2006
DOI: 10.1016/j.pnpbp.2005.06.013
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Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat

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Cited by 24 publications
(13 citation statements)
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“…Inhibition of NO synthase (NOS) by L-NAME has been described to reduce both NREMS and REMS in rats [32]; however, also the exact opposite effect has been reported [33]. The specific neuronal NOS (nNOS) inhibitor, 7-nitro-indazole, has been demonstrated to decrease REMS exclusively [33], to reduce both REMS and NREMS as well as EEG amplitude [34], or to have most of all an effect on NREMS [35], respectively. Inhibition of soluble guanylyl cyclase, which generates cGMP upon activation by NO, promoted NREMS and suppressed REMS [36].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Inhibition of NO synthase (NOS) by L-NAME has been described to reduce both NREMS and REMS in rats [32]; however, also the exact opposite effect has been reported [33]. The specific neuronal NOS (nNOS) inhibitor, 7-nitro-indazole, has been demonstrated to decrease REMS exclusively [33], to reduce both REMS and NREMS as well as EEG amplitude [34], or to have most of all an effect on NREMS [35], respectively. Inhibition of soluble guanylyl cyclase, which generates cGMP upon activation by NO, promoted NREMS and suppressed REMS [36].…”
Section: Discussionmentioning
confidence: 99%
“…Divergent findings might be due to variances in times of treatment [37] and/or drug dose [30], [35]. In addition, it is important to note that not all effects of NO must be mediated via cGMP and PRKGs.…”
Section: Discussionmentioning
confidence: 99%
“…Nitric oxide (NO) performs multiple roles in CNS function like 539 maintaining cognitive function, neurotransmitter secretion, sleep 540 wake cycle, appetite control body temperature homeostasis and 541 neuroprotection [107]. It has been well documented that NO seems 542 to protect the neurons from excitotoxicity through its effect on 543 NMDA receptors as well as caspase inhibition [108].…”
Section: Modulators Of Nos 538mentioning
confidence: 99%
“…In fact, NO meets some of the criteria for sleep regulatory substances (Gautier-Sauvigne et al, 2005). Systemic administration of the nNOS inhibitors 3-bromo-7-nitroindazole (Cavas and Navarro, 2006) and N G -nitro-L-arginine (L-NAME; Kapas et al, 1994b) during the light phase of the LD cycle reduced the amount of time spent in SWS, as did intracerebroventricular injection (Kapas et al, 1994a). However, when the same compound was administered at dark onset, only suppression of SWA occurred and time spent in SWS increased (Ribeiro and Kapas, 2005).…”
Section: Neuronal No As a Sleep-inducing Factor: Local Regulation Of mentioning
confidence: 99%