Effects of Ionic Liquid as Additive and the pH of the Mobile Phase on the Retention Factors of Amino Benzoic Acids in RP-HPLC

Zheng, Jinzhu; Polyakova, Yulia; Row, Kyung Ho

doi:10.1093/chromsci/45.5.256

Cited by 18 publications

(4 citation statements)

References 24 publications

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“…Zheng et al [26] reported that the aqueous mobile phase showed acidity when 0.03 mol/L of [EMIM][MS] was used as the additive. In Figure 8, the target compounds can be obtained via base-line separation by using a mobile phase with 0.01 mol/L of [EMIM][MS].…”

Section: Resultsmentioning

confidence: 99%

Effect of Mobile Phase Additives on the Resolution of Four Bioactive Compounds by RP-HPLC

Tian

Row

2010

IJMS

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The use of mobile phase additives enhances the separation and resolution of the bioactive compounds on the C18 column. Chlorogenic acid, caffeic acid, rutin, and scoparone from Herba Artemisiae Scopariae were investigated as the target compounds. Acetic acid, triethylamine, inorganic salts, and several ionic liquids were added as mobile phase additives into methanol/water (40:60, v/v). The result revealed that a mobile phase with 0.01 mol/L of ionic liquid [BMIM][BF4] enabled the optimum separation of the four target compounds.

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Section: Resultsmentioning

confidence: 99%

Effect of Mobile Phase Additives on the Resolution of Four Bioactive Compounds by RP-HPLC

Tian

Row

2010

IJMS

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“…Considering that it was previously reported69 that the addition of [C 2 C 1 Im][C 1 SO 4 ] to the mobile phase increases its acidic character, the authors47 also evaluated its effect on the separation of phenolic compounds. In fact, better results were attained with [C 2 C 1 Im][C 1 SO 4 ] compared to the addition of conventional additives, namely acetic acid and NaH 2 PO 4 .…”

Section: Improvement Of Chromatographic and Electrophoretic Methods Umentioning

confidence: 99%

Ionic liquids in chromatographic and electrophoretic techniques: toward additional improvements in the separation of natural compounds

et al. 2016

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Due to their unique properties, in recent years, ionic liquids (ILs) have been largely investigated in the field of analytical chemistry. Particularly during the last sixteen years, they have been successfully applied in the chromatographic and electrophoretic analysis of value-added compounds extracted from biomass. Considering the growing interest in the use of ILs in this field, this critical review provides a comprehensive overview on the improvements achieved using ILs as constituents of mobile or stationary phases in analytical techniques, namely in capillary electrophoresis and its different modes, in high performance liquid chromatography, and in gas chromatography, for the separation and analysis of natural compounds. The impact of the IL chemical structure and the influence of secondary parameters, such as the IL concentration, temperature, pH, voltage and analysis time (when applied), are also critically addressed regarding the achieved separation improvements. Major conclusions on the role of ILs in the separation mechanisms and the performance of these techniques in terms of efficiency, resolution and selectivity are provided. Based on a critical analysis of all published results, some target-oriented ILs are suggested. Finally, current drawbacks and future challenges in the field are highlighted. In particular, the design and use of more benign and effective ILs as well as the development of integrated (and thus more sustainable) extraction-separation processes using IL aqueous solutions are suggested within a green chemistry perspective.

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“…There are many publications [60–72] reported the analysis of amino acids or nucleic compounds using ILs as additives. Mun et al .…”

Section: Separation Of Biological Samplesmentioning

confidence: 99%

Application of Ionic Liquids in High Performance Reversed-Phase Chromatography

Wang

Tian

et al. 2009

IJMS

104

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Ionic liquids, considered “green” chemicals, are widely used in many areas of analytical chemistry due to their unique properties. Recently, ionic liquids have been used as a kind of novel additive in separation and combined with silica to synthesize new stationary phase as separation media. This review will focus on the properties and mechanisms of ionic liquids and their potential applications as mobile phase modifier and surface-bonded stationary phase in reversed-phase high performance liquid chromatography (RP-HPLC). Ionic liquids demonstrate advantages and potential in chromatographic field.

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Effects of Ionic Liquid as Additive and the pH of the Mobile Phase on the Retention Factors of Amino Benzoic Acids in RP-HPLC

Cited by 18 publications

References 24 publications

Effect of Mobile Phase Additives on the Resolution of Four Bioactive Compounds by RP-HPLC

Effect of Mobile Phase Additives on the Resolution of Four Bioactive Compounds by RP-HPLC

Ionic liquids in chromatographic and electrophoretic techniques: toward additional improvements in the separation of natural compounds

Application of Ionic Liquids in High Performance Reversed-Phase Chromatography

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