Effects of Riboflavin and Folic Acid Supplementation on Plasma Homocysteine Levels in Healthy Subjects

Family history of hypertension increases risk of preeclampsia in pregnant women: a case-control study

“…Therefore, higher folate intakes may be required to support appropriate placental implantation and growth and development in early pregnancy. The second factor is the effect of folic acid in lowering blood homocysteine levels (45) as hyperhomocysteinemia is a risk factor for a number of pregnancy complications including preeclampsia. (46) The third factor is the effect of folate in improving systemic endothelial function and therefore reducing the risk of such complications as preeclampsia.…”

Folic Acid Supplementation During Early Pregnancy and the Risk of Gestational Hypertension and Preeclampsia

“…Folic acid supplementation can effectively reduce homocysteine. [15][16][17][18] Thus, theoretically, if elevated homocysteine is a cause of gestational hypertension or preeclampsia, folic acid supplementation during early pregnancy may significantly reduce the risk of these outcomes or may change the distribution of the early-onset cases. However, our large cohort study results did not find a protective effect of folic acid supplementation on gestational hypertension or preeclampsia, and, thus, supports the hypothesis that elevated blood homocysteine during pregnancy may be a consequence or a concomitance rather than a cause of gestational hypertension.…”

“…13,14 Hyperhomocysteinemia usually can be corrected by supplementation with folic acid. [15][16][17][18] Thus, a major concern has been raised about whether folic acid supplementation can prevent the occurrence of gestational hypertension or preeclampsia. Three studies from the United States and Canada demonstrated that folic acid-containing multivitamins may greatly reduce the risk of gestational hypertension or preeclampsia.…”

Plasma Homocysteine Levels, Methylene Tetrahydrofolate Reductase Polymorphisms, and the Risk of Thromboembolism in Children

“…Folic acid supplementation has been shown to lower the Hcy levels in individuals with MTHFR polymorphism. 17 As is reflected in our data, it is likely that the effect of having a polymorphism is evident only in folate-deficient individuals. The effect of coexistence of other genetic risk factors with MTHFR polymorphism could also contribute to these differences.…”