Effects of Rimonabant on Active Avoidance Learning in Bulbectomized Rats

Velikova, Margarita; Doncheva, Dobrinka; Tashev, Roman

doi:10.5272/jimab.2020261.2936

Cited by 3 publications

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“…SR-141716A is a selective antagonist of central CB1R, which also has properties of inverse agonist [5]. Our previous research demonstrated that SR-141716A exerted opposite effects upon different routes of administration on the memory of OBX-rats, as well as a stimulatory effect on the locomotor activity of OBX-rats upon i.c.v.-administration [6,7].…”

Section: Introductionmentioning

confidence: 99%

Cb1-Receptor Antagonist Sr-141716a Modulates Locomotor Activity in Obx-Rats

Velikova¹,

Doncheva²,

Tashev³

2022

JofIMAB

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Dysfunction of the endocannabinoid system has been related to depressive-like behavior. In our study, bilateral olfactory bulbectomy (OBX) was used as an animal model of depression. We evaluated the effect of the selective CB1-antagonist SR-141716A (Rimonabant) on the exploratory and locomotor activity of OBX-rats. Rimonabant was administered intragastrically for 14 days to OBX-rats, divided into 3 experimental groups, where the drug was given before; immediately (1-14 days) after; or 14 days (14-28 day) after OBX. Exploratory and locomotor activity of OBX-rats was tested in an Opto-Varimex apparatus. SR-141716A, administered subchronically, intragastrically exerted locomotor stimulating effects in OBX- and sham-operated rats, while the exploratory activity was not affected. The time interval for the drug administration is of significance for the manifestation of the effects on locomotor activity in OBX-rats. SR-141716A applied 14 days before OBX or after the development of a depressive-like state (14-28 days after OBX), but not immediately after OBX (1-14 days) aggravated the OBX-induced hyperlocomotor state.

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Section: Introductionmentioning

confidence: 99%