Effects of mitochondria on postmortem meat quality: characteristic, isolation, energy metabolism, apoptosis and oxygen consumption

Zou, Bo; Jia, Fei; Lin, Jianhan; Li, Xingmin; Dai, Ruitong

doi:10.1080/10408398.2023.2235435

Cited by 14 publications

(9 citation statements)

References 192 publications

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“…In this study, MMP declined with postmortem time, reaching its lowest level at 4 days (Figure B). Caspase-3, known as the apoptosis executioner, has the capability of directly triggering apoptotic cell death . The caspase-3 activity in beef muscle showed an increasing trend for the first 24 h postmortem, indicating a rising apoptotic process (Figure C).…”

Section: Resultsmentioning

confidence: 99%

“…Caspase-3, known as the apoptosis executioner, has the capability of directly triggering apoptotic cell death. 3 The caspase-3 activity in beef muscle showed an increasing trend for the first 24 h postmortem, indicating a rising apoptotic process (Figure 3C). Subsequently, caspase-3 activity decreased, probably due to the death of most muscle cells and a decrease in activated caspase-3.…”

Section: Changes Of Muscle Ros Mmp Caspase-3 Activity and Mfi During ...mentioning

confidence: 94%

“…Apoptosis, an orderly and autonomous process of cell death controlled by multiple genes, plays a crucial role in maintaining the stability of the internal cellular environment. Characterized by cell shrinkage, disruption of membrane integrity, chromatin condensation and breakage, and increased cytoplasmic lysosomal enzyme activity, apoptosis culminates in cellular recognition and phagocytosis. , In postmortem muscle, apoptosis has emerged as an active biological process influenced by various factors, including postmortem time, muscle type, and animal breed . This process potentially regulates the tenderization of postmortem muscle. , In the early postmortem period, the expression of mitochondrial cytochrome c increases, flowing through mitochondria to cytoplasm and promoting apoptosis.…”

Section: Introductionmentioning

confidence: 99%

“…Characterized by cell shrinkage, disruption of membrane integrity, chromatin condensation and breakage, and increased cytoplasmic lysosomal enzyme activity, apoptosis culminates in cellular recognition and phagocytosis. , In postmortem muscle, apoptosis has emerged as an active biological process influenced by various factors, including postmortem time, muscle type, and animal breed . This process potentially regulates the tenderization of postmortem muscle. , In the early postmortem period, the expression of mitochondrial cytochrome c increases, flowing through mitochondria to cytoplasm and promoting apoptosis. As postmortem time prolongs, the levels of cytochrome c in both mitochondria and cytoplasm decrease. , BAX, when elevated, accelerates muscle mitochondrial rupture, leading to the release of mitochondrial apoptotic factors .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 In postmortem muscle, apoptosis has emerged as an active biological process influenced by various factors, including postmortem time, muscle type, and animal breed. 3 This process potentially regulates the tenderization of postmortem muscle. 3,4 In the early postmortem period, the expression of mitochondrial cytochrome c increases, flowing through mitochondria to cytoplasm and promoting apoptosis.…”

Section: ■ Introductionmentioning

confidence: 99%

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Identifying the Potential Apoptotic Metabolites in Postmortem Beef Muscle by Targeted Metabolomics

Zou,

Wang,

Duan

et al. 2024

J. Agric. Food Chem.

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Apoptotic cells may release specific metabolites to act as messengers during the apoptotic process. This study represents the first attempt to identify potential apoptotic metabolites in postmortem muscle. Ninety potential apoptotic metabolites in beef were selected and analyzed through targeted metabolomics, with 84 of them exhibiting significant differences over the postmortem time. Following the addition of the mitochondria-targeted antiapoptotic agent mitoquinone to postmortem muscle, metabolomic analysis revealed that 73 apoptotic metabolites still underwent significant changes, even against the backdrop of altered apoptosis. Of these 73 apoptotic metabolites, 54 exhibited similar trends at various treatment times with adding mitoquinone, including lipids (6), amino acids (27), nucleosides (11), and carbohydrate and energy metabolism (10). Mitoquinone significantly reduced the levels of most apoptotic metabolites, and inhibition of apoptosis resulted in a significant decrease in the levels of numerous apoptotic metabolites. Consequently, these apoptotic metabolites are considered complementary to apoptosis in postmortem muscle, with their increased levels potentially promoting apoptosis. Noteworthy apoptotic metabolites, such as glycerol 3-phosphate, serine, AMP, ATP, GMP, and creatine, were identified as active signaling molecules that attract and recruit phagocytes during apoptosis, assisting in recognizing apoptotic cells by phagocytes. This study provides, for the first time, insights into potential apoptotic metabolites in postmortem muscle, contributing to a better understanding of meat biochemistry.

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Section: Resultsmentioning

confidence: 99%

Section: Changes Of Muscle Ros Mmp Caspase-3 Activity and Mfi During ...mentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Identifying the Potential Apoptotic Metabolites in Postmortem Beef Muscle by Targeted Metabolomics

Zou,

Wang,

Duan

et al. 2024

J. Agric. Food Chem.

Self Cite

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Differential regulation of physicochemical properties and myofibrillar protein degradation of yak meat by interactions between reactive oxygen species and reactive nitrogen species during postmortem aging

Yang,

Bu,

et al. 2024

J Sci Food Agric

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BACKGROUNDThis study aimed to explore how interactions between reactive oxygen species (ROS) and reactive nitrogen species (RNS) affect oxidative properties, nitrosative properties, and myofibrillar protein degradation during postmortem aging of yak meat.RESULTSYak longissimus dorsi was incubated with saline, ROS activator (H2O2)/inhibitor N‐Acetyl‐L‐cysteine (NAC) and RNS activator S‐Nitrosoglutathione (GSNO)/inhibitor L‐NAME hydrochloride (L‐NAME) combined treatments at 4 °C for 12, 24, 72, 120, and 168 h. The results indicated that regardless of whether RNS was activated or inhibited, activated ROS played a dominant role in myofibrillar protein degradation by oxidative modification to increase carbonyl content, disulfide bonds, surface hydrophobicity, and dimerized tyrosine while decreasing sulfhydryl content, thereby degrading nebulin, titin, troponin‐t and desmin. Notably, the Warner–Bratzler shear force (WBSF) of the H2O2 + L‐NAME group was the smallest, whereas that of the NAC + GSNO group was smaller than that of the NAC + L‐NAME group.CONCLUSIONThese findings provide new insights into meat tenderization patterns through the interaction between ROS and RNS. © 2024 Society of Chemical Industry.

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Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity

Li,

Yin,

Dong

et al. 2024

Biol Trace Elem Res

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Effects of mitochondria on postmortem meat quality: characteristic, isolation, energy metabolism, apoptosis and oxygen consumption

Cited by 14 publications

References 192 publications

Identifying the Potential Apoptotic Metabolites in Postmortem Beef Muscle by Targeted Metabolomics

Identifying the Potential Apoptotic Metabolites in Postmortem Beef Muscle by Targeted Metabolomics

Differential regulation of physicochemical properties and myofibrillar protein degradation of yak meat by interactions between reactive oxygen species and reactive nitrogen species during postmortem aging

Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity

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