT. 121 These studies help provide support for an important influence of HBOT over the inflammatory response in acute TBI.…”

Section: Possible Mechanisms Of Actionmentioning

confidence: 87%

Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury

Eve¹,

Steele²,

Sanberg³

et al. 2016

NDT

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Traumatic brain injury (TBI) describes the presence of physical damage to the brain as a consequence of an insult and frequently possesses psychological and neurological symptoms depending on the severity of the injury. The recent increased military presence of US troops in Iraq and Afghanistan has coincided with greater use of improvised exploding devices, resulting in many returning soldiers suffering from some degree of TBI. A biphasic response is observed which is first directly injury-related, and second due to hypoxia, increased oxidative stress, and inflammation. A proportion of the returning soldiers also suffer from post-traumatic stress disorder (PTSD), and in some cases, this may be a consequence of TBI. Effective treatments are still being identified, and a possible therapeutic candidate is hyperbaric oxygen therapy (HBOT). Some clinical trials have been performed which suggest benefits with regard to survival and disease severity of TBI and/or PTSD, while several other studies do not see any improvement compared to a possibly poorly controlled sham. HBOT has been shown to reduce apoptosis, upregulate growth factors, promote antioxidant levels, and inhibit inflammatory cytokines in animal models, and hence, it is likely that HBOT could be advantageous in treating at least the secondary phase of TBI and PTSD. There is some evidence of a putative prophylactic or preconditioning benefit of HBOT exposure in animal models of brain injury, and the optimal time frame for treatment is yet to be determined. HBOT has potential side effects such as acute cerebral toxicity and more reactive oxygen species with long-term use, and therefore, optimizing exposure duration to maximize the reward and decrease the detrimental effects of HBOT is necessary. This review provides a summary of the current understanding of HBOT as well as suggests future directions including prophylactic use and chronic treatment.

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Effects of Hyperbaric Oxygen Therapy on Inflammasome Signaling after Traumatic Brain Injury

Cited by 24 publications

References 27 publications

Expert consensus on the diagnosis and treatment of heat stroke in China

Expert consensus on the diagnosis and treatment of heat stroke in China

Rehabilitation Treatment and Progress of Traumatic Brain Injury Dysfunction

Hyperbaric oxygen therapy as a potential treatment for post-traumatic stress disorder associated with traumatic brain injury

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