Effects of Lactobacillus coryniformis K8 CECT5711 on the immune response to influenza vaccination and the assessment of common respiratory symptoms in elderly subjects: a randomized controlled trial

Fonolla, J.; Gracián, Carlos; Maldonado-Lobón, Jose A.; Romero, Claudia; Bédmar, Alicia; Carrillo, Juan Carlos Flores; Martín-Castro, Carmen; Cabrera, Antonio L.; García-Curiel, Jose M.; Rodríguez, Carlos Sánchéz; Sanbonmatsu, Sara; Pérez-Ruiz, Mercedes; Navarro, José María; Olivares, Mónica

doi:10.1007/s00394-017-1573-1

Cited by 37 publications

(39 citation statements)

References 26 publications

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“… 2013 ; Fonollá et al. 2019 ). We also observed a shorter duration of medication, probably due to less severe URTI symptoms, though the duration of sick leave did not significantly change between the two groups.…”

Section: Discussionmentioning

confidence: 99%

Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial

Zhang

Miao²,

Su³

et al. 2021

Pharmaceutical Biology

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Context Upper respiratory tract infection (URTI) is the most common illness in humans. Fermented milk containing probiotics can mitigate URTI symptoms. Objective This study tests the effect of fermented milk (Qingrun), a yogurt supplemented with Bifidobacterium animalis subsp. lactis Bl-04, on adults with URTIs who live in a haze-covered area in a randomized clinical trial. Materials and methods A total of 136 subjects were enrolled in the study at the baseline and randomized to consume either control yogurt or Qingrun yogurt (250 g) once daily for 12 weeks. The duration and severity of URTI were evaluated by the Wisconsin Upper Respiratory Symptom Survey–24. Blood and faecal samples were collected at the baseline and post-intervention, to determine the changes of immune biomarkers. Results Qingrun yogurt significantly reduced the incidence of the common cold (OR, 0.38; 95% CI, 0.17–0.81; p = 0.013) and influenza-like illness (OR, 0.32; 95% CI, 0.11–0.97; p = 0.045). Compared to the control yogurt, Qingrun yogurt significantly reduced the duration (1.23 ± 2.73 vs. 4.78 ± 5.09 d) and severity score (3.58 ± 7.12 vs. 11.37 ± 11.73) of URTI. In addition, the post-intervention levels of interferon-γ (139.49 ± 59.49 vs. 113.45 ± 65.12 pg/mL) and secretory immunoglobulin A (529.19 ± 91.70 vs. 388.88 ± 53.83 mg/dL) significantly increased in the Qingrun group, compared with those in the control group. Conclusions Qingrun yogurt showed a protective effect against URTI in adults, suggesting that the use of yogurt with probiotics could be a promising dietary supplement for mitigating URTI.

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Section: Discussionmentioning

confidence: 99%

Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial

Zhang

Miao²,

Su³

et al. 2021

Pharmaceutical Biology

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“…It has been reported that probiotic with regulating the balance of intestinal microecology exerts prophylactic and alleviating effects on diseases, such as allergic asthma [ 20 , 21 ], atopic dermatitis [ 22 , 23 ], and influenza infection [ 24 , 25 ], but the correlation between clinical characters of influenza infection and gut microbial alteration needs to be explained. Based on the gut–lung axis theory, the bi-directional cross-talk between lung and gut intricately influences the homeostasis of both [ 26 ], and therefore, the deeper understanding of gut microbial alteration on alleviating respiratory disorders contributes to therapeutic applications using probiotic strains.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice

Liu

Fang

Liu

et al. 2021

Foods

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Influenza A virus induces severe respiratory tract infection and results in a serious global health problem. Influenza infection disturbs the cross-talk connection between lung and gut. Probiotic treatment can inhibit influenza virus infection; however, the mechanism remains to be explored. The mice received Lactobacillus mucosae 1025, Bifidobacterium breve CCFM1026, and their mixture MIX for 19 days. Effects of probiotics on clinical symptoms, immune responses, and gut microbial alteration were evaluated. L. mucosae 1025 and MIX significantly reduced the loss of body weight, pathological symptoms, and viral loading. B. breve CCFM1026 significantly reduced the proportion of neutrophils and increased lymphocytes, the expressions of TLR7, MyD88, TRAF6, and TNF-α to restore the immune disorders. MIX increased the antiviral protein MxA expression, the relative abundances of Lactobacillus, Mucispirillum, Adlercreutzia, Bifidobacterium, and further regulated SCFA metabolism resulting in an enhancement of butyrate. The correlation analysis revealed that the butyrate was positively related to MxA expression (p < 0.001) but was negatively related to viral loading (p < 0.05). The results implied the possible antiviral mechanisms that MIX decreased viral loading and increased the antiviral protein MxA expression, which was closely associated with the increased butyrate production resulting from gut microbial alteration.

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“…infantis 10 9 and 8 g Gluco-Oligosaccharide for 8 weeks. Vaccine challenge at week 4 In vitro flu-vaccine antigen recall challenge No significant result Fonolla et al [ 136 ] R DB PC n = 98 Nursing home residents 83 ± 6 3.10 9 Lactobacillus coryniformis K8 CECT5711 daily capsule for 2 weeks prior vaccination Trivalent influenza vaccine response and incidence or severity of influenza-like illness (ILI) Higher seroconversion rate and reduced medication intake and incidence of ILI over a follow-up of 5 months Fukushima et al [ 137 ] R DB PC n = 24 Hospitalized elderly patients 84 ± 6 Enteral supplement feeding with fermented milk (89 kcal/d) containing 10 9 probiotic Lactobacillus johnsonii La1 for 12 weeks Incidence of infection Reduction in the number of days with infection. Improvement in the nutritional status.…”

Section: General Hallmarks Of Immune Agingmentioning

confidence: 99%

The aging gut microbiome and its impact on host immunity

2021

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The microbiome plays a fundamental role in the maturation, function, and regulation of the host-immune system from birth to old age. In return, the immune system has co-evolved a mutualistic relationship with trillions of beneficial microbes residing our bodies while mounting efficient responses to fight invading pathogens. As we age, both the immune system and the gut microbiome undergo significant changes in composition and function that correlate with increased susceptibility to infectious diseases and reduced vaccination responses. Emerging studies suggest that targeting age-related dysbiosis can improve health- and lifespan, in part through reducing systemic low-grade inflammation and immunosenescence—two hallmarks of the aging process. However—a cause and effect relationship of age-related dysbiosis and associated functional declines in immune cell functioning have yet to be demonstrated in clinical settings. This review aims to (i) give an overview on hallmarks of the aging immune system and gut microbiome, (ii) discuss the impact of age-related changes in the gut commensal community structure (introduced as microb-aging) on host-immune fitness and health, and (iii) summarize prebiotic- and probiotic clinical intervention trials aiming to reinforce age-related declines in immune cell functioning through microbiome modulation or rejuvenation.

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Effects of Lactobacillus coryniformis K8 CECT5711 on the immune response to influenza vaccination and the assessment of common respiratory symptoms in elderly subjects: a randomized controlled trial

Cited by 37 publications

References 26 publications

Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial

Effect of fermented milk on upper respiratory tract infection in adults who lived in the haze area of Northern China: a randomized clinical trial

The Potential Role of Probiotics in Protection against Influenza a Virus Infection in Mice

The aging gut microbiome and its impact on host immunity

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