Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial

Kamali, Alireza; Amirani, Elaheh; Asemi, Zatollah

doi:10.1007/s12011-019-1636-7

Cited by 21 publications

(21 citation statements)

References 41 publications

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“…In the study, the results of reduced CAT, GSH-Px activities and GSH levels in CAD were consistent with the results of other studies [ 7 , 8 , 24 ] , while findings of elevated SOD activity in CAD patients were not supported by other researchers [ 7 , 24 ] . The significant increase in MDA value was consistent with those reported by other authors [ 22 , 24 ] . However, the decrease in the TAS level agree with the data of Tani et al [ 25 ] .…”

Section: Discussionsupporting

confidence: 93%

“…Cardiac surgery with CPB leads to ischemia reperfusion-mediated oxidative stress. Inflammation and oxidative stress are associated with the pathogenesis of atherosclerosis and increase the risk of postoperative atrial fibrillation and graft failure [ 22 ] Trace elements are necessary for a wide range of primary cellular functions and are especially crucial for various enzymes involved in the generation and neutralization of ROS that are normally produced by the cell [ 23 ] . Trace elements such as Cu and Co may contribute to myocardial dysfunction [ 4 ] .…”

Section: Discussionmentioning

confidence: 99%

“…These results show that low levels of Cu, Zn and Se can present a risk for CAD. It has been reported that the majority of cardiac surgery patients presented a significant Se deficiency before surgery, which was increased by the intra-operative procedure [ 22 ] . There was no study determining the levels of trace elements As, Be, Co, Be, As, Cr, Li, Ti and V.…”

Section: Discussionmentioning

confidence: 99%

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Evaluations of Antioxidant Enzyme Activities, Total Sialic Acid and Trace Element Levels in Coronary Artery Bypass Grafting Patients

Yıldız

Ekin

Şahinalp

2021

Braz J Cardiovasc Surg

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Introduction In this study, patients before and after cardiac surgery with cardiopulmonary bypass (CPB) and control subjects were evaluated for erythrocyte glutathione peroxidase, catalase and superoxide dismutase enzyme activities, in addition to glutathione, malondialdehyde, serum total sialic acid, lipid-bound sialic acid, total antioxidant status, trace elements and mineral levels. The correlation of these variables with coronary artery disease (CAD) was also assessed. Methods A total of 30 CAD patients and 30 control subjects were included in the study. CAD patients were divided into three groups: before surgery (BS), first day after surgery (1 st day AS) and seventh day after surgery (7 th day AS). Results Malondialdehyde (MDA) and total sialic acid (TSA) levels were significantly higher in CAD (BS) than in the control group ( P <0.05, P <0.05). In addition, GSH and TAS levels were significantly lower in the 1st day AS group than in the control group ( P <0.001, P <0.01). Moreover, Co, Cu, Mg, Se, V and Zn levels were significantly lower in CAD (BS) group than in the control group ( P <0.01, P <0.01, P <0.01, P <0.01, P <0.05, P <0.001). Conclusions It was concluded that the levels of LDL-C, total cholesterol, triglycerides and CRP significantly associated with parameters, as well as Cu, Ca and SOD activity, should be measured together to monitor CAD. It is also considered that measuring TSA and MDA might be an appropriate choice for biomarkers of CAD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Evaluations of Antioxidant Enzyme Activities, Total Sialic Acid and Trace Element Levels in Coronary Artery Bypass Grafting Patients

Yıldız

Ekin

Şahinalp

2021

Braz J Cardiovasc Surg

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“…The new cooked ham used for this clinical trial was enriched with vitamin C, selenium, and zinc. Selenium can modulate free radicals and inhibit NF-κB, thereby decreasing oxidative damage and suppressing biomarkers such as MDA [ 67 ]. Vitamin C is also a strong antioxidant [ 68 ], and zinc is one of the most important trace elements in the body, not only because it is part of more than 300 enzymes but also because it is a key element in antioxidant responses [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

“…There are multiple articles that highlight the antioxidant capacity of these three elements. A clinical trial carried out by Kamali et al [ 67 ] showed a significant decrease in MDA levels in subjects who ingested 200 μg of selenium. On the other hand, another study showed no significant changes in MDA and SOD levels after the consumption of 250 and 500 mg of vitamin C, respectively [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial

et al. 2021

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The aim of the study was to analyze how cardiovascular risk factors can be modified using nutritionally improved cooked ham enriched with a pool of antioxidants to influence relevant metabolic targets. Sixty-five untreated subjects (49.2% males, 50.8% females, mean age 40.92 ± 9.03 years) with total cholesterol level ≥180 mg/dL or LDL cholesterol ≥130 mg/dL participated in a 8-weeks randomized, double-blind controlled trial. Participant in the intervention group (51.5% males, 48.5% females, mean age 41.6 ± 9.8 years and mean BMI 25.1 ± 3.6 kg/m2) consumed cooked ham enriched with antioxidants (100 g/d) and controls (49.9% males, 53.1% females, mean age 40.2 ± 8.3 years and mean BMI 26.3 ± 3.2 kg/m2) received placebo. At 8 weeks, oxidized LDL decreased significantly between experimental and placebo groups (p < 0.036). Experimental group differences were also significant (p < 0.05). Similar findings in malondialdehyde, total cholesterol, high-sensitivity C-reactive protein, and interleukin 6 were observed in the intervention group. Significant between-group differences in these variables were also found, except for total cholesterol and interleukin 6. The effects on inflammation and oxidation support the direct action of these antioxidants on the etiopathogenic factors of atheromatous plaque. We also observed an improvement in the lipid profiles among the subjects.

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The Effect of Selenium Supplementation on Clinical Outcomes, Metabolic Profiles, and Pulsatility Index of the Uterine Artery in High-Risk Mothers in Terms of Preeclampsia Screening with Quadruple Test: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Mesdaghinia

Shahin

Ghaderi

et al. 2022

Biol Trace Elem Res

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Data on the effects of selenium (Se) supplementation on clinical outcomes, metabolic profiles, and pulsatility index (PI) in high-risk mothers in terms of preeclampsia (PE) screening with quadruple tests are scarce. This study evaluated the effects of Se supplementation on clinical outcomes, metabolic profiles, and uterine artery PI on Doppler ultrasound in high-risk mothers in terms of PE screening with quad marker. The current randomized, double-blind, placebo-controlled trial was conducted among 60 high-risk pregnant women screening for PE with quad tests. Participants were randomly allocated into two groups (30 participants each group), received either 200 µg/day Se supplements (as Se amino acid chelate) or placebo from 16 to 18 weeks of pregnancy for 12 weeks. Clinical outcomes, metabolic profiles, and uterine artery PI were assessed at baseline and at the end of trial. Se supplementation resulted in a significant elevation in serum Se levels (β 22.25 µg/dl; 95% CI, 18.3, 26.1; P < 0.001) compared with the placebo. Also, Se supplementation resulted in a significant elevation in total antioxidant capacity (β 82.88 mmol/L; 95% CI, 3.03, 162.73; P = 0.04), and total glutathione (β 71.35 µmol/L; 95% CI, 5.76, 136.94; P = 0.03), and a significant reduction in high-sensitivity C-reactive protein levels (β − 1.52; 95% CI, − 2.91, − 0.14; P = 0.03) compared with the placebo. Additionally, Se supplementation significantly decreased PI of the uterine artery in Doppler ultrasound (β − 0.09; 95% CI, − 0.14, − 0.04; P = 0.04), and a significant improvement in depression (β − 5.63; 95% CI, − 6.97, − 4.28; P < 0.001), anxiety (β − 1.99; 95% CI, − 2.56, − 1.42; P < 0.001), and sleep quality (β − 1.97; 95% CI, − 2.47, − 1.46; P < 0.001). Se supplementation for 12 weeks in high-risk pregnant women in terms of PE screening with quad marker had beneficial effects on serum Se level, some metabolic profiles, uterine artery PI, and mental health. IRCT Registration: htpp:// www.irct.ir ; identifier IRCT20200608047701N1.

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Effects of Selenium Supplementation on Metabolic Status in Patients Undergoing for Coronary Artery Bypass Grafting (CABG) Surgery: a Randomized, Double-Blind, Placebo-Controlled Trial

Cited by 21 publications

References 41 publications

Evaluations of Antioxidant Enzyme Activities, Total Sialic Acid and Trace Element Levels in Coronary Artery Bypass Grafting Patients

Evaluations of Antioxidant Enzyme Activities, Total Sialic Acid and Trace Element Levels in Coronary Artery Bypass Grafting Patients

Effects of the Consumption of Low-Fat Cooked Ham with Reduced Salt Enriched with Antioxidants on the Improvement of Cardiovascular Health: A Randomized Clinical Trial

The Effect of Selenium Supplementation on Clinical Outcomes, Metabolic Profiles, and Pulsatility Index of the Uterine Artery in High-Risk Mothers in Terms of Preeclampsia Screening with Quadruple Test: a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

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