Effects of Organic Copper on Growth Performance and Oxidative Stress in Mice

Zhi, Mingyu; Tang, Ping; Liu, Ying; Zheng, Shaojiang

doi:10.1007/s12011-019-01796-2

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…An overview of the Cu benefits in livestock is presented in Table . Different forms of Cu additives have obvious effects on accelerating the growth and development of livestock, especially for piglets . It has been demonstrated that Cu can stimulate the synthesis and secretion of growth hormone. , Also, Cu increases the activity of digestive and antioxidant enzymes such as pepsin, trypsin, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in the gastrointestinal tract of piglets, thus enhancing the digestibility and free radical scavenging ability. − In addition, high dietary Cu (125 mg/kg) appears to excite the hunger center and inhibit the satiety center in the hypothalamus, thus enhancing the insulin and ghrelin secretion and salivation to stimulate appetite .…”

Section: Copper and Livestockmentioning

confidence: 99%

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Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Zhen

Chen

et al. 2022

J. Agric. Food Chem.

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The extensive use of high-concentration copper (Cu) in feed additives, fertilizers, pesticides, and nanoparticles (NPs) inevitably causes significant pollution in the ecological environment. This type of chain pollution begins with animal husbandry: first, Cu accumulation in animals poisons them; second, high Cu enters the soil and water sources with the feces and urine to cause toxicity, which may further lead to crop and plant pollution; third, this process ultimately endangers human health through consumption of livestock products, aquatic foods, plants, and even drinking water. High Cu potentially alters the antibiotic resistance of soil and water sources and further aggravates human disease risks. Thus, it is necessary to formulate reasonable Cu emission regulations because the benefits of Cu for livestock and plants cannot be ignored. The present review evaluates the potential hazards and benefits of high Cu in livestock, the environment, the plant industry, and human health. We also discuss aspects related to bacterial and fungal resistance and homeostasis and perspectives on the application of Cu−NPs and microbial high-Cu removal technology to reduce the spread of toxicity risks to humans.

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Section: Copper and Livestockmentioning

confidence: 99%

“…27 An overview of the Cu benefits in livestock is presented in Table 1. Different forms of Cu additives have obvious effects on accelerating the growth and development of livestock, 28 especially for piglets. 4 It has been demonstrated that Cu can stimulate the synthesis and secretion of growth hormone.…”

Section: Copper and Livestockmentioning

confidence: 99%

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Zhen

Chen

et al. 2022

J. Agric. Food Chem.

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“…The major source of copper is food for humans, and the absorption and toxicity of copper in various food seem different. Organic copper has higher bioavailability and lower toxicity than inorganic copper (Liu et al., 2019 ; Vieira et al., 2020 ; Zhi et al., 2020 ). The protein source had a significant effect on copper bioavailability in rainbow trout; those fed diet with soy and corn proteins require lower copper than those fed menhaden and blood proteins (Read et al., 2014 ).…”

Section: Introductionmentioning

confidence: 99%

The influence of gastrointestinal pH on speciation of copper in simulated digestive juice

Zhi

et al. 2021

Food Science & Nutrition

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“…It has been demonstrated through several studies that copper can accelerate the growth and development of livestock ( Zhi et al, 2020 ), including broilers ( Ewing et al, 1998 ), goats ( Solaiman et al, 2001 ), and rabbits ( Skrivanova et al, 2001 ). This trace mineral improves growth and feed conversion rates of piglets, thus enhancing production performance ( Stahly et al, 1980 ; Apgar et al, 1995 ).…”

Section: Introductionmentioning

confidence: 99%

Biosorption of Copper in Swine Manure Using Aspergillus and Yeast: Characterization and Its Microbial Diversity Study

Zhen

Wang

et al. 2021

Front. Microbiol.

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Dietary copper supplementation in the feed of piglets generally exceeds 250–800 mg/kg, where a higher quantity (>250 mg/kg) can promote growth and improve feed conversion. Despite the reported positive effects, 90% of copper is excreted and can accumulate and pollute the soil. Data indicate that fungi have a biosorptive capacity for copper. Thus, the objectives of the present experiment were to study the effects of adding different strains of fungi on the biosorptive capacity for copper in swine manure and to evaluate potential effects on microbiota profiles. Aspergillus niger (AN), Aspergillus oryzae (AO), and Saccharomyces cerevisiae (SC) were selected, and each added 0.4% into swine manure, which contain 250 mg/kg of copper. The incubations lasted for 29 days, and biosorption parameters were analyzed on the 8th (D8), 15th (D15), 22nd (D22), and 29th (D29) day. Results showed that after biosorption, temperature was 18.47–18.77°C; pH was 6.33–6.91; and content of aflatoxin B1, ochratoxin A, and deoxynivalenol were low. In addition, residual copper concentration with AN was the lowest on D15, D22, and D29. The copper biosorption rate was also highest with AN, averaging 84.85% on D29. Biosorption values for AO reached 81.12% and for SC were lower than 80%. Illumina sequencing of 16S and ITS rRNA gene revealed that fungal treatments reduced the diversity and richness of fungal abundance, but had no effect on bacterial abundance. Unknown_Marinilabiliaceae, Proteiniphilum, Tissierella, and Curvibacter were the dominant bacteria, while Aspergillus and Trichoderma were the dominant fungi. However, the added strain of S. cerevisiae was observed to be lower than the dominant fungi, which contained less than 0.05%. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment predicted via PICRUSt2 that there were bacterial genes potentially related to various aspects of metabolism and environmental information processing. Overall, data indicated that Aspergillus can provide microbial materials for adsorption of copper.

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Effects of Organic Copper on Growth Performance and Oxidative Stress in Mice

Cited by 6 publications

References 35 publications

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

Latent Benefits and Toxicity Risks Transmission Chain of High Dietary Copper along the Livestock–Environment–Plant–Human Health Axis and Microbial Homeostasis: A Review

The influence of gastrointestinal pH on speciation of copper in simulated digestive juice

Biosorption of Copper in Swine Manure Using Aspergillus and Yeast: Characterization and Its Microbial Diversity Study

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