Effects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age

Akbari, Sara; Rabbani, Mohammad; Sharifzadeh, Mohammad; Hosseini-Sharifabad, Ali

doi:10.29252/arakmu.11.1.43

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2020

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“…Propranolol hydrochloride, 1-[isopropylamino-3-[1-naphthyloxy]-2-propanol hydrochloride (I), is β-blocker drug and used to control hypertension, cardiac arrhythmia, myocardial and hyperthyroidism diseases [2][3][4][5]. Methyldopa, αmethyl-3,4-dihydroxyphenylalanine (II) is used as an antihypertensive agent and effective inhibitor for the dopa-decarboxylase enzyme to lower blood pressure [6,7].…”

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confidence: 99%

Spectrophotometric Method for Indirect Determination Of Antihypertensive Drugs in Pharmaceuticals

Dhamra

2020

Egypt. J. Chem.

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A spectrophotometric method is proposed for the determination of antihypertensive drugs namely Propranolol and Methyldopa in their pure forms and in pharmaceutical formulations, based on the oxidation of the drugs with an excess of N-Bromo succinimide and the residual oxidizing agent bleaches the red colored eriochrom black-T (EBT) which is measured at 530 nm at room temperature. Linear calibration graphs were obtained in the concentration range 0.1-10 and 0.1-9 μg ml -1 with molar absorptivity 6.06×10 4 and 4.60×10 4 L.mol -1 .cm -1 for above drugs respectively. No interference was observed coexistent substance. The proposed method was applied successfully for the determination of the drugs in their pharmaceutical formulations.

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Section: Introductionmentioning

confidence: 99%

Spectrophotometric Method for Indirect Determination Of Antihypertensive Drugs in Pharmaceuticals

Dhamra

2020

Egypt. J. Chem.

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Effects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age

Abstract: Background: Alpha Methyldopa (AMD) is a well-known treatment for the pregnancy induced

Cited by 1 publication

References 20 publications

Spectrophotometric Method for Indirect Determination Of Antihypertensive Drugs in Pharmaceuticals

Spectrophotometric Method for Indirect Determination Of Antihypertensive Drugs in Pharmaceuticals

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