Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring

Cannizzaro, Carla; Plescia, Fulvio; Gagliano, M.; G, Cannizzaro; Provenzano, Giuseppa; Mantia, Giacoma; Cannizzaro, Emanuele

doi:10.1016/j.neures.2007.05.012

Cited by 21 publications

(19 citation statements)

References 82 publications

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“…Compounds with high 5‐HT 1A receptor affinity are also effective in the treatment of clinical syndromes related with stress, including anxiety [Cannizzaro et al., ]. In our study, the 5‐HT 1A antagonist, WAY‐100635 and the 5‐HT 1B/1D antagonist, , did not alter the number of entries into the open arms or the time spent in the open arms.…”

Section: Discussionsupporting

confidence: 39%

“…To investigate the role of the serotonergic system in the anxiolytic-like effect of TRIM in the EPM test, we used the tryptophan hydroxylase inhibitor pCPA, which depletes 5-HIAA and 5-HT in the frontal cortex by more than 90% [Harkin et al, 2003]. Administration of pCPA for 3 days at a dose of 150 mg/kg did not affect the number of Compounds with high 5-HT 1A receptor affinity are also effective in the treatment of clinical syndromes related with stress, including anxiety [Cannizzaro et al, 2007]. In our study, the 5-HT 1A antagonist, WAY-100635 and the 5-HT 1B/1D antagonist, GR127935, did not alter the number of entries into the open arms or the time spent in the open arms.…”

Section: Discussionmentioning

confidence: 99%

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5‐HT₁ and 5‐HT₂ Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

Tanyeri

Mutlu

Ulak

et al. 2013

Drug Development Research

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Preclinical Research TRIM, a selective neuronal NOS inhibitor, had anxiolytic effects in the elevated plus‐maze (EPM) test. The aim of the present study was to evaluate the involvement of serotonergic system in the anxiolytic‐like effect of TRIM in the EPM test, a widely used animal model of anxiety. The anxiolytic‐like effect of TRIM (50 mg/kg, i.p.) in adult Wistar albino male rats in the EPM test was antagonized by pretreatment with the 5‐HT depleting agent; parachlorophenylalanine methyl ester (3 × 150 mg/kg i.p.) that inhibits 5‐HT synthesis; methiothepin (0.1 mg/kg, i.p.), a nonselective 5‐HT receptor antagonist; WAY 100635 (0.1 mg/kg i.p.), a selective 5‐HT1A receptor antagonist; GR 127935 (3 mg/kg i.p.), a selective 5‐HT1B/1D receptor antagonist; cyproheptadine (3 mg/kg i.p.), a 5‐HT2 receptor antagonist; or ketanserin (5 mg/kg i.p.), a 5‐HT2A/2C receptor antagonist. The anxiolytic‐like effects of TRIM thus appear to be mediated in part by 5‐HT1 and 5‐HT2 receptors.

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Section: Discussionsupporting

confidence: 39%

Section: Discussionmentioning

confidence: 99%

5‐HT₁ and 5‐HT₂ Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

Tanyeri

Mutlu

Ulak

et al. 2013

Drug Development Research

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“…Adult MS rats exhibit deficiency in hippocampal dependent spatial memory (Aisa et al 2009; Aisa et al 2007; Cannizzaro et al 2007; Huot et al 2002; Uysal et al 2005). We specifically used the object placement task to demonstrate longstanding baseline impairment of spatial memory in adult MS rats.…”

Section: Developmental Effects On Stress Responsiveness and Behaviormentioning

confidence: 99%

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

et al. 2012

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The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor. The adult, as well as developing brain, possess a remarkable ability to show reversible structural and functional plasticity in response to stressful and other experiences, including neuronal replacement, dendritic remodeling, and synapse turnover. This is particularly evident in the hippocampus, where all three types of structural plasticity have been recognized and investigated, using a combination of morphological, molecular, pharmacological, electrophysiological and behavioral approaches. The amygdala and the prefrontal cortex, brain regions involved in anxiety and fear, mood, cognitive function and behavioral control, also show structural plasticity. Acute and chronic stress cause an imbalance of neural circuitry subserving cognition, decision making, anxiety and mood that can increase or decrease expression of those behaviors and behavioral states. In the short term, such as for increased fearful vigilance and anxiety in a threatening environment, these changes may be adaptive; but, if the danger passes and the behavioral state persists along with the changes in neural circuitry, such maladaptation may need intervention with a combination of pharmacological and behavioral therapies, as is the case for chronic or mood anxiety disorders. We shall review cellular and molecular mechanisms, as well as recent work on individual differences in anxiety-like behavior and also developmental influences that bias how the brain responds to stressors. Finally, we suggest that such an approach needs to be extended to other brain areas that are also involved in anxiety and mood.

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“…Many investigations have demonstrated long-term spatial memory impairment in rats exposed to early life stress (Huot et al, 2002;Uysal et al, 2005;Aisa et al, 2007;Cannizzaro et al, 2007;Aisa et al, 2009). The assays used in these assessments, however, have inherent confounding factors.…”

Section: Long-term Effects Of Early Stress On Hippocampal Associated mentioning

confidence: 99%

“…The rodent model of maternal separation has been used in investigating the association between early life stress and long-term impairment of hippocampal-associated function. First, the hippocampus is involved in spatial memory and maternal separation produces long-term spatial memory impairment (Aisa et al, 2007(Aisa et al, , 2009Cannizzaro et al, 2007). Second, the hippocampus contributes to affect regulation and maternal separation increases depressive-like behavior (Aisa et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling

2010

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Early life stress produces long-term alterations in cognition, emotionality, and stress responsiveness. The stress-sensitive hippocampal formation plays a role in producing many of these alterations. We report that adult male rats exposed to early life stress, in the form of maternal separation (MS), exhibit baseline impairment of hippocampal dependent memory and following three weeks of chronic restraint stress (CRS) exhibit heightened anxiety-like behavior and alterations in the morphology of hippocampal CA3 pyramidal neurons. Specifically, as measured by the object placement task, MS offspring demonstrated impaired spatial memory compared with nonmaternally separated rats (NMS). Moreover, compared with NMS rats, subsequent CRS exposure of MS rats increased novelty-induced corticosterone secretion and potentiated anxiety-like behavior as measured by the elevated plus maze. Further, CRS exposed MS rats did not exhibit shortening of apical dendritic length compared with nonstressed MS rats, whereas CRS exposed NMS rats did show significant dendritic shrinkage compared with nonstressed NMS rats. The blunted CRS-induced remodeling of apical dendritic length in MS rats is likely due to a baseline deficiency in dendritic length; MS rats exhibit a trend towards shorter apical dendrites in comparison to NMS rats. CRS exposure in both MS and NMS rats, however, induced a reduction in apical dendritic branching. Finally, there was a significant correlation between apical dendritic length and novelty-induced corticosterone level, while there was not a significant correlation with anxiety-like behavior. Overall, our results suggest preserved but blunted hippocampal structural plasticity in MS rats that is not sufficient to compensate for hippocampal dysfunction and hypersensitivity to CRS.

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Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring

Cited by 21 publications

References 82 publications

5‐HT₁ and 5‐HT₂ Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

5‐HT₁ and 5‐HT₂ Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling

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Effects of pre- and postnatal exposure to 5-methoxytryptamine and early handling on an object-place association learning task in adolescent rat offspring

Cited by 21 publications

References 82 publications

5‐HT1 and 5‐HT2 Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

5‐HT1 and 5‐HT2 Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

Stress and anxiety: Structural plasticity and epigenetic regulation as a consequence of stress

Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling

Contact Info

Product

Resources

About

5‐HT₁ and 5‐HT₂ Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat

5‐HT₁ and 5‐HT₂ Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat