Effects of Opium Addiction on Some Biochemical Parameters in Diabetic Rats

Ahmed, Hatem Abdel Moniem; Ahmed, Shaaban; Gawish, Esraa M; Alanwar, Alaa; Ibrahem, M. A.

doi:10.9734/ijbcrr/2016/23301

Cited by 4 publications

(3 citation statements)

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“…The results of a basic study indicated that the administration of opium decreased the serum levels of AST, ALT, total protein, total cholesterol, and TG while also resulting in an increase in urea and creatinine in diabetic rats [ 33 ]. The results of the PERSIAN cohort study revealed a positive correlation between opium consumption and lower levels of cholesterol and LDL.…”

Section: Discussionmentioning

confidence: 99%

Which risk factor best predicts coronary artery disease using artificial neural network method?

Azdaki,

Salmani,

Kazemi

et al. 2024

BMC Med Inform Decis Mak

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Background Coronary artery disease (CAD) is recognized as the leading cause of death worldwide. This study analyses CAD risk factors using an artificial neural network (ANN) to predict CAD. Methods The research data were obtained from a multi-center study, namely the Iran-premature coronary artery disease (I-PAD). The current study used the medical records of 415 patients with CAD hospitalized in Razi Hospital, Birjand, Iran, between May 2016 and June 2019. A total of 43 variables that affect CAD were selected, and the relevant data was extracted. Once the data were cleaned and normalized, they were imported into SPSS (V26) for analysis. The present study used the ANN technique. Results The study revealed that 48% of the study population had a history of CAD, including 9.4% with premature CAD and 38.8% with CAD. The variables of age, sex, occupation, smoking, opium use, pesticide exposure, anxiety, sexual activity, and high fasting blood sugar were found to be significantly different among the three groups of CAD, premature CAD, and non-CAD individuals. The neural network achieved success with five hidden fitted layers and an accuracy of 81% in non-CAD diagnosis, 79% in premature diagnosis, and 78% in CAD diagnosis. Anxiety, acceptance, eduction and gender were the four most important factors in the ANN model. Conclusions The current study shows that anxiety is a high-prevalence risk factor for CAD in the hospitalized population. There is a need to implement measures to increase awareness about the psychological factors that can be managed in individuals at high risk for future CAD.

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Section: Discussionmentioning

confidence: 99%

Which risk factor best predicts coronary artery disease using artificial neural network method?

Azdaki,

Salmani,

Kazemi

et al. 2024

BMC Med Inform Decis Mak

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show abstract

“…Although opium increased serum insulin and decreased serum glucose, the effect was not significant; this was due to metabolic disorders in diabetic animals. In addition, it is suggested that opium consumption in diabetic patient is not useful [ 137 ]. Similarly, Sadeghian et al [ 138 ] reported the effects of available opium substance on glucose and lipid metabolism in streptozotocin-induced-diabetic rats by testing opium contained in the juice of the seed capsule of the P. somnniferum .…”

Section: Biological Activities Of the Papaver Genusmentioning

confidence: 99%

Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications

Butnariu

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium poppy) is the most important species in supplying phytochemicals for the formulation of drugs, mainly alkaloids like morphine, codeine, rhoeadine, thebaine, and papaverine. In addition, Papaver plants present other types of phytochemicals, which altogether are responsible for its biological activities. Therefore, this review covers the phytochemical composition of Papaver plants, including alkaloids, phenolic compounds, and essential oils. The traditional uses are reviewed along with their pharmacological activities. Moreover, safety aspects are reported to provide a deep overview of the pharmacology potential of this genus. An updated search was carried out in databases such as Google Scholar, ScienceDirect, and PubMed to retrieve the information. Overall, this genus is a rich source of alkaloids of different types and also contains interesting phenolic compounds, such as anthocyanins, flavonols, and the characteristic indole derivatives nudicaulins. Among other pharmacological properties, numerous preclinical studies have been published about the analgesic, anticancer, antimicrobial, antioxidant, and antidiabetic activities of Papaver plants. Although it highlights the significant impact of this genus for the treatment of a variety of diseases and conditions, as a future prospect, characterization works accompanying preclinical studies are required along with clinical and toxicology studies to establish a correlation between the scientific and traditional knowledge.

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“…Considered as one of the major threats to human life, coronary artery disease (CAD) has placed a great social, medical and economic burden on society 1‐3 . Also, a complex and multifactorial disease, CAD is characterised by a variety of factors including hypertension, obesity, glucose intolerance and dyslipidaemias, the last of which is the major risk factor for atherosclerotic CAD 3‐6 .…”

Section: Introductionmentioning

confidence: 99%

Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta‐analysis of randomised clinical trials

Kheirmandparizi

Keshavarz

Nowrouzi-Sohrabi

et al. 2021

Int J Clinical Practice

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This meta‐analysis was conducted to evaluate the effects of garlic extract on total cholesterol (TC), triglycerides (TG), low‐density lipoprotein‐cholesterol (LDL‐c) and high‐density lipoprotein‐cholesterol (HDL‐c), among the patients with coronary artery disease (CAD). Literature searches were conducted in EMBASE, Scopus, PubMed, Web of Science and Cochrane Library until Sep18th, 2020. Inter‐study heterogeneity was examined using Cochrane's Q and I2 tests. The random‐effect models were utilised to pool the weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Six articles were enrolled in the current meta‐analysis. Garlic consumption significantly reduced TC levels (WMD −16.32 mg/dL; 95% CI −31.22, −1.43; P = .032). We found no significant effects on TG (WMD −10.93 mg/dL; 95% CI −26.19, 4.32; P = .160), HDL‐c (WMD 4.55 mg/dL; 95% CI −1.13, 10.23; P = .116) and LDL‐c concentrations (WMD −3.65 mg/dL; 95% CI −13.21, 5.92; P = .455). Significant heterogeneity was observed for HDL‐c (I2 = 76.8%). However, the findings of sensitivity analysis revealed that upon exclusion of the potential heterogeneity source, the pooled WMD on HDL‐c levels were stable. Garlic supplementation may result in a decrease in TC, but will not affect TG, HDL‐c and LDL‐c levels among CAD patients.

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Effects of Opium Addiction on Some Biochemical Parameters in Diabetic Rats

Cited by 4 publications

References 0 publications

Which risk factor best predicts coronary artery disease using artificial neural network method?

Which risk factor best predicts coronary artery disease using artificial neural network method?

Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications

Effects of garlic extract on lipid profile in patients with coronary artery disease: A systematic review and meta‐analysis of randomised clinical trials

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