Effects of maternal age on reproductive performance of the southern medicinal leech, Hirudo verbana Carena, 1820

Ceylan, Mustafa

doi:10.1016/j.anireprosci.2020.106507

Cited by 11 publications

(5 citation statements)

References 18 publications

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“…However, H. nipponia has a prolonged maturation cycle with low reproduction ability as the H. nipponia begins to lay eggs in the second year. The average number of spawning cocoons of H. nipponia was the lowest compared with Whitmania pigra Whitman and Hirudinaria Poecilobdella manillensis ( Ceylan, 2020 ).…”

Section: Introductionmentioning

confidence: 86%

“…Physiologically, leeches are narrow, slightly flattened, cylindrical, and small-sized creatures used as raw material in Chinese traditional medicine with diverse functioning such as anticoagulation, exorcizing blood stasis, and promoting menstruation ( Saglam, 2019 ). They are hermaphroditic where the male part matures first and then mates heterozygously, and oviparously ( Ceylan, 2020 ). After hatching, leech seedlings moult once every 10 days, leeches grow for one age after one molt, 30–90 days is the optimum growth period for leeches, and it takes approximately 80 days to grow from seedling to adult size ( Manav et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Comparative Transcriptome Sequencing Analysis of Hirudo nipponia in Different Growth Periods

Yan

et al. 2022

Front. Physiol.

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Hirudo nipponia is the only blood-sucking leech included in Chinese Pharmacopoeia having distinct features of anticoagulation, exorcizing blood stasis, and promoting menstruation. Despite such significant characteristics, very little is known about its molecular genetics and related physiological mechanisms. In this study, the transcriptomes of H. nipponia at three developmental stages (larvae, young, and adults), revealed a total of 1,348 differentially expressed genes (DEGs), 223 differentially expressed lncRNAs, and 88 novel mRNAs. A significant diverse gene expression patterns were observed at different developmental stages which were analyzed by differential gene expression trends, and the overall gene expression trends consist of three overall down-regulated trends, and two overall up-regulated trends. Furthermore, the GO and KEGG enrichment functional annotation analysis revealed that these DEGs were mainly associated with protein hydrolysis, signal transduction, energy metabolism, and lipid metabolism while growth, development, metabolism, and reproduction-related DEGs were also found. Additionally, real-time quantitative PCR results confirmed deep sequencing results based on the relative expression levels of nine randomly selected genes. This is the first transcriptome-based comprehensive study of H. irudo nipponia at different developmental stages which provided considerable deep understanding related to gene expression patterns and their relevant developmental pathways, neurodevelopmental and reproductive characteristics of the leech.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptome Sequencing Analysis of Hirudo nipponia in Different Growth Periods

Yan

et al. 2022

Front. Physiol.

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“…Physicians are obliged to know the sterility status of leeches The risk of pathogen transmission in leeches collected from nature, decreasing leech populations, and increasing leech prices have made medicinal leech breeding important (38,39). however, the fact that the breeding protocols are not well-known makes leech breeding unprofitable and cause the leech demand to be insufficiently met (29,40). This again increases the possibility that the leeches used in hirudotherapy are those collected from nature.…”

Section: Introductionmentioning

confidence: 99%

What Is Need To Be Known About Medicinal Leeches And Hirudotherapy?: A Comprehensive Review

BECANIM,

BERKTAŞ,

CEYLAN

2022

Journal of Anatol Medicine

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Since ancient times humans have used a variety of plants and animals to both prevent and treat ailments. Hirudotherapy is a traditional treatment modality using medicinal leeches. In both traditional and modern medicine, medicinal leeches have been important in the treatment of eczema, chronic ulcers, psoriasis, osteoarthritis, thrombosis, and hypertension. Hirudotherapy is a trustworthy, easy-to-use, helpful, and affordable treatment option for draining blood from deeper tissues in localized venous congestion related with surgical replantations and flap reconstructions. Hirudotherapy has also been commonly used to treat soft tissue oedema and haematomas in trauma situations. Throughout the feeding process, leeches secrete biologically and pharmacologically active components into the wound. This article aims to present a broad assessment of the potential use of hirudotherapy, indications, contraindications, and therapy-related complications. Providing detailed evidence-based information about the usage areas of hirudotherapy will help spread healthy medicinal leech practices and prevent possible complications, thus infectious diseases and public health problems.

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“…The enzymes secreted by medicinal leeches are used in the production of some drugs and cosmetic products (Ayhan and Mollahaliloğlu, 2018;Lemke and Vilcinskas, 2020;Shakouri and Wollina, 2021). Medicinal leeches play some important roles in aquatic ecosystems (Ceylan et al, 2015); however, because of over-collection and habitat destruction, medicinal leech populations have been weakening day by day in many wetlands (Sağlam, 2011;Ceylan andÇetinkaya, 2017, Sağlam, 2018). It is a necessity, therefore, to take protective measures for the sustainable management of medicinal leech populations.…”

Section: Introductionmentioning

confidence: 99%

“…Zinc leads the aquatic organisms to death with its cytotoxic effect (Kodama et al, 1982), as well as the acid-base balance and due to the negative effects on the regulation of ions (Senthil Murugan et al, 2008). Because medicinal leeches are among the endangered species (Sağlam, 2011;Sağlam et al, 2018;Ceylan, 2020;Kvist et al, 2020), determining the toxicologic limits becomes important to maintain sustainable management.…”

Section: Introductionmentioning

confidence: 99%

Acute Toxicity of Zinc on Southern Medicinal Leech, Hirudo verbana Carena, 1820

Ceylan¹,

Çetinkaya²,

Bulut³

2021

Acta Aquatica Turcica

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In the present study it was aimed to determine the acute toxicity of zinc on southern medicinal leech Hirudo verbana Carena, 1820 that being used in the ecotoxicological studies. The experiment was conducted for 96 hours using the semi-static bioassay method with replicate two times. The leeches were exposed to zinc concentrations of 6.25 mg/L, 12.50 mg/L, 25 mg/L, 50 mg/L, 100 mg/L and 200 mg/L, respectively. As a result of the experiment, the LC50 values for 24, 48, 72 and 96 hours were determined 48.30 mg/L, 19.68 mg/L, 15.48 mg/L, and 14.12 mg/L, respectively. The LT50 values for 25 mg/L, 50 mg/L, 100 mg/L and 200 mg/L zinc concentrations were determined 38.63 hours, 24.55 hours, 14.62 hours, and 12.78 hours, respectively. Defecation, intensive mucus output, uncontrolled swimming, attempt to escape from the experiment media, reducing the cling power, coiling (buckling), vomiting the digestive blood, the body deformations, penile prolapse, hemorrhage and abrasion in the wall of the body were the main physiological and behavioral responses in the leeches which were exposed to the different zinc solutions. The data obtained revealed that the zinc sensitivity of H. verbana was moderate when compared to other organisms. It is expected that the data of the present study will contribute to the management of endangered medicinal leech populations.

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Effects of maternal age on reproductive performance of the southern medicinal leech, Hirudo verbana Carena, 1820

Cited by 11 publications

References 18 publications

Comparative Transcriptome Sequencing Analysis of Hirudo nipponia in Different Growth Periods

Comparative Transcriptome Sequencing Analysis of Hirudo nipponia in Different Growth Periods

What Is Need To Be Known About Medicinal Leeches And Hirudotherapy?: A Comprehensive Review

Acute Toxicity of Zinc on Southern Medicinal Leech, Hirudo verbana Carena, 1820

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