Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

Brito, Marcus Vinicius Henriques; Yasojima, Edson Yuzur; Percário, Sandro; Júnior, Rubens Fernando Gonçalves Ribeiro; Cavalcante, Lainy Carollyne da Costa; Monteiro, Andrew Moraes; Couteiro, Rodrigo Paracampo; Rodrigues, Ivone Aline da Silva; Santos, Hellen Aparecida Geyer dos

doi:10.1590/s0102-865020170030000005

Cited by 9 publications

(4 citation statements)

References 25 publications

(24 reference statements)

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“…Interestingly, hypertonic saline, which has protective effects on ischemia reperfusion, as well as antioxidant and anti-apoptotic effects [29,30], protect kidneys from injury. Furthermore, Kreimier et al showed that hypertonic saline solution effectively improved renal microcirculation [31] and protected shock kidney by infusion of small doses [32]. This study basically supports this theory.…”

Section: Discussionsupporting

confidence: 79%

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Kang²,

et al. 2019

Med Sci Monit

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Departmental sources Background: Our previous study found a novel fluid combination with better resuscitation effects under hypotensive condition at the early stage of uncontrolled hemorrhagic shock (UHS). However, the optimal recovery concentration of hypertonic saline in this fluid combination remains unknown. This experiment aimed to explore the optimal concentration. Material/Methods: New Zealand white rabbits (n=40) were randomly divided into 5 groups, including a sham-operated group (SO), a shock non-treated group (SNT), a normal saline group (NS), and hypertonic saline groups (4.5% and 7.5%). We established an UHS model and administered various fluid combinations (dose-related sodium chloride solution+crystal-colloidal solution) to the groups followed by monitoring indexes of hemodynamic and renal function, measuring infusion volume and blood loss, and analyzing pathological morphology by hematoxylin and eosin staining. Results: The hypertonic saline groups showed more stable hemodynamic indexes, reduced blood loss, fewer required infusions, and milder decreases in renal function than those of control groups (SNT and NS groups), and exhibited fewer pathological changes in the heart, lung, kidney, and liver. All indexes in the 4.5% and 7.5% groups were better than those of the NS group, and the hemodynamic indexes in the 7.5% group were more stable than those of the 4.5% group (P<0.05), with reduced blood loss and infusion volume and a milder decrease in renal function. Conclusions: The novel fluid combination with 7.5% hypertonic saline group had a better recovery effect at the early stage of UHS before hemostasis compared to that of the 4.5% hypertonic saline group. This result may provide guidance for clinical fluid resuscitation.

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Section: Discussionsupporting

confidence: 79%

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Kang²,

et al. 2019

Med Sci Monit

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“…On the other hand, in the samples of intestinal tissue, there was a difference between sham and perconditioning groups when compared to the IR, suggesting that the ischemic-reperfusion process to which the animals in the IR group were submitted resulted in an increase in the levels of free radicals, as well as, consequently, in the involvement of oxidative stress 23 .…”

Section: Discussionmentioning

confidence: 95%

Ischemic perconditioning on mesenteric ischemia/reperfusion injury in rats

et al. 2021

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“…RIPerC, as one of the effective and newest protective techniques, alleviates renal (Brito et al 2017;Ogawa et al 2001;Sedaghat et al 2016) and liver IRI (Costa et al 2014) Under stress conditions such as renal I/R, after prolonged ischemia, blood flow reperfusion leads to production of reactive oxygen species (ROS) from damaged mitochondria (Granger and Kvietys 2015). An unbalance between ROS production and defensive capacity of the cells leads to oxidative stress (Birben et al 2012;Tarantino et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Remote ischemic per-conditioning protects against renal ischemia–reperfusion injury via suppressing gene expression of TLR4 and TNF-α in rat model

Gholampour

Roozbeh

Janfeshan

et al. 2019

Can. J. Physiol. Pharmacol.

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The pathogenesis of renal ischemia–reperfusion injury (IRI) involves both inflammatory processes and oxidative stress in the kidney. This study determined whether remote ischemic per-conditioning (RIPerC) is mediated by toll-like receptor 4 (TLR4) signaling pathway in rats. Renal IR injury was induced by occluding renal arteries for 45 min followed by 24 h of reperfusion. RIPerC included 4 cycles of 2 min of ischemia of the left femoral artery followed by 3 min of reperfusion performed at the start of renal ischemia. Rats were divided into sham, IR, and RIPerC groups. At the end of the reperfusion period, urine, blood and tissue samples were gathered. IR created kidney dysfunction, as ascertained by a significant decrease in creatinine clearance and a significant increase in sodium fractional excretion. These changes occurred in concert with a decrease in the activities of glutathione peroxidase, catalase, and superoxide dismutase with an increment in malondialdehyde levels, mRNA expression levels of TLR4 and tumor necrosis factor α (TNF-α), and histological damage in renal tissues. RIPerC treatment diminished all these changes. This study demonstrates that RIPerC has protective effects on the kidney after renal IR, which might be related to the inhibition of the TLR4 signaling pathway and augmentation of antioxidant systems.

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Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

Abstract: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion.

Cited by 9 publications

References 25 publications

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock

Ischemic perconditioning on mesenteric ischemia/reperfusion injury in rats

Remote ischemic per-conditioning protects against renal ischemia–reperfusion injury via suppressing gene expression of TLR4 and TNF-α in rat model

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