Effects of Naltrexone on Alcohol Self‐Administration in Heavy Drinkers

Davidson, Dena; Palfai, Tibor P.; Bird, C. G.; Swift, Robert M.

doi:10.1111/j.1530-0277.1999.tb04099.x

Cited by 156 publications

(76 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Four different SA paradigms were represented, the most common (5 studies) being a paradigm involving administration of ‘mini‐drinks’ (target blood alcohol concentration increment .015 g/dl per drink), first published by O'Malley et al (2002). Other paradigms were reported by (Davidson et al ., 1996; 1999, Kruse et al ., 2012) and de Wit et al . (1999).…”

Section: Resultsmentioning

confidence: 99%

Effects of naltrexone on alcohol self‐administration and craving: meta‐analysis of human laboratory studies

et al. 2016

View full text Add to dashboard Cite

Randomized clinical trials have established the efficacy of naltrexone for reducing quantity of alcohol consumption and incidence of relapse to heavy drinking. To evaluate putative treatment mechanisms, human laboratory studies have examined naltrexone's effects on alcohol responses and self‐administration during short‐term medication protocols. Results from these studies are inconsistent and have yet to be examined in aggregate. This meta‐analysis aimed to quantify naltrexone's effects on alcohol self‐administration and craving in the context of placebo‐controlled human laboratory trials. Potential moderators of medication effects were also examined. Meta‐analyses of alcohol self‐administration (k = 9, N = 490) and craving (k = 16, N = 748) confirmed that, under controlled experimental conditions, naltrexone reduces the quantity of consumption (Hedges' g = −.277, SE = .074, 95 percent CI = −.421, −.133, p < .001) and magnitude of self‐reported craving (g = −.286, SE = .066, 95 percent CI = −.416, −.156, p < .001) relative to placebo. Subgroup and moderation analyses found no evidence that effect sizes differed by study population (dependent versus non‐dependent drinkers), laboratory paradigm or duration of medication exposure. These results substantiate prior evidence for reductions in event‐level craving and consumption as potential treatment mediators, also establishing effect sizes to inform future human laboratory trials. From a clinical perspective, these results may provide additional evidence regarding naltrexone's efficacy in the context of acute or subacute dosing regimens.

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of naltrexone on alcohol self‐administration and craving: meta‐analysis of human laboratory studies

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The ability to elicit a broad range of responses is a key feature of prior self-administration models (McKee et al, 2006; O’Malley, Krishnan-Sarin, Farren, Sinha, & Kreek, 2002), as such variability is necessary to observe effects of experimental manipulations or interventions on self-administration behavior in future studies. To enhance ecological validity, all self-administration sessions were conducted in an actual bar (Davidson, Swift, & Fritz, 1996; Davidson, Palfai, Bird, & Swift, 1999). Consistent with prior alcohol administration studies involving young adults (e.g., Corbin, Gearhardt, & Fromme, 2008; Sayette et al, 2012), sessions were conducted in groups of 2–4 participants to account for social factors that are critical to young adult drinking behavior (Sayette et al, 2012; Wood, Read, Palfai, & Stevenson, 2001).…”

mentioning

confidence: 99%

A human alcohol self-administration paradigm to model individual differences in impaired control over alcohol use.

Leeman¹,

Corbin²,

Nogueira³

et al. 2013

Experimental and Clinical Psychopharmacology

View full text Add to dashboard Cite

We developed an alcohol self-administration paradigm to model individual differences in impaired control. The paradigm includes moderate drinking guidelines meant to model limits on alcohol consumption, which are typically exceeded by people with impaired control. Possible payment reductions provided a disincentive for excessive drinking. Alcohol use above the guideline, despite possible pay reductions, was considered to be indicative of impaired control. Heavy-drinking 21–25 year-olds (N = 39) were randomized to an experimental condition including the elements of the impaired control paradigm or to a free-drinking condition without these elements. Alcohol self-administration was compared between these two conditions to establish the internal validity of the experimental paradigm. In both conditions, participants self-administered beer and non-alcoholic beverages for 3 hours in a bar setting with 1–3 other participants. Experimental condition participants self-administered significantly fewer beers and drank to lower blood-alcohol concentrations (BACs) on average than those in the free-drinking condition. Experimental condition participants were more likely than free-drinking condition participants to intersperse non-alcoholic beverages with beer and to drink at a slower pace. Although experimental condition participants drank more moderately than those in the free-drinking condition overall, their range of drinking was considerable (BAC range = .024–.097) with several participants drinking excessively. A lower initial subjective response to alcohol and earlier age of alcohol use onset were associated with greater alcohol self-administration in the experimental condition. Given the variability in response, the impaired control laboratory paradigm may have utility for preliminary tests of novel interventions in future studies and for identifying individual differences in problem-drinking risk.

show abstract

“…Booth et al (1992a) also reported alpha coefficients ranging from 0.52–0.85 for the 6 SPS subscales and an alpha of 0.86 for the Total score. The Positive and Negative Affect Schedule (PANAS; Watson, Clark, & Tellegen, 1988) was used by Davidson et al (Davidson, Palfai, Bird, & Swift, 1999) to assess positive mood in alcoholic patients. They found that positive mood was significantly lower when research participants were medicated with naltrexone as compared to placebo.…”

mentioning

confidence: 99%

Measurement of mental health in substance use disorder outpatients

Alterman

Cacciola

Dugosh

et al. 2010

Journal of Substance Abuse Treatment

View full text Add to dashboard Cite

Few studies have examined mental health (MH) attributes of substance use disorder (SUD) patients. The present study examines the internal consistency, concurrent validity, and comparative level of MH attributes (i.e., optimism, life attitudes, spirituality/religiousness, social support, positive mood, hope, and vitality) in SUD patients compared to the instrument development group. The internal consistency of optimism, spirituality/religiousness, positive mood, hope, and vitality were similar in both groups. Some subscales of the social support and life attitude measures had lower internal consistency than was found for the original samples, although internal consistency of more global constructs were comparable. SUD patients had higher positive mood, spirituality/religiousness, and hope scores, while social support, life attitudes, and optimism scores were lower than in the original sample. Correlations between MH attributes and recent life problems of SUD patients generally supported the concurrent validity of the MH measures. Keywords Mental health measurement; SUD patients; psychometric propertiesPositive psychology is a greatly expanding field with increased numbers of positive attributes being considered, delineated, and researched (Lopez & Snyder, 2009). There is currently no fully agreed upon conceptual framework to describe the various dimensions of mental health (MH). One system that has begun to gain support was formulated by Keyes (2005Keyes ( , 2007 and includes three primary dimensions -emotional, psychological, and social. Keyes (2005Keyes ( , 2007Keyes ( , 2009 has argued that MH is a distinctive dimension from mental illness (MI) and in a confirmatory factor analyses (CFA) of MH and MI (Keyes, 2005) measures found them to be relatively independent dimensions. A recent study by our group (Alterman, Cacciola, Ivey, Coviello, Lynch, Dugosh, & Habing, submitted paper) in outpatients with substance use disorders (SUD), using both exploratory factor analysis (EFA) and CFA, obtained findings consistent with this conclusion. Importantly, literature has shown that MH attributes such as © 2010 Elsevier Inc. All rights reserved Corresponding author. Ph: 610 356 4955; Fax = 215 399 0987; Alterman@mail.trc.upenn.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In the current study we assessed a number of attributes of MH in a relatively large group of inner city SUD outpatients shortly after their intake to treatment. These attributes included the 4 just described (i.e., optimism, life attitudes, social support, and positive mood), and 3 others -spiritual...

show abstract

Effects of Naltrexone on Alcohol Self‐Administration in Heavy Drinkers

Cited by 156 publications

References 20 publications

Effects of naltrexone on alcohol self‐administration and craving: meta‐analysis of human laboratory studies

Effects of naltrexone on alcohol self‐administration and craving: meta‐analysis of human laboratory studies

A human alcohol self-administration paradigm to model individual differences in impaired control over alcohol use.

Measurement of mental health in substance use disorder outpatients

Contact Info

Product

Resources

About