Effects of prediabetes and diabetes on left ventricular and coronary microvascular functions

Erdoğan, Doğan; Yücel, Habil; Uysal, Bayram Ali; Ersoy, Ismail Hakki; Icli, Atilla; Akçay, Salaheddin; Arslan, Akif; Aksoy, Fatih; Özaydın, Mehmet; Tamer, Mehmet Numan

doi:10.1016/j.metabol.2013.02.011

Cited by 37 publications

(34 citation statements)

References 30 publications

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“…Using tissue Doppler and strain/strain rate echocardiography, a recent study showed that LV longitudinal systolic and diastolic function was impaired in both normotensive diabetic and prediabetic patients (15,16). Since coronary blood flow predominantly occurs during diastole, an impairment in LV diastolic function may also play an important role in coronary artery disease impairment in diabetics as well as in prediabetics.…”

Section: Discussionmentioning

confidence: 99%

What is Hiding the Diabetes in the New Left Bundle Branch Block Patients?

Anghel¹

2014

Acta Endo (Buc)

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Background. Diabetes mellitus and new left bundle branch block (LBBB)increase the risk of adverse cardiac outcomes and are considered a coronary artery disease equivalent.Objective. The aim of our study was to determine whether the presence of new or presumably new left bundle branch block could be the first manifestation of coronary artery disease in diabetic patients.Design. We performed a crosssectional analysis which included 273 patients with new LBBB admitted between January 2011 and June 2013 in the Cardiovascular Diseases Institute Iasi. The median follow-up was 7 days (hospitalization period). Patients were divided into two groups according to their glycemic status: diabetic and non-diabetic patients.Results. Our study demonstrates that the presence of new LBBB in diabetic patients is unequivocally associated and could be the first manifestation of an extensive coronary artery disease. Diabetic patients had either one, two or three coronary artery diseases (48.09%) and were more likely to have a decreased ejection fraction (EF) < 50% (p <0.001), almost half of them having an EF <30 %.Conclusions. The association of diabetes mellitus with new LBBB is a high probability criterion for the diagnosis of coronary artery disease, even in asymptomatic patients.Key words: diabetes mellitus, new left bundle branch block, coronary artery disease, left ventricular dysfunction.

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Section: Discussionmentioning

confidence: 99%

What is Hiding the Diabetes in the New Left Bundle Branch Block Patients?

Anghel¹

2014

Acta Endo (Buc)

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“…A recent extensive review has underscored the complex relationship between pre-diabetes, family history of diabetes and onset of cardiovascular diseases [21]. Interestingly, several studies have established a possible association between pre-diabetes and increased cardiovascular risk profile of subjects [22][23][24][25]. Furthermore, family history of diabetes mellitus is not only related to a pure increase in metabolic changes predisposing to the onset of overt diabetes but it seems to overcome the endocrinological alterations and to provoke early lesions even in the vascular walls [21].…”

Section: Obesity and Type 2 Diabetes Mellitus: The Nexusmentioning

confidence: 99%

Childhood Diabetes Mellitus and the Double Burden of Malnutrition: An Emerging Public Health Challenge in Developing Countries

Uwaezuoke¹

2015

J Diabetes Metab

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The 'double burden of malnutrition' refers to the simultaneous existence of both undernutrition and overnutrition in the same population across the life course. Diabetes mellitus (DM) -a major non-communicable disease -has been linked to both chronic undernutrition and obesity; the latter is now assuming prominence in developing countries. The present review aims to highlight the global burden of this non-communicable disease in children and its relationship with the 'double burden of malnutrition'. Type 2 DM has rapidly evolved from a disease of the Western world to a global disease; from a disease of affluence to a disease that now afflicts the poor; and from an adult-onset disease to a disease that is gaining prominence in the pediatric population. Estimates from the International Diabetes Federation show that diabetes affects at least 285 million people worldwide out of which two-thirds occur in developing (low-to middle-income) countries. The global epicenter of diabetes epidemic is located in China and India as Asia has undergone rapid economic development, urbanization and transitions in nutritional status. Overweight and obesity are propelling the worldwide diabetes epidemic. Central obesity is correlated with both insulin resistance and type 2 DM. Moreover, the scourge of chronic undernutrition among children in tropical developing countries may predispose them to malnutrition-modulated diabetes mellitus (MMDM) later in life. Children in these regions are thus faced with a health-related dilemma. There is an urgent need to develop a comprehensive prevention program targeted at reducing diabetes risk and promoting proper nutrition among children in these countries.

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“…Several evidences indicate that pre-diabetes conditions may be associated to increased cardiovascular risk profile of individuals [7][8][9][10] (Figure 1). Shah et al [7] recently demonstrated that obese young patients suffering from pre-diabetes were more prone to show increased common carotid intima-media thickness (a well-known early marker of atherosclerosis) than obese youth with normal glycemic control.…”

Section: Pre-diabetes and Early Impairment In Cardiovascular Systemmentioning

confidence: 99%

“…Apart from the morphological alterations in systemic vascular beds, pre-diabetes is effectively able to worsen the performance of coronary vessels which increases the overall cardiovascular risk of individuals. Erdogan et al [9] evaluated the coronary flow reserve (CFR) in prediabetic, diabetic and normal glycemic patients. The pre-diabetic condition was able to impair the endothelial function of coronary vessels (percentages of pre-diabetic patients with CFR <2%: 17% vs percentages of normal subjects with CFR <2%: 5%, p<0.05) [9].…”

Section: Pre-diabetes and Early Impairment In Cardiovascular Systemmentioning

confidence: 99%

“…Erdogan et al [9] evaluated the coronary flow reserve (CFR) in prediabetic, diabetic and normal glycemic patients. The pre-diabetic condition was able to impair the endothelial function of coronary vessels (percentages of pre-diabetic patients with CFR <2%: 17% vs percentages of normal subjects with CFR <2%: 5%, p<0.05) [9]. Such results were maintained even after adjusting for confounding factors, revealing diabetes as a real predictor of CFR impairment (β=−0.57, p<0.01).…”

Section: Pre-diabetes and Early Impairment In Cardiovascular Systemmentioning

confidence: 99%

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Endothelial Function in Pre-diabetes, Diabetes and Diabetic Cardiomyopathy: A Review

Ciccone

Scicchitano²,

Cameli³

et al. 2014

J Diabetes Metab

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Diabetes mellitus worsens cardiovascular risk profile of affected individuals. Its worldwide increasing prevalence and its negative influences on vascular walls morphology and function are able to induce the expression of several morbidities which worsen the clinical conditions of the patients getting them running towards a reduced survival curve.Although overt diabetes increases the mortality rate of individuals due to its pathogenesis, poor information are in literature about the role of pre-diabetes and family history of diabetes mellitus in the outcome of general population.This emphasizes the importance of early detection of vascular impairment in subjects at risk of developing diabetes.The identification of early stages of atherosclerotic diseases in diabetic persons is a fundamental step in the risk stratification protocols followed-up by physicians in order to have a complete overview about the clinical status of such individuals. Common carotid intima-media thickness, flow-mediated vasodilatation, pulse wave velocity are instrumental tools able to detect the early impairment in cardiovascular system and stratify cardiovascular risk of individuals.The aim of this review is to get a general perspective on the complex relationship between cardiovascular diseases onset, pre-diabetes and family history of diabetes. Furthermore, it points out the influence of diabetes on heart function till the expression of the so-called diabetic cardiomyopathy.

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Effects of prediabetes and diabetes on left ventricular and coronary microvascular functions

Cited by 37 publications

References 30 publications

What is Hiding the Diabetes in the New Left Bundle Branch Block Patients?

What is Hiding the Diabetes in the New Left Bundle Branch Block Patients?

Childhood Diabetes Mellitus and the Double Burden of Malnutrition: An Emerging Public Health Challenge in Developing Countries

Endothelial Function in Pre-diabetes, Diabetes and Diabetic Cardiomyopathy: A Review

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