Effects of indigowoad root (Radix Isatidis) on the immune responses and HSP70 gene expression of medicinal leeches (Poecilobdella manillensis) under Proteus mirabilis infection

Liu, Fei; Cheng, Biao; Q, Guo; Shi, Hong-Zhuan; Gou, Ling; Lu, Yinghua; Wang, Jia; Shen, Wenbiao; Yan, Shi-Meng; Wu, Man-Jun

doi:10.1016/j.aquaculture.2015.12.012

Cited by 6 publications

(3 citation statements)

References 68 publications

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“…Our results showed that the expression of HSP70 and IMD genes in the hepatopancreas were significantly increased in prawn fed with diets containing garlic extract compared to the control group. HSP70 act as a molecular stress protein, which can contribute to the maintenance of cellular homoeostasis (Liu et al, 2016) and endogenous peroxidase activity for catalyzing the conversion of ROS (Duan et al, 2018). Consistent with our results, previous literature showed the up‐regulation of related‐immune genes following feeding Nile tilapia ( O. niloticus ) with diet containing Spirulina platensis + garlic (Mustafa Abu‐Elala, 2016).…”

Section: Discussionmentioning

confidence: 99%

Effect of garlic (Allium sativum) extract on growth, enzymological and biochemical responses and immune‐related gene expressions in giant freshwater prawn (Macrobrachium rosenbergii)

Jahanbakhshi

Pourmozaffar

Adeshina

et al. 2022

Animal Physiology Nutrition

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In the current study, growth performance, biochemical constituents of muscle, activities of enzymes in the haemolymph, and expressions of immune-related genes were evaluated in the giant freshwater prawns Macrobrachium rosenbergii fed diets supplemented with aqueous garlic (Allium sativum) extract at 0, 5, 10 and 20 g/kg (w/w) for 60 days. At the end of the feeding trial, weight gain and specific growth rate were significantly improved in garlic-fed prawn groups compared with the control (p < 0.05). Moreover, feed conversion ratio was significantly lower in the garlic-fed groups than in the control (p < 0.05). Activities of catalase, superoxide dismutase and glutathione peroxidase in the hepatopancreas, activities of alanine aminotransferase, aspartate aminotransferase and levels of albumin and total protein in the hemolymph were significantly increased in the garlic treatments (p < 0.05). Furthermore, garlic supplemented diets improved muscle biochemical profiles, particularly contents of crude protein and total ash and upregulations of immune deficiency and heat shock proteins (HSP70) gene expression (p < 0.05). Therefore, garlic has positive effects on growth performance and physio-biochemical responses of M. rosenbergii, and thus, it can be used as an additive for stress resistance and as a growth promoter in sustainable aquaculture.

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Section: Discussionmentioning

confidence: 99%

Effect of garlic (Allium sativum) extract on growth, enzymological and biochemical responses and immune‐related gene expressions in giant freshwater prawn (Macrobrachium rosenbergii)

Jahanbakhshi

Pourmozaffar

Adeshina

et al. 2022

Animal Physiology Nutrition

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“…3,4 It contains various constituents with different structural features, such as alkaloids, lignans, indirubin, clemastanin B, ceramides, flavonoids, epigoitrin, and polysaccharides, etc. [5][6][7] Meanwhile, the extracts of R. isatidis display extensive biological activity, for instance, antiviral, [8][9][10][11] anti-inflammatory, 12 antipyretic, 13 neuroprotective, 14 antibiotic, 15 and antidiabetic activity. 16 However, it is difficult to fully elucidate which chemical component causes the corresponding pharmacological efficacy in the use of traditional Chinese medicine.…”

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confidence: 99%

Multigram Scale Synthesis and Anti-Influenza Activity of 3-Indoleacetonitrile Glucosides

Dong

Yan

et al. 2020

Natural Product Communications

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Indole-3-acetonitrile-6- O-β-d-glucopyranoside 1 is a simple alkaloid with anti-influenza A virus activity extracted from Radix isatidis. Herein, a concise and practical total synthetic route of 1 was presented, starting from 6-benzyloxyindole on a multigram scale. The pivotal reaction sequence involved the Mannich reaction, the fluoride ion-induced elimination-addition reaction, and phase-transfer-catalyzed glycosylation reaction as key steps. In addition, compounds 1 and two modified derivatives 8 and 16 were tested for anti-influenza efficacy and cytotoxicity in vitro performed on Madin-Darby canine kidney cells. The results revealed that the compounds exerted antiviral activity against the influenza A virus to a certain extent and displayed no cytotoxicity. These findings could contribute to the development of traditional Chinese medicine R. isatidis for treating the influenza virus.

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“…At present, the main research on medicinal leeches has focused on their biological characteristics (Meng et al, 2013;Liu et al, 2014;Shi et al, 2006;Ceylan et al,. 2015;Cheng et al,2015;Liu et al,2016a) and genetic structures (Liu et al, 2013a;Liu et al, 2013b;Liu et al, 2011;Liu et al, 2016b). Meanwhile, the main research of P. manillensis has focused on pharmacology and drug efficacy (Feng et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Cheng¹,

Gou²,

Q³

et al. 2016

Turk. J. Fish. Aquat. Sci.

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The effects of different water temperatures on the growth, feed intake and antithrombin activity of P. manillensis were studied in order to identify the optimum water temperature for growth. After P. manillensis were cultured at the water temperatures of 18, 22, 26, 30, 34, 38 °C and room temperature (RT), final body weight (FBW), weight gain rate (RWG), specific growth rate (SGR), feed conversion rate (FC), average feed intake per time (AFI), average feed intake rate per time (AFIR), survival rate (SR) and antithrombin activity (AT) were measured for 64 days. The result showed that FBW, RWG, SGR, AFI, and SR of P. manillensis presented different growth indices that were higher than other experimental treatments at 26-30 °C (P<0.05), while FC was lower than others. The optimal water temperature range for P. manillensis was 26-30 °C, and the results indicate that the maximum AT (295.52 U) occurs at 34 °C (P<0.05). Keywords:The optimal water temperature, specific growth rate, feed conversion rate.

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Effects of indigowoad root (Radix Isatidis) on the immune responses and HSP70 gene expression of medicinal leeches (Poecilobdella manillensis) under Proteus mirabilis infection

Cited by 6 publications

References 68 publications

Effect of garlic (Allium sativum) extract on growth, enzymological and biochemical responses and immune‐related gene expressions in giant freshwater prawn (Macrobrachium rosenbergii)

Effect of garlic (Allium sativum) extract on growth, enzymological and biochemical responses and immune‐related gene expressions in giant freshwater prawn (Macrobrachium rosenbergii)

Multigram Scale Synthesis and Anti-Influenza Activity of 3-Indoleacetonitrile Glucosides

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