Effects of ionic liquid on micellar aggregate formed by pluronic (F-127) and non-ionic surfactant (TX-100) in aqueous solution

Azum, Naved; Alfaifi, Sulaiman Y. M.; Rub, Malik Abdul; Asiri, Abdullah M.

doi:10.1016/j.molliq.2023.121617

Cited by 7 publications

(1 citation statement)

References 66 publications

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“…These synergistic effects include increased wetting, detergency, solubilization, and surface activity. In equilibrium with the surfactant monomers, mixed micellar aggregates are made up of two or more distinct surfactants (Azum et al, 2019; Azum et al, 2023; Kumar et al, 2022; Kumar, Raj, et al, 2021; Kumar, Singh, et al, 2021; Mahajan & Mahajan, 2012; Srivastava et al, 2015; Srivastava, Liu, et al, 2018; Srivastava, Qiao, & Ismail, 2018; Srivastava, Thapa, et al, 2019; Srivastava, Uchiyama, et al, 2019; Uchiyama et al, 2018; Vashishat et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Binding and occupancy properties of gabapentin in mixed surfactant systems

Kumar,

Khushi,

Singh

et al. 2023

J Surfact & Detergents

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This research highlights the efficacy of mixed micellar systems as an innovative chemical formulation for improving the binding properties of active pharmaceutical drugs. The formulations based on the mole fraction were utilized for preparing mixed micelles with anionic sodium dioctyl sulfosuccinate (AOT) and sodium dodecyl sulphate (SDS). DLS measurements demonstrated the formation of small micelles and mixed micelles in SDS‐AOT combinations. A UV absorbance investigation demonstrated the effectiveness of the SDS‐AOT mixed micelles for determining the binding constant (Kb) and mean ion occupancy (i0) of the anticonvulsant gabapentin (GBP) drug. Kb values increased, but the occupancy (i) of GBP per micelle decreased by decreasing the mole fraction (α) of SDS from αSDS 0.9 to 0.1, predicting a shift in occupancy of drugs from the Palisade to the Stern layer. To get a better comprehension of micellization behavior and preferential interaction of the drugs under study, molecular docking studies were performed. According to the docking studies, the GBP displayed significant binding in the presence of SDS‐AOT when compared to pure SDS and AOT molecules. Ultimately, in pharmaceutical applications, mixed micelle played an important role in enhancing the binding and encapsulation efficiency of drugs.

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