Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses

Toribio, Ramiro E.; Kohn, Catherine W.; Rourke, K.M.; Levine, Andrea L.; Rosol, Thomas J.

doi:10.2460/ajvr.68.5.543

Cited by 41 publications

(38 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood Ca 2+ decreased significantly in MSS compared to DS. In support of this finding, hypomagnesemia has been shown to be induced by hypercalcemia that occurs after administration of calcium gluconate solution IV . Higher plasma concentrations of Ca 2+ activate release of neurotransmitters and signal the nerve to fire, whereas decreased plasma Ca 2+ concentrations result in less calcium available for activation of the trigeminal nerve .…”

Section: Discussionmentioning

confidence: 89%

Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal‐mediated headshaking

Sheldon

Aleman

Costa

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

Background Trigeminal‐mediated headshaking results from low‐threshold firing of the trigeminal nerve resulting in apparent facial pain. Magnesium may have neuroprotective effects on nerve firing that potentially dampen signs of neuropathic pain. This hypothesis has not been investigated in horses with trigeminal‐mediated headshaking. Objective To investigate head‐shaking behavior in affected horses after IV magnesium sulfate infusion. Animals Six geldings with trigeminal‐mediated headshaking. Methods Prospective randomized crossover study. Horses were controlled for diet and infused IV with 5% dextrose solution (DS; control solution at 2 mL/kg body weight [BW]) and MgSO4 50% solution (MSS at 40 mg/kg BW). Head‐shaking behavior was recorded at times T0 (baseline, before infusion) and T15, T30, T60, and T120 minutes post‐infusion. Venous blood variables such as pH, HCO3−, standard base excess (SBE), Na+, Cl−, K+, Ca2+, Mg2+, total magnesium (tMg), glucose, and lactate were measured; strong ion difference (SID) and anion gap (AG) were calculated for each time point. Results Blood variables including pH, Na+, Cl−, K+, SID, AG, lactate, Ca2+, tMg, and Mg2+ had significant changes with MSS as compared to DS treatment. Glucose, SBE, and HCO3− did not have significant changes. A 29% reduction in head‐shaking rate occurred after MSS treatment but no change occurred after DS treatment. Conclusions and Clinical Importance Administration of MSS IV increased plasma total and ionized magnesium concentrations and significantly decreased head‐shaking behavior in horses with trigeminal‐mediated headshaking.

show abstract

Section: Discussionmentioning

confidence: 89%

Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal‐mediated headshaking

Sheldon

Aleman

Costa

et al. 2019

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Manure produced by these horses constitutes a considerable nutrient resource. Based on average nitrogen (N) (Graham-Thiers and Bowen 2011) and phosphorus (P) (Ögren 2013(Ögren , Fowler et al 2015 concentrations, and an average daily production of about 12-17 kg dung Dahlborn 1999, Fowler et al 2015) and 12 l urine (Toribio et al 2007), the horses in EU can be calculated to excrete over 300 million kg N and 48 million kg P annually. The N originates mainly from urine and P from dung (Schryver et al 1971, Särkijärvi andSaastamoinen 2014).…”

Section: Introductionmentioning

confidence: 99%

Recycling nutrients from horse manure: effects of bedding type and its compostability

Keskinen

Saastamoinen

Nikama

et al. 2017

AFSci

View full text Add to dashboard Cite

Manure constitutes a nutrient resource that should be efficiently recycled in agriculture. We assessed the nutrient cycling properties of three bedding materials (peat, wood shavings and pelleted straw) in horse manure by comparing their compostability, ability to retain nitrogen (N) and phosphorus (P) under rainfall and capacity to release N when mixed with soil. Manure with pelleted straw bedding had superior composting characteristics as it lost half of its dry mass, reached temperatures >60 °C and ended up having a carbon (C) to N (C:N) ratio of <15. In percolated water, 4-11% of total manure N and 5-23% of total manure P was leached during a 2 h 15 min event of artificial rainfall. Peat manure was most susceptible to P loss. In all fresh manures, C:N ratio exceeded 30, which led to net N immobilization in soil. Composting decreased the C:N leading to a slight positive or an insignificant fertilizer effect.

show abstract

“…After surgery, both calcium and potassium levels normalized. In horses, hypercalcemia has been associated with hypokalemia with increased urinary potassium excretion [32]. We could not ascertain the cause of this unexplained hypokalemia in our patient.…”

Section: Discussionmentioning

confidence: 81%

A case report: Giant cystic parathyroid adenoma presenting with parathyroid crisis after Vitamin D replacement

2012

View full text Add to dashboard Cite

BackgroundParathyroid adenoma with cystic degeneration is a rare cause of primary hyperparathyroidism. The clinical and biochemical presentation may mimic parathyroid carcinoma.Case presentationWe report the case of a 55 year old lady, who had longstanding history of depression and acid peptic disease. Serum calcium eight months prior to presentation was slightly high, but she was never worked up. She was found to be Vitamin D deficient while being investigated for generalized body aches. A month after she was replaced with Vitamin D, she presented to us with parathyroid crisis. Her corrected serum calcium was 23.0 mg/dL. She had severe gastrointestinal symptoms and acute kidney injury. She had unexplained consistent hypokalemia until surgery. Neck ultrasound and CT scan revealed giant parathyroid cyst extending into the mediastinum. After initial medical management for parathyroid crisis, parathyroid cystic adenoma was surgically excised. Her serum calcium, intact parathyroid hormone, creatinine and potassium levels normalized after surgery.ConclusionThis case of parathyroid crisis, with very high serum calcium and parathyroid hormone levels, is a rare presentation of parathyroid adenoma with cystic degeneration. This case also highlights that Vitamin D replacement may unmask subclinical hyperparathyroidism. Consistent hypokalemia until surgery merits research into its association with hypercalcemia.

show abstract

Effects of hypercalcemia on serum concentrations of magnesium, potassium, and phosphate and urinary excretion of electrolytes in horses

Cited by 41 publications

References 38 publications

Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal‐mediated headshaking

Intravenous infusion of magnesium sulfate and its effect on horses with trigeminal‐mediated headshaking

Recycling nutrients from horse manure: effects of bedding type and its compostability

A case report: Giant cystic parathyroid adenoma presenting with parathyroid crisis after Vitamin D replacement

Contact Info

Product

Resources

About