Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells

Wu, Wei; Abraham, Linu; Ogony, Joshua; Matthews, Richard H.; Goldstein, Glenn; Erçal, Nuran

doi:10.1016/j.lfs.2008.03.016

Cited by 53 publications

(40 citation statements)

References 53 publications

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“…On the other hand, various thiol antioxidants and GSH precursors such as cysteine, N-acetylcysteine, N-acetylcysteine amide (NACA), and cysteamine have been shown to protect rodents against the harmful effects of radiation. Their application, however, has been limited by their toxic side-effects [13,102].…”

Section: The Role Of Probiotics and Prebiotics In Intestinal Antioxidmentioning

confidence: 99%

“…Various chemical compounds such as antioxidants and free-radical scavengers have been investigated as potential radioprotective agents. However, the inherent toxicity of these agents at the radioprotective doses warranted further search for safer and more effective radioprotectors [12,13]. Accumulating evidence suggests that probiotics and prebiotics represent promising candidates for the prevention and control of several gastrointestinal disorders [14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

et al. 2010

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Radiation therapy has become one of the most important treatment modalities for human malignancy, but certain immediate and delayed side-effects on the normal surrounding tissues limit the amount of effective radiation that can be administered. After exposure of the abdominal region to ionizing radiation, nearly all patients experience transient symptoms of irradiation of the bowel. Acute-phase symptoms may persist for a short time, yet long-term complications can represent significant clinical conditions with high morbidity. Data from both experimental studies and clinical trials suggest the potential benefit for probiotics in radiation-induced enteritis and colitis. On the other hand, it is well evidenced that both useful and harmful effects of therapeutic applications of ionizing radiation upon living systems are ascribed to free-radical production. Therefore, the hypothesis that probiotics reinforce antioxidant defense systems of normal mucosal cells exposed to ionizing radiation may explain to an extent their beneficial action. The aim of this review is threefold: First, to make a short brief into the natural history of radiation injury to the intestinal tract. Second, to describe the primary interaction of ionizing radiation at the cellular level and demonstrate the participation of free radicals in the mechanisms of injury and, third, to try a more profound investigation into the antioxidant abilities of probiotics and prebiotics based on the available experimental and clinical data.

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Section: The Role Of Probiotics and Prebiotics In Intestinal Antioxidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

et al. 2010

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“…NAC, CAT and DPI, GAs-induced generation of ROS was attenuated. NAC is a thio-containing antioxidant capable of directly inactivating ROS as well as inducing GSH production [34]. CAT is an enzyme involved in the conversion H 2 O 2 to H 2 O [35].…”

Section: Discussionmentioning

confidence: 99%

Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system

Liu

Liang

et al. 2015

Chemico-Biological Interactions

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“…44,45 The ra di op ro tec ti ve ef fects of NAC on coch le ar cells and ovary cells were at tri bu ted to a mec ha nism ope ra ting over the thiol path way. 46,47 NAC tre at ment ma in ta i ned the in tes ti nal mu co sal bar ri er in teg rity af ter burn in jury and had a ra di op ro tec ti ve ef fect on li ver tis su e. 32,48,49 E-cad he rin is one of the ma jor cad he rins in the intes ti nal epit he li um and an al te ra ti on of its ex pres sion has be en ob ser ved in a num ber of diserders in vol ving loss of cell po la ri za ti ons and dif fe ren ti a tion. 50 The ex pres si on of pan cad he rin in the in tes ti nal epit he li um in NAC tre at ment was in cre a sed.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Evaluation of the Protective Effect of Ginkgo Biloba, Probiotic Saccharomyces Boulardii and N-Acetylcysteine on Radiation-Induced Small Intestine Injury

Filiz¹,

Gürsel²,

Biyiksiz³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : The aim of this study was to de mons tra te the ra di op ro tec ti ve ef fects of gink go bi lo ba (G. bi lo ba, EGb 761), pro bi o tic Sacc ha romy ces bo u lar di i (S. bo u lar di i) and N-acetylc yste i ne (NAC) on ra di ati on-in du ced small in tes ti ne in jury vi a im mu no his toc he mi cal eva lu a ti on using pan cad he rin, a cell ad he si on mo le cu le. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : A to tal of 48 fe ma le Wis tar al bi no rats we re di vi ded in to fi ve gro ups: ne gati ve and po si ti ve con trols, G. bi lo ba, S. Bo u lar di i and NAC gro ups. The ra di op ro tec ti ve agents we re star ted as twi ce per day by ga va ge re gi men the day be fo re the first ra di a ti on ex po su re. Ex ter nal ab do mi nal ra di ot he rapy, 5Gy/day, un der ge ne ral anest he si a was ad mi nis te red on fi ve con se cu ti ve days en ding up with fi ve frac ti ons in total (25Gy). Ra di op ro tec ti ve agent ad mi nis tra ti on was comp le ted to 14 days and the rats we re sac ri fi ced on the 15 th day. Af ter ex trac ti on of the je ju num, tis su e morp ho logy, in teg rity and the num ber of vil li were eva lu a ted in H&E sta i ned sli des and pan cad he rin im mu no re ac ti ve cells we re eva lu a ted im mu no his toc he mi cally. R Re e s su ul lt ts s: : The dis rup ti on of mu co sal morp ho lo gi cal in teg rity, de ge ne ra ti ve spa ces and ede ma to us ca vi ti es were ob ser ved af ter ra di a ti on-in du ced je ju num in jury. The con tri bu ti on of the ra di op ro tec ti ve ef fect of all agents were shown on tis su e in teg rity. Ho we ver, the most pro mi nent ef fect was no ted in the NAC gro up. In addition, the num bers of vil li and pan cad he rin im mu no re ac ti ve cells in the NAC gro up we re sig ni fi cantly higher than the ot her gro ups. C Co on nc c l lu u s si i o on n: : NAC is a go od agent in pro tec ting aga inst and ame li o ra ting ad ver se ef fects of ra di ot he rapy in a rat mo del.K Ke ey y W Wo or rd ds s: : Ra di ot he rapy; in tes ti ne, small; ra di a ti on-pro tec ti ve agents; cad he rins; im mu no his toc he mistry Ö ÖZ ZE ET T A Am ma aç ç: : Bu ça lış ma da, rad yas yo na bağ lı in ce bağırsak ha sa rın da Gink go bi lo ba (EGb 761), pro bi yo tik Sacc ha romy ces bo u lar di i ve N-ase til sis te in (NAC)'in rad yop ro tek tif et ki le ri ni bir hüc re ad hez yon mo le kü lü olan pan ka de rin ile im mu no his to kim ya sal ola rak or ta ya koy mak amaç lan mış tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Toplam 48 di şi Wis tar al bi no sı ça nı ne ga tif ve po zi tif kon trol gru bu, G. bi lo ba, S. Bo u lar di i ve NAC gru bu ol mak üze re beş gru ba ay rıl mış tır. Rad yop ro tek tif ajan lar, rad yas yon uy gu la ma sın dan bir gün ön ce son da ile gün -de iki kez uy gu lan ma ya baş la mış tır. Eks ter nal ab do mi nal rad yo te ra pi ge nel anes te zi al tın da 5Gy/gün do zundan beş gün sü re ile uy gu lan mış tır (25Gy). Rad yop ro tek tif a...

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Effects of N-acetylcysteine amide (NACA), a thiol antioxidant on radiation-induced cytotoxicity in Chinese hamster ovary cells

Cited by 53 publications

References 53 publications

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

Antioxidant Properties of Probiotics and Their Protective Effects in the Pathogenesis of Radiation-Induced Enteritis and Colitis

Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system

Immunohistochemical Evaluation of the Protective Effect of Ginkgo Biloba, Probiotic Saccharomyces Boulardii and N-Acetylcysteine on Radiation-Induced Small Intestine Injury

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