Effects of interleukins, colony-stimulating factor and tumour necrosis factor on human hair follicle growth <i>in vitro:</i>
 a possible role for interleukin-1 and tumour necrosis factor-α in alopecia areata

Philpott, Michael P.; Sanders, Deborah A.; Bowen, Joanne M.; Kealey, Terence

doi:10.1046/j.1365-2133.1996.d01-1099.x

Cited by 165 publications

(149 citation statements)

References 25 publications

Supporting

Mentioning

141

Contrasting

Unclassified

Order By: Relevance

“…It is known that the proinflammatory mediators IL-1 and TNF-a are potent MIF polymorphism in extensive alopecia areata T Shimizu et al inhibitors of hair follicle cell proliferation, with a concomitant inhibition of hair growth. 17 MIF is upregulated by TNF-a, and MIF in turn augments the secretion TNF-a. 4,23 Therefore, these inflammatory cytokines may be implicated in the induction or continuation of damage to hair follicles, and MIF may play an important part in the pathophysiology of inflammatory hair loss as in AA.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

et al. 2005

View full text Add to dashboard Cite

We have demonstrated that serum macrophage migration inhibitory factor (MIF) was significantly elevated in patients with extensive alopecia areata (AA). Recently, functional polymorphisms have been identified in the MIF promoter region. To address the functional and prognostic relevance of the À173G/C and À794[CATT] 5-8 repeat polymorphisms in MIF genes in patients with extensive AA, 113 patients with extensive AA and 194 healthy controls were genotyped. We found that MIFÀ173*C was a risk factor for early onset (o20 years) of extensive AA (odds ratio for GC heterozygotes with À173G/C was 4.88 (95% CI, 2.04-11.8), P ¼ 0.00038; odds ratio for CC homozygotes with À173G/C was 10.42 (95% CI, 2.56-43.5), P ¼ 0.0011). We found no statistically significant differences in the genotype frequencies of the À794[CATT] 5-8 repeat polymorphism and extensive AA. These results suggest that polymorphisms within the MIFÀ173*C allele confer an increased risk of susceptibility to the extensive forms of AA, especially with an early onset of disease. MIF is therefore suggested to be closely implicated in the pathogenesis of the more extensive forms of AA.

show abstract

Section: Discussionmentioning

confidence: 98%

“…16 TNF-a also inhibits hair follicle growth in vitro. 17 The IL-1 and TNF-a gene polymorphisms have been previously investigated. Galbraith et al 18 found evidence of increased susceptibility to AA with certain IL-1/immunogloblin k lightchain genotypes.…”

Section: Discussionmentioning

confidence: 99%

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

et al. 2005

View full text Add to dashboard Cite

show abstract

“…The pathogenesis is not fully elucidated but studies suggest proinflammatory cytokines such as IL-1α, IL-1β, and TNF-α play a major role in disease progression [14]. As such, one would expect TNF-α inhibitors to be effective treatment options for this condition.…”

Section: Clinical Subtypes Of Alopecia Seen During Treatment With Tnfmentioning

confidence: 99%

Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors

Tosti¹

2014

J Clin Investig Dermatol

View full text Add to dashboard Cite

Background: Alopecia is a possible adverse reaction to Tumor Necrosis Factor alpha (TNF-α) inhibitors. This side effect has become more recognized in recent years through FDA postmarketing surveillance and it description in case reports/case series. Objective:We review the literature and summarize the pathogenesis, clinical presentation, prognosis, and management strategies for TNF-α inhibitor induced alopecia. Methods:We performed a Medline search from January 1998 until August 2013 to identify all cases of alopecia during anti-TNF-α therapy described in the literature. We also reviewed FDA postmarketing data and clinical trials.Results: There were 62 cases of hair loss occurring during therapy with TNF-α inhibitors that we identified during our literature search. The causes of hair loss included alopecia areata, psoriatic alopecia, lichen planopilaris, drug-induced lupus erythematosus, androgenetic alopecia, and telogen effluvium. Alopecia was also a mentioned side effect in three clinical trials and in FDA postmarketing surveillance.Limitations: There are few controlled trials directly studying TNF-α inhibitor induced alopecia and most of our understanding of this clinical condition comes from anecdotal experience.Conclusions: TNF-α inhibitors can cause different types of hair loss including severe alopecia areata and scarring alopecia.

show abstract

“…Various factors may play role in the pathogenesis of AA like cytokines including interleukin I (IL-I) alpha, IL-I beta and tumor necrosis alpha (TNF-α) 119 which is synthesized and released into the extracellular milieu by immune and non immune cells during inflammatory processes leading to stimulation of intracellular production of mitochondrial ROS 120 initiating an increase in the cellular antioxidant defense mechanism, i.e. an increase in SOD and GSH-Px activity 121 .…”

Section: Cholestatic Liver Injurymentioning

confidence: 99%

Untitled

2011

IJPSR

View full text Add to dashboard Cite

Lipid peroxidation (LPO) in cellular membranes is associated with changes in physicochemical properties and impairment of protein functions located in membrane environment. Recent studies shows involvement of LPO in biological signaling and various diseases. Lipids are oxidized by three distinct mechanisms: enzymatic oxidation; non-enzymatic, free radical-mediated oxidation and non-enzymatic, non radical oxidation. Lipids containing polyunsaturated fatty acids are susceptible to free radical-initiated oxidation and can participate in chain reactions that increase damage to biomolecules. Polyunsaturated fatty acids (PUFAs) and their metabolites have variety of physiological roles including: energy provision, membrane structure, cell signaling and regulation of gene expression. The present manuscript reviews concept of LPO with emphasis on implication in various diseases.

show abstract

Effects of interleukins, colony-stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin-1 and tumour necrosis factor-α in alopecia areata

Cited by 165 publications

References 25 publications

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

Hair Loss Induced by Tumor Necrosis Factor Alpha Inhibitors

Untitled

Contact Info

Product

Resources

About