Effects of Ozonated Olive Oil on Acute Radiation Proctitis in Rats

Gültekin, Fatma Ayça; Bakkal, Bekir Hakan; Sümer, Demet; Köktürk, Fürüzan; Bektaş, Sibel

doi:10.5152/balkanmedj.2013.9158

Cited by 19 publications

(18 citation statements)

References 28 publications

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“…The ozonated-oil does not penetrate through the mucous membranes but, instead, reacts with PUFA to induce cellular production of hydrogen peroxide and alkenals which act as second messengers in improving wound healing [ 38 , 39 ]. The beneficial effect of ozonated-oil in radiation proctitis is currently supported by a preclinical study where ozonated-oil decreased macroscopic and pathological findings of acute radiation proctitis in rats [ 40 ]. These findings concur with a similar beneficial effect described in bisphosphonate-induced osteonecrosis of the jaw in cancer patients [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Clavo

Santana‐Rodríguez

Llontop

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Introduction. Persistent radiation-induced proctitis and rectal bleeding are debilitating complications with limited therapeutic options. We present our experience with ozone therapy in the management of such refractory rectal bleeding. Methods. Patients (n = 12) previously irradiated for prostate cancer with persistent or severe rectal bleeding without response to conventional treatment were enrolled to receive ozone therapy via rectal insufflations and/or topical application of ozonized-oil. Ten (83%) patients had Grade 3 or Grade 4 toxicity. Median follow-up after ozone therapy was 104 months (range: 52–119). Results. Following ozone therapy, the median grade of toxicity improved from 3 to 1 (p < 0.001) and the number of endoscopy treatments from 37 to 4 (p = 0.032). Hemoglobin levels changed from 11.1 (7–14) g/dL to 13 (10–15) g/dL, before and after ozone therapy, respectively (p = 0.008). Ozone therapy was well tolerated and no adverse effects were noted, except soft and temporary flatulence for some hours after each session. Conclusions. Ozone therapy was effective in radiation-induced rectal bleeding in prostate cancer patients without serious adverse events. It proved useful in the management of rectal bleeding and merits further evaluation.

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Section: Discussionmentioning

confidence: 99%

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Clavo

Santana‐Rodríguez

Llontop

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…Using sildenafil would be an effective approach to prevent this pathological situation whose treatment has such drawbacks [19][20][21][22][23] . Sildenafil is a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase (PDE)-5, which catalyzes the hydrolysis of cGMP and has a relaxant effect on the smooth muscle cells of the arterioles supplying the human corpus cavernosum 24 .…”

Section: ■ Discussionmentioning

confidence: 99%

Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats

Yavuz¹,

Ercan²,

Karagülle³

et al. 2018

Acta Cir. Bras.

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Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Results: Our histopathological evaluations indicated significant increases in lesion severity, cryptic apsis, cryptitis, cryptic distortion, reactive atypia and infiltration depth of the control (proctitis) group. While the prophylaxis group and the treatment group had significantly lower scores. High-dose group showed similar results as prophylaxis group. Histopathological findings of the prophylaxis group was more significant than the treatment group. Immunoreactivities of IL-1β, FGF-2, TNF-α and HIF-1α increased in the control group especially in the epithelial and cryptic regions. On the contrary, sildenafil application caused significant decreases of inflammatory markers in all treatment groups, specifically better results in the prophylaxis group. Conclusion: The sildenafil has anti-inflammatory effects on ARP, as well as protective effects against ARP and the protective effect of sildenafil surpasses its therapeutic effect histopathologically.

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“…Ozonated oils are of great interest in pharmaceutical and cosmetic areas due to their antibacterial, fungicide and antiprotozoal properties. 1,2 The ozonization of vegetal oils under diverse conditions have been studied for the treatment of skin infections such as dermatitis, acne, ulcers, wounds, and burns, the treatment of asthma, as a laxative, the treatment of intestinal infections, and gastroduodenal ulcers, and healing infections caused by Giardia lamblia. 3,4 The pharmacological activity of ozonated oils is dependent on the level of ozonation and the composition of the oil.…”

Section: Introductionmentioning

confidence: 99%

“…[9][10][11] According to Pinto and Lanças (2010) 12 the predominant composition of neem oil fatty acids is of oleic acid (41.09%), stearic (20.61%), palmitic (20.18%) and linoleic (14.08%), being the unsaturated sensitive to structural chemical transformation by usual oxidative processes like the ozonolysis. 13,14 Ozonolysis occurs by the addition of ozone (1) to unsaturated fatty acids (2) to form the malozonide (3), which is unstable and decomposes to zwitterion (4) and an aldehyde (5). Compounds 4 and 5 react with each other by cycloaddition to render the ozonides (6) and aldehydes.…”

Section: Introductionmentioning

confidence: 99%

Ozonolysis of neem oil: preparation and characterization of potent antibacterial agents against multidrug resistant bacterial strains

et al. 2017

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Effects of Ozonated Olive Oil on Acute Radiation Proctitis in Rats

Cited by 19 publications

References 28 publications

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Ozone Therapy in the Management of Persistent Radiation-Induced Rectal Bleeding in Prostate Cancer Patients

Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats

Ozonolysis of neem oil: preparation and characterization of potent antibacterial agents against multidrug resistant bacterial strains

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