Effects of Medicinal Drugs on Fitness to Drive

Theunissen, Eef L.; Kuypers, Kim P. C.; Vermeeren, Annemiek; Vuurman, E.F.P.M.; Ramaekers, Johannes G.

doi:10.1002/9781118570654.ch60

Handbook of Forensic Medicine 2014

DOI: 10.1002/9781118570654.ch60

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Effects of Medicinal Drugs on Fitness to Drive

Eef L. Theunissen¹,

Kim P. C. Kuypers²,

Annemiek Vermeeren³

et al.

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2017

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A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L

et al. 2017

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IntroductionThe on-the-road highway driving test is generally regarded as a gold standard for assessing drug-induced driving impairment. The primary outcome measure is the standard deviation of lateral position (SDLP), a measure of road tracking error or “weaving”. The test has been calibrated for incremental doses of alcohol almost 30 years ago in order to define the impact of drug-induced impairment in terms of blood alcohol concentration (BAC) equivalents. Drug-induced changes in SDLP exceeding 2.4 cm have been evaluated as clinically relevant ever since. The present analysis was conducted to assess the robustness of the alcohol effect in a range of on-the-road driving studies which have been conducted since the initial alcohol calibration study.MethodsThe present study pooled data of 182 participants from nine placebo-controlled crossover studies who performed the highway driving test, while their BAC was at or just below the legal limit for drivers (i.e., 0.5 g/L).ResultsOverall, mean SDLP increased with 2.5 cm (95% CI 2.0–2.9 cm). Equivalence testing showed that the clinical relevance criterion value of 2.4 cm fell well within the 95% CI in each individual study. Gender did not affect alcohol-induced changes in SDLP.DiscussionThese results demonstrate the robustness and validity of the clinical relevance criterion for SDLP as measured during on-the-road driving.

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A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L

et al. 2017

View full text Add to dashboard Cite

show abstract

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Effects of Medicinal Drugs on Fitness to Drive

Cited by 1 publication

References 53 publications

A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L

A pooled analysis of on-the-road highway driving studies in actual traffic measuring standard deviation of lateral position (i.e., “weaving”) while driving at a blood alcohol concentration of 0.5 g/L

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