Effects of low-intensity laser therapy on periodontal tissue remodeling during relapse and retention of orthodontically moved teeth

Kim, Su Jung; Kang, Yoon‐Goo; Park, Jong Hyun; Kim, Eun Cheol; Park, Young-Guk

doi:10.1007/s10103-012-1146-8

Cited by 37 publications

(24 citation statements)

References 37 publications

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“…Previous researches described that the PBM, associated or not with osteoinductive biomaterials, may significantly reduce root resorptions. 9,13,15 Although no osteopromotive material have been analyzed in our study, we hypothesize that the PBM using the dosage of 640 J/cm 2 could promote the inhibition of tooth root resorption processes; however, more investigations must be performed to better understanding of this histomorphological finding.…”

Section: Discussionmentioning

confidence: 98%

“…In the current study, PBM-mediated biostimulatory effects were produced on the periodontal tissue, submitted to orthodontic tooth movement, in diabetic and normoglycemic rats, being similar to previous reports found in literature. 9,10,11,15 A recent review by Kim et al 13 suggest that the PBM used in orthodontics improves permeability of cell wall and influx of Ca ++ , enhances ATP production and collagen synthesis, increases pro-inflammatory and anti-inflammatory cytokines, as well as activates several proteolytic enzymes essential for extracellular matrix remodeling, PDL 50µm Figure 6. Representative immunohistochemical reactivity (arrows) for OPN in the 640J-LD group.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the photobiomodulation (PBM), previously known as low-level laser therapy (LLLT), has showed great effectiveness due to its analgesic, anti-inflammatory and photobiostimulatory properties, resulting in a faster tooth movement with no periodontal tissue side effects. 9,10,11,12,13,14,15,16,17 However, one of the key issues is to find an appropriate energy density for different experimental and clinical trials.…”

Section: Introductionmentioning

confidence: 99%

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Effects of the photobiomodulation using different energy densities on the periodontal tissues under orthodontic force in rats with type 2 diabetes mellitus

Gomes¹,

Goulart²,

Giannasi³

et al. 2018

Braz. oral res.

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To evaluate the impact of the GaAlAs diode laser with energy densities of 160 J/cm 2 , 320 J/cm 2 , and 640 J/cm 2 on the periodontal tissues under continuous orthodontic force application and on the rate of orthodontic tooth movement in rats with type-2 diabetes mellitus. The intensity of primary alveolar bone formation was also investigated through the immune-positive osteocytes for OPN antibody. Forty adult male Wistar rats were divided into eight groups of 5 rats: normoglycemic (N), 160 J-laser-normoglycemic (160 J-LN), 320 J-laser-normoglycemic (320 J-LN), 640 J-laser-normoglycemic (640 J-LN), diabetic (D), 160 J-laser-diabetic (160 J-LD), 320 J-laser-diabetic (320 J-LD), and 640 J-laser-diabetic (640 J-LD) rats. Diabetes mellitus was induced by a single intravenous injection of 40 mg/kg monohydrated-alloxan. An orthodontic force magnitude of 20cN was applied. The laser parameters were continuous emission of 780-nm wavelength, output power of 20mW, and fiber probe with a spot size of 0.04 cm in diameter. Radiographic, histomorphological, and immunohistochemical analysis were performed after a period of 21 days. The photobiomodulation using the energy density of 640 J/cm 2 strongly stimulated the alveolar bone formation and contributed the reorganization of the soft periodontal tissues, followed by the 320 J/cm 2 . Extensive alveolar bone loss, intense infiltration of inflammatory cells, and degradation of the PDJ tissue were mainly found in the D and 160 J-LD groups. The rate of orthodontic tooth movement was represented by the interdental distance between the cementoenamel junctions of the right mandibular first and second molars. This distance was larger in the diabetic groups (D: 39.98±1.97, 160 J-LD: 34.84±6.01, 320 J-LD: 29.82±1.73, and 640 J-LD: 35.47±4.56) than in the normoglycemic groups (N: 21.13±1.19; 160 J-LN: 22.69±0.72, 320 J-LN: 22.28±0.78, and 640 J-LN: 24.56±2.11). The number of osteopontin-positive osteocytes was significantly greater in the 640 J-LD (14.72 ± 0.82; p < 0.01) and 640 J-LN (13.62 ± 1.33; p < 0.05) groups than with D (9.82 ± 1.17) and 160 J-LD (9.77 ± 1.10) groups. Therefore, the energy density of 640 J/cm 2 provided the best maintenance and integrity of the periodontal tissue microarchitecture under continuous orthodontic force when compared with the other dosages, mainly in the uncontrolled diabetic rats. The interdental distance was greater in the D and 160 J-LD groups due to presence of severe periodontitis caused by diabetes plus the mechanical stress generated by continuous orthodontic forces, implying, thus, an insufficient biostimulatory effect for the dosage of 160 J/cm 2 .

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of the photobiomodulation using different energy densities on the periodontal tissues under orthodontic force in rats with type 2 diabetes mellitus

Gomes¹,

Goulart²,

Giannasi³

et al. 2018

Braz. oral res.

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show abstract

“…12,13 LLLT on moved teeth without retainers increased the relapse rate while maintaining a balance between collagen degradation and synthesis in the activated remodeling state. In contrast, LLLT on teeth fixed with retainers facilitated collagen synthesis exceeding collagen degradation, which could be indicated by the relative expression levels of MMPs and collagen in the PDL.…”

Section: Introductionmentioning

confidence: 95%

Combined effect of photobiomodulation with a matrix metalloproteinase inhibitor on the rate of relapse in rats

Lee

Kim

Anderson

et al. 2015

The Angle Orthodontist

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Objective: To investigate combined effect of photobiomodulation with a matrix metalloproteinase (MMP) inhibitor on the relapse rate in relation to MMP expression in rats. Materials and Methods: Fifty-two rats were divided into four groups according to the treatment modality: control group, irradiation group, doxycycline group, and irradiation with doxycycline group. During a relapse period of 5 days after orthodontic movement, maxillary central incisors were treated by low-level laser therapy (LLLT) as a photobiomodulation and/or doxycycline as a synthetic MMP inhibitor. Relapse rate was evaluated in association with MMP expression at the gene and protein levels. Results: Relapse rates were increased by LLLT (1.57-fold) and decreased by doxycycline (0.83-fold) compared with the control, showing positive correlation with the levels of expression for all MMPs in the periodontal ligament (PDL). LLLT concomitant with doxycycline administration resulted in no significant differences of relapse rate and MMP expression from the control. Conclusions: The combined effect of photobiomodulation with an MMP inhibitor around the relapsing teeth proved to be antagonistic to PDL remodeling activity during relapse. This study suggests a basis for developing a novel biologic procedure targeting the MMP-dependent PDL remodeling to control the relapse rate. (Angle Orthod. 2016;86:206-213.)

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“…1,3,4,5,[7][8][9][10][11][12][14][15][16][17][18]20,[23][24][25][26] We describe four fundamental points for experimental models to ensure that the evaluation of the effects of medication and phototherapy on induced tooth movement and associated root resorption is free of external influence.…”

Section: Palavras-chavementioning

confidence: 99%

Effects of medications and laser on induced tooth movement and associated root resorption: four key points

Consolaro

2013

Dental Press J. Orthod.

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The following four fundamental points on the use of experimental models will be described to ensure an accurate evaluation of the effects of medication and laser therapy on induced tooth movement and associated root resorption: (1) If the objective is to check the effect on root resorption, the forces experimentally applied must produce a lesion on the cementoblast layer in all specimens; (2) If the objective is to optimize induced tooth movement and reduce treatment time without side effects, the forces experimentally applied should not produce a lesion in the cementoblast layer in any specimen; (3) The laser therapy operator, the person administering medication and the person that places appliances should not know which animals will effectively receive the test treatment, and the control groups should receive placebo treatments; (4) CT and microscopic analysis of the specimens should be random, and the group to which the specimen belongs should not be identified to ensure that the person reading images and the pathologists are not influenced in their evaluation of phenomena. These measures will ensure that results are more reliable and easier to extrapolate to orthodontic clinical practice.

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Effects of low-intensity laser therapy on periodontal tissue remodeling during relapse and retention of orthodontically moved teeth

Cited by 37 publications

References 37 publications

Effects of the photobiomodulation using different energy densities on the periodontal tissues under orthodontic force in rats with type 2 diabetes mellitus

Effects of the photobiomodulation using different energy densities on the periodontal tissues under orthodontic force in rats with type 2 diabetes mellitus

Combined effect of photobiomodulation with a matrix metalloproteinase inhibitor on the rate of relapse in rats

Effects of medications and laser on induced tooth movement and associated root resorption: four key points

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