Effects of Phytosterol Ester on the Fatty Acid Profiles in Rats with Nonalcoholic Fatty Liver Disease

Liu, Song; Zhou, Haiyue; Yu, Wenjuan; XianBin, Ding; Yang, Li; Wu, Jiayi; Song, Chenwei

doi:10.1089/jmf.2019.4468

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…Glucocorticoids, a kind of steroid hormones, are responsible for diverse metabolic functions and driving the NAFLD [64] . In addition, unsaturated fatty acids levels are closely associated with hepatic steatosis [65] . Therefore, the bile acids, steroid hormones, and unsaturated fatty acids alterations by PFOA treatment likely contributed to the observed liver damage.…”

Section: Resultsmentioning

confidence: 99%

Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity

Guo

Lin

et al. 2022

Journal of Advanced Research

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Section: Resultsmentioning

confidence: 99%

Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity

Guo

Lin

et al. 2022

Journal of Advanced Research

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“…Our previous animal experiments revealed that phytosterol ester (PSE) intervention attenuates hepatic steatosis by regulating the expression of transforming growth factor-β1 (TGF-β1), TGF-β2, tumour necrosis factor-α (TNF-α), uncoupling protein 2 (UCP-2), peroxisome proliferator-activated receptor-α (PPAR-α) and PPAR-γ in hepatic tissue at both the mRNA and protein levels and regulates the fatty acid metabolic profile and gut microbiota dysbiosis in NAFLD rats. [17][18][19] Moreover, plant-and food-derived sterols possess antioxidant, metabolism-regulating, and anti-inflammatory activities. Therefore, sterols appear to be a feasible option for combination with n-3 PUFAs, 20 which may be applied for the prevention and treatment of chronic metabolic-related liver diseases and cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Changes in the serum metabolomic profiles of subjects with NAFLD in response to n-3 PUFAs and phytosterol ester: a double-blind randomized controlled trial

XianBin

Xu²,

Nie

et al. 2022

Food Funct.

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“…A previous study [ 8 ] evaluated the antioxidant potential of

-Sitosterol in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis. There was another study that suggested that phytosterol esters have [ 9 ] effects on countering hypercholesterolemia-related changes in the brain by decreasing the cholesterol levels, increasing the phospholipid levels, and increasing the level of antioxidant enzymes.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats

Sheng

Guo

et al. 2022

Molecules

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The present study was designed to examine the efficacy and protection mechanisms of sea buckthorn sterol (SBS) against acute liver injury induced by carbon tetrachloride (CCl4) in rats. Five-week-old male Sprague-Dawley (SD) rats were divided into six groups and fed with saline (Group BG), 50% CCl4 (Group MG), or bifendate 200 mg/kg (Group DDB), or treated with low-dose (Group LD), medium-dose (Group MD), or high-dose (Group HD) SBS. This study, for the first time, observed the protection of SBS against CCl4-induced liver injury in rats and its underlying mechanisms. Investigation of enzyme activities showed that SBS-fed rats exhibited a significant alleviation of inflammatory lesions, as evidenced by the decrease in cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and gamma-glutamyl transpeptidase (γ-GT). In addition, compared to the MG group, the increased indices (superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), total antioxidant capacity (T-AOC), and total protein (TP)) of lipid peroxidation and decreased malondialdehyde (MDA) in liver tissues of SBS-treated groups showed the anti-lipid peroxidation effects of SBS. Using the wide range of targeted technologies and a combination of means (UPLC-MS/MS detection platform, self-built database, and multivariate statistical analysis), the addition of SBS was found to restore the expression of metabolic pathways (e.g., L-malic acid, N-acetyl-aspartic acid, N-acetyl-l-alanine, etc.) in rats, which means that the metabolic damage induced by CCl4 was alleviated. Furthermore, transcriptomics was employed to analyze and compare gene expression levels of different groups. It showed that the expressions of genes (Cyp1a1, Noct, and TUBB6) related to liver injury were regulated by SBS. In conclusion, SBS exhibited protective effects against CCl4-induced liver injury in rats. The liver protection mechanism of SBS is probably related to the regulation of metabolic disorders, anti-lipid peroxidation, and inhibition of the inflammatory response.

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Effects of Phytosterol Ester on the Fatty Acid Profiles in Rats with Nonalcoholic Fatty Liver Disease

Cited by 10 publications

References 32 publications

Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity

Integrative omics analysis reveals the protective role of vitamin C on perfluorooctanoic acid-induced hepatoxicity

Changes in the serum metabolomic profiles of subjects with NAFLD in response to n-3 PUFAs and phytosterol ester: a double-blind randomized controlled trial

Metabolomic Profiling Reveals Protective Effects and Mechanisms of Sea Buckthorn Sterol against Carbon Tetrachloride-Induced Acute Liver Injury in Rats

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