Effects of liquisolid formulations on dissolution of naproxen

Tiong, N; Elkordy, Amal

doi:10.1016/j.ejpb.2009.08.002

Cited by 161 publications

(114 citation statements)

References 19 publications

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“…The Φ-value corresponding to an angle of slide of 33° represented the flowable liquid retention potential (Φ-value) of that material. The Phi value for carrier and coating material has been abbreviated as Φ CA and Φ CO respectively 14,15 .…”

Section: Flowablementioning

confidence: 99%

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2017

IJPSR

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Olmesartan medoxomil, a BCS class II drug, is an angiotensin-II receptor antagonist used for the treatment of hypertension. A liquisolid tablet of Olmesartan medoxomil was developed to improve its dissolution and flow properties. The commonly used carrier Avicel was compared with Neusilin. Because of higher liquid load factor, Neusilin was selected as a carrier for further optimization study using 3 2 Factorial design. Two independent factors, % drug concentration in a liquid vehicle (X1) and carrier coating ratio (X2) were studied, each with three levels and the systems was assessed for two dependent variables; % drug dissolution and angle of repose. Mathematical equations and response surface plots were used to relate the dependent and independent variables. All prepared liquisolid formulations were characterized for pre-and post-compression parameters. The optimized formulation F7 (15% drug concentration and 30 carrier coating ratio) was tested for X-ray powder diffractometry and FTIR. Results showed that maximum drug dissolution was exhibited by systems with minimum drug concentration in liquid vehicle and optimum carrier to coating ratio. Optimized formulation displayed significantly enhanced dissolution profiles than that of marketed formulation. In conclusion, avicel could be replaced by neusilin for the formulation of low weight liquisolid tablets along with increased dissolution.

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Section: Flowablementioning

confidence: 99%

“…Appropriate aliquots were withdrawn at a suitable time interval (5,10,15,20,30, 45 and 60 min.) and filtered through 0.45µm filter paper and diluted as per need with phosphate buffer pH 6.8.…”

Section: In Vitro Drug Dissolution Studymentioning

confidence: 99%

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2017

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“…This P-glycoprotein decreases the drug intestinal absorption by efflux transportation and hence reduces its plasma concentration (18,(49)(50)(51)(52). Also Kollicoat ® SR 30D (polyvinyl acetate stabilized with polyvinylpyrrolidone and sodium lauryl sulphate) can be used as a liquid vehicle in liquisolid systems for controlled drug release (52,53).…”

Section: Excipients For Liquisolid Systemsmentioning

confidence: 99%

“…1). The most promising and innovative technique for promoting dissolution and in vivo bioavailability of poorly soluble drugs is the formulation of liquisolid systems (LSS) (5,17,18).…”

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confidence: 99%

Liquisolid systems and aspects influencing their research and development

Vraníková¹,

Gajdziok²

2013

Acta Pharmaceutica

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“…Finally, this study reported that MCC PH 101 is a suitable carrier for preparing liquisolid systems in terms of having acceptable flowability, friability, hardness, and dissolution profile. Tiong N et al (2009) reported that naproxen properties were changed by adding non-volatile hydrophilic solvent, leading to an increase in dissolution properties and possibly oral bio-availability.…”

Section: Pre Compression Studiesmentioning

confidence: 99%

The Liquisolid technique: an overview

Burra¹,

Yamsani²,

Venkateswarlu³

2011

Braz. J. Pharm. Sci.

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A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are used as vehicles.Uniterms: Liquisolid. Solubility. Bioavailability. Flow properties. Load factor. Powder solution technology.A nova "Tecnologia da Solução Sólida" envolve eficiência de absorção e de adsorção, faz uso de medicações líquidas, suspensões de fármacos e misturas com transportadores adequados, materiais de cobertura e é formulada em formas sólidas em fluxo livre, secas, não aderentes e compressíveis. Com base em novo modelo matemático, características aprimoradas de fluxo e dureza da formulação foram alcançadas modificando-se a proporção de Avicel ® PH 200 e Aerosil ® PH 200 de 50:1 para 5:1, na qual o fármaco é disperso quase que no estado molecular. Devido às propriedades de umidificação significativamente aprimoradas e à área do fármaco exposta ao meio de dissolução, que resulta na velocidade de dissolução, a biodisponibilidade foi aumentada. Utilizando a técnica Liquisólido, desenvolveram-se sistemas de liberação controlada de fármacos solúveis em água, nos quais solventes hidrofóbicos não voláteis foram usados como veículos.Unitermos: Liquisólido. Solubilidade. Biodisponibilidade. Propriedades de fluxo. Fator de carga. Tecnologia de solução sólida.

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Effects of liquisolid formulations on dissolution of naproxen

Cited by 161 publications

References 19 publications

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Liquisolid systems and aspects influencing their research and development

The Liquisolid technique: an overview

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