Effects of prolonged ethanol administration on the hepatic estrogen receptor in the rat

Cronholm, Tomas; Eriksson, Håkan

doi:10.1016/0014-5793(81)80522-4

Cited by 8 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding in man has not been reported previously but is in line with experimental data obtained from rats (21,22). In rats, chronic ethanol administration led to an increase in hepatic ER levels and to a reduction in circulating testosterone levels.…”

Section: Discussionsupporting

confidence: 94%

Ethanol-induced increase in cytosolic estrogen receptors in human male liver: A possible explanation for biochemical feminization in chronic liver disease due to alcohol

Villa¹,

Baldini²,

Rossini³

et al. 1988

Hepatology

View full text Add to dashboard Cite

The hepatic cytosolic estrogen receptor content was measured in liver samples from patients with normal livers and from patients with nonalcoholic cirrhosis, alcoholic cirrhosis and alcoholic hepatitis. The estrogen receptor content of normal liver was 5.2 +/- 3.5 fmoles per mg of cytosolic protein. Levels which were not significantly different from this were found in the samples from patients with nonalcoholic cirrhosis (2.1 +/- 2.0 fmoles per mg of cytosolic protein). The cytosolic estrogen receptor content in the livers of patients with alcoholic cirrhosis who were abstaining was 4.2 +/- 3.6 fmoles per mg of cytosolic protein, but it increased to 10.4 +/- 4.9 fmoles per mg of protein in the livers of patients with alcoholic cirrhosis who were drinking, to 17.3 +/- 8.7 fmoles per mg of protein in the livers of patients with alcoholic hepatitis with cirrhosis and to 22.7 +/- 15.7 fmoles per mg of protein in the livers of patients with alcoholic hepatitis without cirrhosis. Alcohol abuse appeared, therefore, to induce an increase in the estrogen receptor content of human liver, especially in patients who were drinking and had histological evidence of acute liver damage (alcoholic hepatitis). The increase in hepatic estrogen receptor which we have observed may be involved in the molecular mechanisms underlying the feminization of the liver in alcoholic males.

show abstract

Section: Discussionsupporting

confidence: 94%

Ethanol-induced increase in cytosolic estrogen receptors in human male liver: A possible explanation for biochemical feminization in chronic liver disease due to alcohol

Villa¹,

Baldini²,

Rossini³

et al. 1988

Hepatology

View full text Add to dashboard Cite

show abstract

“…The higher hepatic oestrogen receptor levels in women than in men are in accordance with earlier studies of ER content in rat liver (42,43) and lend support to the concept of sex differences in hepatic function (2).…”

Section: Discussionsupporting

confidence: 89%

Enzyme immunoassay of oestrogen receptors in needle biopsies from human liver

Becker

Andersen

Poulsen

et al. 1991

Liver

View full text Add to dashboard Cite

ABSTRACT— For quantitative assessments of sex hormone receptors in liver tissue, ligand binding assays are inconvenient, as they require large biopsies (0.5–1.0 g). The present study shows that it is possible to measure oestrogen receptors (ER) quantitatively in needle biopsy specimens as small as 10 mg by modifications of a commercial enzyme immunoassay employing monoclonal antibodies. Sucrose gradient centrifugation and the dextran charcoal method served as reference methods. A consecutive series of needle biopsies from patients suspected of liver disease were investigated. The biopsies (n = 37) had a median weight of 14 mg and cytosolic protein concentrations > 1 mg/ml (median 1.28 mg/ml). The median ER concentration was 20 fmol/mg cytosolic protein (range 5 to 57 fmol/mg). The intra‐assay coefficient of variation was 8.9%, the inter‐assay 13.2%, and the detection limit 2.7 fmol/ml cytosol. Women had significantly higher ER concentrations (median 22 fmol/mg) compared to male patients (median 16 fmol/mg) (P = 0.007). The enzyme immunoassay measures ER in liver specimens as small as 10 mg, compared to the large tissue specimens necessary for the conventional DCC assay, and the method is a convenient tool for further studies of ER in routine needle biopsies from the liver.

show abstract

Effect of alcohol on sex steroid receptor levels in the hypothalamus and pituitary of male rats

Babichev¹,

Peryshkova²,

Aivazashvili³

et al. 1989

Bull Exp Biol Med

View full text Add to dashboard Cite

Effects of prolonged ethanol administration on the hepatic estrogen receptor in the rat

Cited by 8 publications

References 23 publications

Ethanol-induced increase in cytosolic estrogen receptors in human male liver: A possible explanation for biochemical feminization in chronic liver disease due to alcohol

Ethanol-induced increase in cytosolic estrogen receptors in human male liver: A possible explanation for biochemical feminization in chronic liver disease due to alcohol

Enzyme immunoassay of oestrogen receptors in needle biopsies from human liver

Effect of alcohol on sex steroid receptor levels in the hypothalamus and pituitary of male rats

Contact Info

Product

Resources

About