Effects of Morphine and Ketamine Anaesthesia and Surgery on Plasma Concentrations of Luteinizing Hormone, Testosterone and Cortisol in Man

Oyama, Tsutomu; Toyota, M.; Shinozaki, Y.; Kudo, Tsuyoshi

doi:10.1097/00132586-197812000-00038

Cited by 3 publications

(4 citation statements)

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“…Ketamine has been reported to significantly reduce sperm motility, viability and normal chromatin dispersion (Absalan, Ghannadi, & Zabihi, 2014). This corroborates earlier findings that observed that ketamine led to testosterone suppression (Oyama, Toyota, Shinozaki, & Kudo, 1977; Carter et al, 1984). Ketamine‐induced reproductive dysfunction has been shown to be, at least in part, via a calcium‐dependent mechanism.…”

Section: Drug Abusesupporting

confidence: 92%

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Ajayi

Akhigbe

2020

Andrologia

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Infertility is the failure of a couple to achieve conception after 12 months of adequate unprotected sexual intercourse (Wiwanitkit, 2008). It is a major health challenge with social implications among couples, particularly in the tropics (Yeşilli et al., 2005). Although Mascarenhas, Cheung, Mathers, and Stevens (2012) suggested a dearth of data on the global prevalence of infertility, Boivin, Bunting, Collins, and Nygren (2007) documented that about 72.4 million couples experience fertility problems globally. This accounts for about 15% of couples (Dissanayake, Keerthirathna, & Peiris, 2019). Contrary to the popular misconception that infertility is attributable to female factor, it has been established that about 30%-50% cases of primary infertility is due to male factor (Ajayi &

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Section: Drug Abusesupporting

confidence: 92%

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Ajayi

Akhigbe

2020

Andrologia

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“…Ketamine‐treated embryos showed an increase in testosterone level, which is in agreement with data reported in male boars (Estienne and Barb ), male collared peccary ( Tayassu tajacu ) (Hellgren et al ., ) and female Norway rats (Gould, ). In contrast, ketamine has been shown to cause a reduction in plasma testosterone levels in men (Oyama et al ., ), domestic tom cats (Johnstone and Bancroft, ) and cyclic female Sprague–Dawley rats (Lee et al ., ). In humans, although there have been some reports of decreased testosterone levels after general anesthesia, possibly owing to surgical trauma, more often an increase in the testosterone level occurred with ketamine anesthesia 1 h after surgery (Cartensen et al ., 1973).…”

Section: Discussionmentioning

confidence: 99%

Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol‐17β levels in zebrafish early life stages

Trickler

Guo

Cuevas

et al. 2013

J of Applied Toxicology

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Ketamine, a dissociative anesthetic, is a noncompetitive antagonist of N-methyl-D-aspartate-type glutamate receptors. In rodents and non-human primates as well as in zebrafish embryos, ketamine has been shown to be neurotoxic. In cyclic female rats, ketamine has been shown to decrease serum estradiol-17β(E2) levels. E2 plays critical roles in neurodevelopment and neuroprotection. Cytochrome p450 (CYP) aromatase catalyzes E2 synthesis from androgens. Although ketamine down-regulates a number of CYP enzymes in rodents, its effect on the CYP aromatase (CYP19) is not known. Zebrafish have been used as a model system for examining mechanisms underlying drug effects. Here, using wild-type (WT) zebrafish (Danio rerio) embryos, we demonstrate that ketamine significantly reduced E2 levels compared with the control. However, the testosterone level was elevated in ketamine-treated embryos. These results are concordant with data from mammalian studies. Ketamine also attenuated the expression of the ovary form of CYP aromatase (cyp19a1a) at the transcriptional level but not the brain form of aromatase, cyp19a1b. Exogenous E2 potently induced the expression of cyp19a1b and vtg 1, both validated biomarkers of estrogenicity and endocrine disruption, but not cyp19a1a expression. Attenuation of activated ERK/MAPK levels, reportedly responsible for reduced human cyp19 transcription, was also observed in ketamine-treated embryos. These results suggest that reduced E2 levels in ketaminetreated embryos may have resulted from the suppression of cyp19a1a transcription. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

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“…concentrations of LH (Oyama et al 1977). It has been shown that anaesthesia of ovariectomized gilts with ketamine resulted in a decrease in serum concentrations of LH while increasing serum concentrations of cortisol (Popwell et al 1996).…”

Section: Discussionmentioning

confidence: 99%

“…However, ketamine anaesthesia was found to inhibit pulsatile LH release in ovariectomized steroid-primed rats (Yilmaz & Gilmore 1999). Administration of ketamine to humans has been shown to cause a marked stimulation of adrenocortical function and an increase in plasma concentrations of LH (Oyama et al 1977). In the pig, administration of ketamine has been shown to decrease serum concentrations of LH and increase serum concentrations of cortisol in gilts (Popwell et al 1996).…”

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confidence: 99%

Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts

Clapper

2008

Lab Anim

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SummaryTo determine if administration of the anaesthetic cocktail, telazol-ketamine -xylazine (TKX) and pentothal (PEN) decreases serum concentrations of luteinizing hormone (LH) in pigs, the following experiment was performed. On day 1, eight gilts and six barrows of similar weight (75 kg) were anaesthetized with TKX (1 mL/22.5 kg body weight [BW] intramuscularly) and indwelling jugular catheters were inserted. On days 2, 6 and 8 blood samples were taken every 20 min, for 4 h before pigs were administered saline (day 2) or anaesthetized with TKX (day 6) and PEN (8.9 mg/kg BW intravenously, day 8). Blood samples were taken every 20 min for 4 h following administration of saline and anaesthetics. Mean serum concentrations of LH and cortisol did not differ (P . 0.05) within barrows or gilts from before administration of saline (day 2) to following saline administration. Mean serum concentrations of LH and cortisol were not different (P . 0.05) within barrows and gilts before administration of TKX ( pre-TKX) or PEN compared with day 2 samples. Following administration of TKX ( post-TKX), mean serum concentrations of LH decreased (P , 0.05) and remained decreased for 140 min, while mean serum concentrations of cortisol increased (P , 0.05) post-TKX and remained elevated for 140 min. In gilts, mean serum concentrations of LH did not differ (P . 0.05) from pre-to post-TKX. However, mean serum concentrations of cortisol increased (P , 0.05) post-TKX in gilts and remained elevated for 240 min. Following administration of PEN, mean serum concentrations of LH and cortisol within barrows and gilts were not different (P . 0.05) from concentrations before administration of PEN. Administration of TKX to barrows and gilts increased serum concentrations of cortisol, but transient decreases in serum concentrations of LH were observed only in barrows, indicating gonadal status and/or sex may influence the ability of TKX to alter circulating concentrations of LH in pigs.

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Effects of Morphine and Ketamine Anaesthesia and Surgery on Plasma Concentrations of Luteinizing Hormone, Testosterone and Cortisol in Man

Cited by 3 publications

References 0 publications

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol‐17β levels in zebrafish early life stages

Effects of two different anaesthetics on serum concentrations of cortisol and luteinizing hormone in barrows and gilts

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