Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets

Schäfer, Klaus; Kyriakopoulos, Antonios; Gessner, H.; Grune, Tilman; Behne, D.

doi:10.1016/j.jtemb.2004.03.003

Cited by 40 publications

(34 citation statements)

References 32 publications

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“…Fructose-fed rats developed severe insulin resistance and fatty livers based on an activation of protein phosphatase 2A, sterol regulatory element binding protein 1-c and fatty acid synthase as the consequence of the increased PTP1B activity. In another rat trial, feeding diets containing 0.30-mg Se/kg diet increased the liver triglyceride content in these animals 1.5-fold in comparison to their Sedeficient companions [61]. Our data could confirm higher triglyceride contents in the livers of Se-supplemented rats (Table 1).…”

Section: Influence Of Se and Its Compounds At Different Dietary Levelsupporting

confidence: 57%

Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats

Mueller

Bosse

Most

et al. 2009

The Journal of Nutritional Biochemistry

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Section: Influence Of Se and Its Compounds At Different Dietary Levelsupporting

confidence: 57%

Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats

Mueller

Bosse

Most

et al. 2009

The Journal of Nutritional Biochemistry

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“…Ratio of both eicosapentaenoic (C20:5n-3) and docosahexaenoic (C22:6n-3) fatty acids were higher (P<0.05) in LS+Se groups compared to the C and LS groups. This is in agreement with Schäfer et al (2004) who found that Se deficiency significantly reduced levels of n-3 series fatty acids such as docosahexaenoic (C22:6n-3) present in liver phospholipids. Ratio of n-6/n-3 fatty acids in milk was lower (P<0.05) in the experimental LS+Se group compared to the C and LS groups which is also in agreement with Schäfer et al (2004) who found that due to the Se deficiency the conversion of LA to arachidonic acid was reduced and the ratio of n-6/n-3 fatty acids was increased in liver phospholipids.…”

Section: Milk Fatty Acid Compositionsupporting

confidence: 93%

“…The mechanism of bacterial fatty acids saturation in rumen disturbs increment of unsaturated fatty acids in milk (L ourenço et al, 2010). Selenium (Se) plays a key role in antioxidant enzymes (Antunović et al, 2013) and it is known that Se deficiency affects the lipid concentration and fatty acid composition in liver (Schäfer et al, 2004). Selenium as a part of a selenoenzyme type I iodothyronine deiodinase, which is responsible for the majority of peripheral conversions of thyroxine (T 4 ) to the active form 3,3′,5-triiodothyronine (T 3 ).…”

Section: Introductionmentioning

confidence: 99%

Plasma and milk fatty acid composition as a response to dietary n-3 fatty acids and selenium in periparturient Holstein cows

et al. 2017

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Linseed is well known for abundant content of α-linolenic acid why it has been widely used as a source of n-3 fatty acid. Higher ratio of polyunsaturated fatty acids can increase lipid peroxidation. Selenium (Se) plays a key role in antioxidant enzymes and can therefore be regarded for use in attempts focused on protection of fatty acids from oxidation. The organic Se has been shown to have higher bioavailability compared to the inorganic selenium. The aim of this research was to determine the influence of dietary replacement of n-6 with n-3 polyunsaturated fatty acids on plasma and milk fatty acid composition in the dairy cows. The experiment was conducted on 30 dairy Holstein cows in the period from parturition until the 3 rd week of lactation. Soybean meal from control (C) group was replaced with grounded linseed in the both experimental (LS and LS+Se) groups. In addition to that, in the 2 nd experimental (LS+Se) group sodium selenite from premix was replaced with organic selenium. Blood and milk samples were collected at 21 st day of lactation and fatty acids were determined using gas chromatography from it. Feeding dairy cows during transition period with linseed showed a positive impact on milk fatty acid composition by increasing (P<0.05) the proportion of n-3 fatty acids. Proportion of α-linolenic fatty acid increased (P<0.05) in the blood of both groups fed with linseed, but was significant (P<0.05) only in milk of LS+Se group. Such data indicated that the addition of organic selenium acted favourable on α-linolenic fatty acid increase in milk. During early postpartum period addition of linseed in meal of dairy cow's increased (P<0.05) ratio of oleic acid, but in combination with organic source of selenium this increase was not evident (P>0.05).

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“…It is well known that Se defi ciency dramatically decreases GPx activity [2] and it has been demonstrated that Se supplementation increases enzyme activity [3,4] . Se proteins are also implicated in many other different functions, and an indirect effect of Se on the desaturation and the absorption of fatty acids has been demonstrated [5] . Pyridoxine is also involved in lipid metabolism, particularly in fatty acid desaturation [6] .…”

Section: Introductionmentioning

confidence: 99%

Vitamin B<sub>6</sub> Deficiency and Dietary Fats: Effects on Lipid Composition and Glutathione Peroxidase Activity in Rat Liver

et al. 2006

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Dietary selenium, vitamin B₆ and fatty acids modulate both tissue acyl composition by regulating polyunsaturated fatty acid metabolism and antioxidant defences by influencing glutathione peroxidase activity. Alteration in the intake of one of them could therefore lead to different results depending on the intake of the others. To clarify this complex relationship, in the present study we have evaluated the modifications occurring in fatty acid composition and glutathione peroxidase activity in total liver and liver microsomes of rats fed diets containing the same amount of selenium, but different vitamin B₆content and fatty acid composition. Our data indicate that both acyl composition and glutathione peroxidase activity are greatly influenced not only by vitamin B₆deficiency, but also by the diet unsaturation degree. This study underlines that not only selenium availability but also other nutrients can modulate glutathione peroxidase activity.

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Effects of selenium deficiency on fatty acid metabolism in rats fed fish oil-enriched diets

Cited by 40 publications

References 32 publications

Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats

Regulation of the insulin antagonistic protein tyrosine phosphatase 1B by dietary Se studied in growing rats

Plasma and milk fatty acid composition as a response to dietary n-3 fatty acids and selenium in periparturient Holstein cows

Vitamin B<sub>6</sub> Deficiency and Dietary Fats: Effects on Lipid Composition and Glutathione Peroxidase Activity in Rat Liver

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