Effects of progesterone variation on IVF Progesterone variation during controlled ovarian stimulation: effects on in vitro results

Suárez, Onica Armijo; Egea, Guillermo; Martín-Cameán, María; Lobo, Sonia; Sanz, Clara; Iniesta, Silvia; Fernandez, S. Munoz; Sánchez, María José; Silva, Patrı́cia; Hernández, Alicia

doi:10.1080/01443615.2019.1671817

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…The increase in serum P level induced by an LH surge can also affect the expression of genes related to endometrial receptivity, thus, affecting embryo implantation ( 21 ). Another study reported that an increase in serum P level during the late follicular phase affected not only the embryo quality ( 22 , 23 ) but also reduced implantation and clinical pregnancy rates ( 21 , 24 , 25 ). However, there are also views that the increase of serum P level at the late follicular stage does not affect embryo quality and cumulative live birth rate ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

LH level on the antagonist administration day as a predictor of the reproductive outcomes in women with normal ovarian function

Pang,

Wang,

Wang

et al. 2023

Front. Endocrinol.

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IntroductionThe addition of antagonists is mainly based on estrogen level and follicle size, while LH level has not received sufficient attention.In this study, LH Level on the antagonist administration day was used as the main research objective to explore its relationship with laboratory indicators and pregnancy outcomes.Methods and AnalysisWe enrolled 854 patients with normal ovarian function undergoing in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) between May 2021 to May 2022 at the Reproductive Center of Shandong University of Traditional Chinese Medicine.We used the quartile method to group LH levels on the antagonist administration day. There were four groups: Q1 (0.53IU/L≤LH ≤ 1.89IU/L); Q2 (1.89IU/L<LH ≤ 3.01IU/L); Q3 (3.01IU/L<LH≤ 5.29 IU/L); Q4 (5.29IU/L<LH ≤ 8.72IU/L). A total of 452 fresh embryo transplantation cycles and 1726 Frozen embryo transplantation cycles were carried out.ResultThere were significant differences among the four groups in terms of total Gn dosage, E2, P and LH on trigger day, number of retrieved oocytes, number of 2PN embryos, number of blastocysts, Number of ET and fresh ETR.There is a significant correlation between LH on antagonist administration day and Basal LH Level,LH on trigger day,number of oocytes retrieved,number of 2PN embryos,number of blastocysts, number of ET.Using Fresh ETR,Fresh CPR,OHSS and Cumulative CPR as the criterion respectively, the optimal cut-off value for evaluating LH on antagonist administration day was 4.18IU/L,3.99IU/L,4.63IU/L,4.66IU/L.ConclusionThere was a significant positive correlation between LH on the antagonist administration day and number of oocytes retrieved,number of 2PN embryos,number of blastocysts.LH on the antagonist administration day could predict Fresh CPR,OHSS and Cumulative CPR to some extent.

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Section: Discussionmentioning

confidence: 99%

LH level on the antagonist administration day as a predictor of the reproductive outcomes in women with normal ovarian function

Pang,

Wang,

Wang

et al. 2023

Front. Endocrinol.

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“…The increase in serum progesterone could affect the expression of genes related to endometrial receptivity, thereby affecting embryo implantation [ 29 ]. Another studies had reported that the increase of serum progesterone in the late follicular phase would not only affect embryo quality [ 30 , 31 ], but also reduce implantation rate and clinical pregnancy rate [ 32 – 34 ]. Additionally, there were also some studies showing that the increase in serum progesterone levels in the late follicular phase had no effect on embryo quality and cumulative live birth rate [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of flexible low-dose GnRH antagonist on pregnancy outcome in the fresh embryo transfer cycle of IVF-ET: a randomized controlled trial

Feng

Fan

Jiang

et al. 2022

Reprod Biol Endocrinol

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Objective To explore the practicality and effectiveness of a flexible low-dose protocol in the fresh embryo transfer cycle: reducing the total amount of antagonist by increasing the interval between administrations of Cetrotide. Methods A total of 211 patients with normal ovarian reserve who accepted GnRH-ant protocol for IVF-ET were selected, and they were randomized to the flexible low-dose antagonist group (test group, n = 101) or the conventional dose antagonist group (control group, n = 110). The initial dose of Cetrotide in the test group was 0.25 mg every other day, and then the dose was adjusted to 0.25 mg every day based on the subsequent luteinizing hormone (LH) levels. The dosage of Cetrotide in the control group was 0.25 mg per day. The primary outcome was the clinical pregnancy rate. Secondary outcomes included the incidence of premature LH rise, total dosage of Cetrotide, number of oocytes retrieved, number of fertilized oocytes, number of high-quality embryos, biochemical pregnancy rate and ongoing pregnancy rate. Results There was no significant difference in the general condition of the two groups. There was no significant difference in the clinical pregnancy rate (51.49% vs. 48.18%, p = 0.632) or the incidence of premature LH rise (18.81% vs. 15.45%, p = 0.584) between the two groups. However, the amount of Cetrotide used in the test group was significantly lower than that in the conventional dose antagonist group (1.13 ± 0.41 vs. 1.61 ± 0.59 mg, p < 0.001). Conclusion The flexible low-dose antagonist protocol and the conventional dose antagonist protocol were equally effective in people with a normal ovarian reserve in the fresh embryo transfer cycle of IVF-ET.

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“…The high degree of variability in clinical outcomes amongst women undergoing FSH stimulation in IVF treatment is well documented. [37][38][39] Cai et al first reported that these variants were correlated with the altered expression of FSHR at the mRNA and protein levels in granulosa cells. Their results showed that the mRNA and protein expression levels of FSHR in granulosa cells varied due to the ovarian response to exogenous gonadotropin.…”

Section: Discussionmentioning

confidence: 99%

The FSHR G‐29A variant is not associated with the ovarian response to exogenous FSH stimulation

Song

Zhang

et al. 2021

American J Rep Immunol

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A common genetic variant in the follicle stimulating hormone receptor gene (FSHR) 5′untranslated region has been previously reported to influence FSHR gene expression.However, studies on the ovarian response to exogenous gonadotropin stimulation are limited. The aim of this study was to evaluate the association of variants at positions -29 of the FSHR gene with the ovarian response to exogenous FSH stimulation in Chinese women. The genotypes of the FSHR gene were assayed using the Sequenom Mas-sARRAY system. Total RNA and protein was extracted from granulosa cells, and FSHR expression at the mRNA and protein levels was assessed using quantitative PCR and western blotting. Our data revealed that there was no association between the FSHR genotype at the -29 position and the outcome of controlled ovarian stimulation. The expression of FSHR, at both the mRNA and protein levels, was similar amongst the different FSHR genotypes assessed, but was significantly reduced in the low responders.These results indicate that the variants caused by mutations at position -29 are not associated with ovarian response, and the low ovarian response to gonadotropin stimulation may be caused by decreased FSHR expression.

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Effects of progesterone variation on IVF Progesterone variation during controlled ovarian stimulation: effects on in vitro results

Cited by 3 publications

References 15 publications

LH level on the antagonist administration day as a predictor of the reproductive outcomes in women with normal ovarian function

LH level on the antagonist administration day as a predictor of the reproductive outcomes in women with normal ovarian function

The effect of flexible low-dose GnRH antagonist on pregnancy outcome in the fresh embryo transfer cycle of IVF-ET: a randomized controlled trial

The FSHR G‐29A variant is not associated with the ovarian response to exogenous FSH stimulation

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