2017
DOI: 10.1515/acve-2017-0028
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Effects of Selenium and Thyroid Hormone Deficiency on Peritoneal Macrophages Adhesion and Occurrence of Natural IGM Antibodies in Juvenile Rats

Abstract: Both selenium, as an effector and regulator of antioxidative enzymes activity, and thyroid hormones are potent immunomodulators. Besides, selenium incorporated into iodothyronine deiodinases is involved in the thyroid function and thus indirectly regulates the immune response. Studies of the mutual infl uence of selenium and thyroid hormones on the immune response are scarce, hence we analyzed the effects of an iodothyronine deiodinases blocker, propylthiouracil (PTU), and selenium defi ciency on the function … Show more

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“…Selenium can signifi cantly improve bird antibody immune responses in natural and pathological conditions [3,[6][7][8], although an overly elevated amount of this micronutrient in the diet (3-60 mg/kg) can decrease body weight and reduce the immune response [6,9]. Moreover, selenium incorporated into iodothyronine deiodinases may infl uence the thyroid function and via the thyroid other immunological organs [10].…”
Section: Introductionmentioning
confidence: 99%
“…Selenium can signifi cantly improve bird antibody immune responses in natural and pathological conditions [3,[6][7][8], although an overly elevated amount of this micronutrient in the diet (3-60 mg/kg) can decrease body weight and reduce the immune response [6,9]. Moreover, selenium incorporated into iodothyronine deiodinases may infl uence the thyroid function and via the thyroid other immunological organs [10].…”
Section: Introductionmentioning
confidence: 99%