Effects of Myrtus communis extract treatment in bile duct ligated rats

Şen, Ali; Özkan, Sevil; Recebova, Kafiye; Çevik, Özge; Ercan, Feríha; Demirci, Elif; Bitiş, Leyla; Şener, Göksel

doi:10.1016/j.jss.2016.06.094

Cited by 20 publications

(22 citation statements)

References 53 publications

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“…Increased lipid peroxidation in bile or pancreas tissue have been reported in humans with AP (Park et al, 2003). On the contrary, similar to previous reports (Escobar et al, 2009;Sen et al, 2016Sen et al, , 2017, the study results showed that MC treatment exerted a notable reduction in lipid peroxidation and an increase in GSH levels. The model verifies tissue damage, not only histologically but also biochemically, with GSH depletion and MDA elevation.…”

Section: Discussionsupporting

confidence: 87%

“…Previous clinical (Gullo et al, 1996;Warshaw & O'Hara, 1978) and experimental animal studies (Ceranowicz et al, 2015;Dembiński et al, 2001;Vollmar & Menger, 2003;Waldner, 1992) pro-inflammatory cytokines (Gress, Arnold, & Adler, 1990;Kusterer, Enghofer, Zendler, Blochle, & Usadel, 1991;Tomkötter et al, 2016;Vollmar & Menger, 2003). The increase in MPO activity shows widespread inflammation in many inflammation models, including AP (Gurler et al, 2019;Ozgul et al, 2019;Sen et al, 2016). It is well-known that leukocyte recruitment within the inflamed pancreas begins in the early phase of AP (Escobar et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…In light of this knowledge, the inflammatory status of pancreatic tissues through MPO activity and cytokines has been investigated. MC treatment may decrease MPO activity in colonic and liver tissues (Sen et al, 2016(Sen et al, , 2017 Acute pancreatitis causes an important increase in the tissue IL-1β The increase in MPO activity shows widespread inflammation in many inflammation models, including AP (Gurler et al, 2019;Ozgul et al, 2019;Sen et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…F I G U R E 1 Experimental protocol of rats (Sen et al, 2016(Sen et al, , 2017. Six hours after the final injection of cerulein, blood samples were taken by cardiac puncture under sodium pentobarbital anesthesia (40 mg/kg/ip).…”

Section: Experimental Designmentioning

confidence: 99%

“…and digestive system disorders (Aykac et al, 2019;Hennia, Miguel, & Nemmiche, 2018;Jabri, Marzouki, & Sebai, 2018). Antioxidants or the anti-inflammatory properties of M. communis leaves have been reported in previous experimental studies, such as liver fibrosis (Sen et al, 2016), ear edema and granuloma (Maxia, Frau, Falconieri, Karchuli, & Kasture, 2011), mouse paw edema (Rossi et al, 2009), pulmonary fibrosis (Samareh-Fekri et al, 2018), and colonic inflammation in rats (Sen et al, 2017). Nevertheless, the effect of M. communis subsp.…”

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confidence: 98%

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Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

et al. 2019

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In this study, the aim was to examine the potential protective effects of Myrtus communis subsp. communis leaf ethanol extract (MC) treatment against acute pancreatitis (AP) in rats. Thirty‐two rats were grouped as the saline‐pretreated control (C), MC‐pretreated control (MC), saline‐pretreated AP (AP), and MC‐pretreated AP (MC + AP) groups. To induce AP, cerulein was administered (50 µg/kg) two times. The rats were given MC for 14 days before cerulein injection. Six hours after the final cerulein injection, the rats were sacrificed. Pancreatic damage was associated with an increase in the serum activity of lipase and amylase, the pancreatic activity of myeloperoxidase, and the pancreatic level of malondialdehyde, interleukin‐1β, and interleukin‐6. AP also led to a decrease in the pancreatic level of anti‐inflammatory interleukin‐10 and glutathione. Pretreatment with MC before the induction of AP significantly reduced the pancreatic damage observed during the histological examination as well as reversed the biochemical changes evoked by AP. Practical applications Acute pancreatitis is characterized by high mortality (average about 5%; severe cases may reach about 30%). The current treatment for acute pancreatitis is mainly symptomatic. The introduction of herbal drugs may lead to the development of a new strategy in the treatment of this disease. This study revealed that MC reduced pancreatic injury by decreasing pro‐inflammatory cytokines, increasing antioxidant capacity and anti‐inflammatory cytokine, IL‐10. To the authors’ knowledge, this research is the first report showing that MC inhibits the development of AP. This observation suggests that MC may be useful in the prevention and the treatment of AP in clinical settings.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Experimental Designmentioning

confidence: 99%

mentioning

confidence: 98%

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Myrtus communisleaf extract protects against cerulein‐induced acute pancreatitis in rats

et al. 2019

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The therapeutic value of Myrtus communis L.: an updated review

Al-Snafi,

Teibo,

Shaheen

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Myrtus communis L. (Family: Myrtaceae) is naturally found in the western part of Asia, Southern Europe, and North Africa. It has been reportedly applied in pharmaceutical industry, traditional medicine, cosmetics, spices, and food. Pubmed, Google scholar, Web of Science, and Scopus were utilized to seek out relevant content concerning the therapeutic potential of M. communis. Subsequently, we conducted a review to identity noteworthy updates pertaining to M. communis. Myrtle berries, leaves, seeds, and essential oils are natural sources of several nutrients and bioactive compounds with marked health effects. The chemical analysis showed that M. communis contained oils, alkaloids, flavonoids, phenolics, coumarins, saponosides, tannins, quinines, and anthraquinones. A pharmacological investigation revealed that M. communis possessed anti-inflammatory, analgesic, antimicrobial, antiparasitic, antioxidant, antidiabetic, anticancer, antimutagenic, immunomodulatory, dermatological, cardiovascular, central nervous system, and gastrointestinal protective effects, among numerous other biological effects. This current review focused on the biochemical, pharmacological, therapeutic effects, and various biological activities of different parts of M. communis. It signifies that M. communis is a therapeutic plant with numerous applications in medicine and could be used as a drug isolate based on its safety and effectiveness.

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