Effects of L-citrulline diet on stress-induced cold hypersensitivity in mice

Kobayashi, Yoshinori; Narita, Kouji; Chiba, Kaori; Takemoto, Hiroaki; Murakami, Masahiko

doi:10.4103/0974-8490.138269

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…In rats, consumption of watermelon extracts with high citrulline resulted in improved lipid profiles, lower inflammation, and higher antioxidant capacity (Hong et al, 2015). In mice, hypothermia recovery and vascular endothelium function were improved in subjects administered a 1% dose of citrulline (Kobayashi et al, 2014). Free arginine, administered through supplements, can result in side effects such as nausea and gastrointestinal discomfort, prompting physicians to seek alternative forms of arginine (Collins et al, 2007;Hong et al, 2015).…”

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confidence: 99%

Heritability and Genetic Variance Components Associated with Citrulline, Arginine, and Lycopene Content in Diverse Watermelon Cultigens

Wehner¹,

Naegele²,

Perkins-Veazie³

2017

horts

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Citrulline, arginine, and lycopene are naturally occurring compounds found in watermelon, Citrullus lanatus (Thumb) Matsum & Nakai, with beneficial effects on plant growth and human health. This study evaluated seven commercial cultivars and one breeding line for citrulline, arginine, and lycopene content in mature fruit grown at two locations in North Carolina. Correlations among these compounds and fruit quality traits (percent soluble solids and flesh pH) were evaluated. Watermelon cultigens evaluated were chosen for their fruit trait diversity. ‘Yellow Doll’ and NC-517 possessed the highest citrulline and combined concentration of citrulline and arginine of all cultigens evaluated. Lycopene content was highest in ‘Dixielee’, followed by ‘Sugar Baby’, and ‘Allsweet’, each of which have different shades of red flesh color. Location and its interaction with genotype had no significant effect on arginine or lycopene concentration. Broad-sense heritability was estimated for each trait. Arginine content (89%) and lycopene content (99%) had very high heritability. Citrulline content (41%), percent soluble solids (46%), and flesh pH (61%) had moderate heritability. Lycopene was positively correlated with flesh pH (r = 0.517) and negatively correlated with percent soluble solids (r = −0.344). Arginine content had a weak negative correlation with flesh pH (r = −0.343) and was not correlated with percent soluble solids.

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confidence: 99%

Heritability and Genetic Variance Components Associated with Citrulline, Arginine, and Lycopene Content in Diverse Watermelon Cultigens

Wehner¹,

Naegele²,

Perkins-Veazie³

2017

horts

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“…However, we did not measure FMD in those previous studies. In mice, CIT supplementation attenuated cold hypersensitivity by improving endothelial function [ 52 ]. In the current study, the attenuation of aortic MAP reactivity to CPT was related to improvements in FMD.…”

Section: Discussionmentioning

confidence: 99%

Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women

et al. 2023

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Postmenopausal women (PMW) may experience endothelial dysfunction associated with arginine (ARG) deficiency relative to asymmetric dimethylarginine (ADMA) caused by oxidative stress. Endothelial dysfunction contributes to increased blood pressure (BP) responsiveness to sympathoexcitation induced by the cold pressor test (CPT). We investigated the effects of citrulline alone (CIT) and combined with the antioxidant glutathione (CIT+GSH) on vascular function. Forty-four healthy PMW were randomized to CIT (6 g), CIT+GSH (2 g + 200 mg: Setria®) or placebo (PL) for 4 weeks. Brachial artery flow-mediated dilation (FMD), aortic stiffness (pulse wave velocity, PWV), brachial and aortic BP reactivity to CPT, and serum fasting blood glucose (FBG), ARG, and ARG/ADMA ratio were measured. Baseline FBG was higher in CIT+GSH vs. PL. FMD increased after CIT+GSH vs. PL (p < 0.05). CIT and CIT+GSH increased ARG/ADMA (p < 0.05), but did not affect aortic PWV. CIT+GSH attenuated the brachial and aortic systolic BP and mean arterial pressure (MAP) responses to CPT vs. PL and CIT (p < 0.05). The improvements in FMD were related to baseline FMD (r = −0.39, p < 0.05) and aortic MAP response to CPT (r = −0.33, p < 0.05). This study showed that CIT+GSH improved FMD and attenuated systolic BP and MAP reactivity in PMW. Although CIT increased ARG/ADMA, it did not improve FMD in healthy PMW.

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“…Elevated plasma citrulline levels are presumed beneficial for promoting wound healing. Furthermore, citrulline produces nitric oxide (NO) during the metabolic process, which dilates blood vessels and promotes blood circulation [ 33 , 72 , 84 ]. An improvement in blood flow by NO production is considered to contribute to an increase in body temperature and the heat retention effect.…”

Section: Discussionmentioning

confidence: 99%

Hot spring bathing accelerates wound healing and enhances heat retention effect in guinea pigs

Inaka

Kimura

2022

The Journal of Veterinary Medical Science

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This study aimed to demonstrate the effects of hot springs on wound healing and heat retention by performing comparative experiments with tap water. The hot spring water used in this study was from an alkaline hot spring that was rich in sodium and chloride ions and exhibited high reducibility. Guinea pigs were divided into a hot spring bathing group and a tap water bathing group, and a bathing test was conducted for eight consecutive days. A comparison of the plasma amino acid composition between the two groups after the bathing test revealed differences in the concentrations of several amino acids associated with wound healing. Image analysis demonstrated that wounds made on the abdominal skin of guinea pigs were significantly contracted by hot spring bathing compared to that by tap water bathing, and histopathological findings showed that wound healing was accelerated. In the thermography test, changes in body surface temperature after bathing were investigated in both groups. The heat retention effect was not observed in the tap water bathing group after bathing, whereas it was enhanced in the hot spring bathing group until 30 min after bathing. In conclusion, this study demonstrated that hot spring bathing accelerates wound healing and has a more significant heat retention effect than tap water bathing.

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Effects of L-citrulline diet on stress-induced cold hypersensitivity in mice

Cited by 7 publications

References 20 publications

Heritability and Genetic Variance Components Associated with Citrulline, Arginine, and Lycopene Content in Diverse Watermelon Cultigens

Heritability and Genetic Variance Components Associated with Citrulline, Arginine, and Lycopene Content in Diverse Watermelon Cultigens

Combined Citrulline and Glutathione Supplementation Improves Endothelial Function and Blood Pressure Reactivity in Postmenopausal Women

Hot spring bathing accelerates wound healing and enhances heat retention effect in guinea pigs

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