Effects of pulsed electromagnetic fields on swelling and pain after implant surgery: a double-blind, randomized study

Menini, María; Bevilacqua, Marco Giorgio; Setti, P.E. Levi; Tealdo, Tiziano; Pesce, Paolo; Pera, Paolo

doi:10.1016/j.ijom.2015.10.011

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…This study, similar to our evaluation, found no signi cant different in between those applied with placebo or without device and those with PEMF during the seven days post procedure. Similar negative results have also been reported in a number of PEMF studies: post blepharoplasty [26], breast augmentation [24] and dental implantation procedure [14].…”

Section: Discussionsupporting

confidence: 86%

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Pulsed Electromagnetic Fields for Post-appendectomy Pain Management: A Randomized, Placebo-controlled Trial

Perumal

Latib

Samy

et al. 2021

Preprint

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BACKGROUND Pulsed electromagnetic fields (PEMF) has been shown to improve post-caesarean section pain previously. This study evaluated the efficacy of PEMF in postoperative pain reduction among patients undergoing urgent appendicectomy. METHODS This is a double-blinded, randomized trial. Adults with a clinical diagnosis of acute appendicitis were enrolled. Patients were allocated randomly to receive an active-PEMF device or an inactive device after the surgery in addition to the standard post-operative pain management. The primary endpoint was 12-hour postoperative pain score measured using the Visual Analogue Scale. The primary analysis in this trial compared the two study groups for the median pain score using the Wilcoxon rank sum test. FINDINGS: 118 subjects were randomized, 58 were allocated to the active-PEMF group and 60 to the inactive control group. Median pain score of both intervention groups reduced in a similar fashion over the course of 12 post-operative hours. Median pain score at rest and on movement did not differ significantly 12 hours after the procedure. (W = 1161, p-value 0.3542 for resting pain score; W = 1437.5, p-value 0.3183 for pain on movement). DISCUSSION PEMF was not superior to placebo as an adjunct pain management for up to 12 hours post-appendicectomy. Previously reported effect of PEMF on post-operative pain intensity and analgesia uses in similar surgical settings cannot be verified. Clinical trial registration: National Medical Research Register Malaysia (NMRR-15-670-25805) & Thai Clinical Trials Registry (retrospectively registered at November 01, 2019, Study ID - TCTR20191102002)

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Section: Discussionsupporting

confidence: 86%

“…Several recent studies have shown suggestive results for its use in the pain management of some plastic and oral surgeries. [12][13][14][15] Furthermore, the use of PEMF devices for the promotion of soft tissue healing, and the improvement of circulation has also been approved by the US Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 99%

Pulsed Electromagnetic Fields for Post-appendectomy Pain Management: A Randomized, Placebo-controlled Trial

Perumal

Latib

Samy

et al. 2021

Preprint

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“…On the other hand, Stocchero and colleagues in 2014 [ 15 ] showed negative findings after comparing similar measures of pain score and analgesia use among those who have undergone unilateral mandibular third molar extraction via a randomized blinded study. Similar negative results have also been reported in a number of controlled studies: post blepharoplasty [ 17 ], breast augmentation [ 18 ] and dental implantation procedure [ 14 ].…”

Section: Introductionsupporting

confidence: 84%

Pulsed electromagnetic fields for post-appendicectomy pain management: a randomized, placebo-controlled trial

Perumal

Latib

Samy

et al. 2022

Trials

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Background The value of pulsed electromagnetic field (PEMF) in postoperative pain management, due to the inconsistent findings so far, remains unclear. We extended the evaluation of PEMF on postoperative pain and intravenous (IV) analgesic use to a group of post-appendicectomy Asian patients. Methods This is a double-blinded, randomized trial. Adults with a clinical diagnosis of acute appendicitis were enrolled. Patients were allocated randomly to receive an active-PEMF device or an inactive device after the surgery in addition to the standard postoperative pain management. The primary outcome measure was the 12-h cumulative postoperative pain intensity measured at four different time points using the visual analogue scale. The secondary outcome measure was the total amount of IV fentanyl used (in mg) via PCA over the first 12 postoperative hours. The primary analysis in this trial compared the two study groups for the reported cumulative pain score (both at rest and on movement) and the cumulative amount of IV fentanyl uses over the first 12 postoperative hours using the Wilcoxon rank sum test. Analyses were performed based on the intention-to-treat principal. Multiple imputation was used to handle the missing data assuming that the data were missing at random. Findings One hundred eighteen subjects were randomized; 58 were allocated to the active-PEMF group and 60 to the inactive control group. Pooled mean pain score of both intervention groups by time point declined in a similar fashion over the course of 12 postoperative hours. The 12-h cumulative postoperative pain score at rest and on movement did not differ significantly after the procedure. (W = 1832.5 ~ 1933.0, p-value 0.6192 ~ 0.2985 for resting pain score comparison; W = 1737.0 ~ 1804.5, p-value 0.9892 ~ 0.7296 for movement pain score comparison). For the secondary outcome measure of 12-h total fentanyl use, a comparison between the PEMF vs. placebo arm also revealed no statistically significant difference across all the 20 imputed datasets (W = 1676.5 ~ 1859.0, p-value 0.7344 ~ 0.5234). Discussion PEMF was not superior to placebo as an adjunct pain management for up to 12 h post-appendicectomy. Previously reported effect of PEMF on postoperative pain intensity and analgesia uses in similar surgical settings cannot be verified. Trial registration National Medical Research Register Malaysia (NMRR-15–670-25,805) and Thai Clinical Trials Registry (retrospectively registered on November 01, 2019, Study ID—TCTR20191102002).

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“…Previous studies have demonstrated that PEMFs are a non-invasive and non-pharmacological intervention, and have been reported to repair damaged tissue ( 16 – 18 ). Several clinical studies have demonstrated that PEMFs can effectively alleviate tissue swell, traumatic pain and promote wound healing ( 19 , 20 ). Guerriero et al ( 21 ) described the first reported case of an innovative PEMF therapy, emysimmetric bilateral stimulation (EBS), used to successfully treat refractory skin ulcers in two elderly and fragile patients.…”

Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol contributes to cell proliferation and inhibits apoptosis in pulsed electromagnetic fields treated human umbilical vein endothelial cells in vitro

Cheng¹,

Qu²,

Fu³

et al. 2017

Molecular Medicine Reports

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A variety of pulsed electromagnetic fields (PEMFs) have been experimentally and clinically used in an effort to promote wound healing, although the mechanisms involved remain unknown. The aim of the present study was to investigate the action of a novel protocol of co-treatment with PEMFs and hydroxytyrosol (HTY) on the proliferation and differentiation potential of human umbilical vein endothelial cells (HUVECs). The HUVECs were assigned randomly into three groups: Control, PEMF-treated and PEMF + HT-treated. The intensity of the electromagnetic field used in this protocol was 2.25 mT, the frequency of the bursts was 50 Hz and the application time was 15 min. A Cell Counting kit-8 (CCK-8) assay was used to assess cell proliferation, and cell apoptosis was analyzed by TUNEL apoptosis assay kit and calcein-acetoxymethyl/propidium iodide dual-staining assay. In addition, protein and mRNA expression levels of protein kinase B (Akt), mechanistic target of rapamycin (mTOR), transforming growth factor (TGF)-β1 and p53 were determined by western blotting and reverse transcription-quantitative polymerase chain reaction assays, respectively. The CCK-8 assay demonstrated that HTY contributed to HUVEC proliferation mediated by PEMFs in a time-dependent manner. The Transwell assay and scratch wound results demonstrated that co-treatment of HTY and PEMFs could increase HUVEC migration. Furthermore, the levels of apoptotic cells were reversed by pre-incubation with HTY in the PEMF treatment group, while PEMF treatment alone had no such effect. The proteins and mRNA expression levels of Akt, mTOR, TGF-β1 were elevated in co-treatment of HTY and PEMFs, whereas there was no effect on levels of p53. Therefore, the results indicated that combined exposure of HUVECs to PEMFs and HTY exerted protective effects in HUVECs by promoting cell proliferation and inhibiting apoptosis. In conclusion, to the best of our knowledge, the present study was the first to demonstrate the beneficial roles of HTY and PEMF combined treatment in HUVECs, which may represent an effective treatment for wound healing.

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Effects of pulsed electromagnetic fields on swelling and pain after implant surgery: a double-blind, randomized study

Cited by 8 publications

References 22 publications

Pulsed Electromagnetic Fields for Post-appendectomy Pain Management: A Randomized, Placebo-controlled Trial

Pulsed Electromagnetic Fields for Post-appendectomy Pain Management: A Randomized, Placebo-controlled Trial

Pulsed electromagnetic fields for post-appendicectomy pain management: a randomized, placebo-controlled trial

Hydroxytyrosol contributes to cell proliferation and inhibits apoptosis in pulsed electromagnetic fields treated human umbilical vein endothelial cells in vitro

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