Effects of Shenque Moxibustion on Behavioral Changes and Brain Oxidative State in Apolipoprotein E-Deficient Mice

Liu, Juntian; Zhao, Baixiao; Cui, Yingxue; Huang, Yuhai; Huang, Chang; Huang, Jian; Han, Li; Lao, Lixing

doi:10.1155/2015/804804

Cited by 12 publications

(21 citation statements)

References 34 publications

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“…Moxibustion is particularly good at supplementing energy ( qi ), and thus, it has been often applied to patients who experience fatigue or similar conditions [ 25 ]. Modern scientific studies also have shown that moxibustion is effective in alleviating chronic fatigue [ 26 – 28 ], and some parts of its mechanism have been reported to be related to activation of the vagus nerve [ 26 ], reduction of oxidative damage [ 26 , 27 , 29 ], improvement of inflammation [ 30 ], regulation of the HPA axis [ 10 ], and upregulation of hippocampal progranulin [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Moxibustion for cancer-related fatigue: study protocol for a randomized controlled trial

Kim

Lee

et al. 2017

BMC Complement Altern Med

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BackgroundCancer-related fatigue is one of the most common symptoms experienced by cancer patients, and it diminishes their quality of life. However, there is currently no confirmed standard treatment for cancer-related fatigue, and thus, many patients who suffer cancer-related fatigue seek complementary and alternative medicines such as moxibustion. Moxibustion is one of the most popular therapies in traditional Korean medicine used to manage fatigue. Recent studies have also demonstrated that moxibustion is effective for treating chronic fatigue. However, there is insufficient evidence supporting the effect of moxibustion against cancer-related fatigue. The aim of this study is to assess the efficacy and safety of moxibustion treatment for cancer-related fatigue.Methods/designA multi-center, three-armed parallel, randomized controlled trial will be conducted. Ninety-six patients with cancer-related fatigue will be recruited from three clinical research centers. They will be randomly allocated to one of three groups in a 1:1:1 ratio. The moxibustion group will receive moxibustion treatment at CV8, CV12, LI4 and ST36. The sham moxibustion group will receive sham moxibustion at non-acupoints. Both the moxibustion and sham moxibustion groups will receive 30-min treatments twice a week for 8 weeks. The usual care group will not receive moxibustion treatment. All participants will be educated via a brochure on how to manage cancer-related fatigue in daily life. The outcome measurements will be evaluated at baseline, week 5, week 9, and week 13 by assessors who are blinded to the group allocation. The primary outcome measure will be the mean change in the average scores of the Brief Fatigue Inventory before and after treatments between groups. The secondary outcome measures will be the mean difference in changes from baseline of the Brief Fatigue Inventory, functional assessments of cancer therapy-fatigue, European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C-30 scores, and Montreal Cognitive Assessment scores between groups. Safety will be assessed by monitoring adverse events at each visit.DiscussionThe results of this study will provide evidence to confirm whether moxibustion can be used as a therapeutic option for treating cancer-related fatigue.Trial registrationClinical Research Information Service KCT0002170. Registered 16 December 2016.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-017-1856-3) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Moxibustion for cancer-related fatigue: study protocol for a randomized controlled trial

Kim

Lee

et al. 2017

BMC Complement Altern Med

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“…Therefore, it may improve microcirculation and promote metabolism of the body. Low concentrations of moxa smoke have no noticeable damage to vascular endothelium, while medium concentrations can cause a certain degree of vascular endothelium damage [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Components in Moxa Smoke by GC‐MS and Preliminary Discussion on Its Toxicity and Side Effects

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Moxibustion plays an important role in the prevention and treatment of diseases and the promotion of human health. In this study, the components in moxa smoke from Jiangxi Poai Biotechnology Co., Ltd., namely, Qing moxa sticks, were absorbed by five solvents (cyclohexane, ethyl acetate, n-butanol, anhydrous ethanol, and water) and identified by gas chromatography-mass spectrometry. The identification results of the smoke from the Qing moxa sticks that was absorbed in liquid are as follows: a total of 294 compounds were identified, including 139 in cyclohexane, 145 in ethyl acetate, 60 in n-butanol, 89 in anhydrous ethanol, and 77 in water, and of those, 112 toxic compounds were identified. Furthermore, Ingenuity Pathway Analysis software and the PubChem database were successfully applied to analyze the toxic compounds. There were 812 target proteins related to the toxic components, 25 molecular networks, and 54 biological pathways. The results showed that the toxic compounds of moxa smoke may have some side effects on the heart, liver, and kidney of humans. This study revealed that the components of moxa smoke are complex and diverse. Due to the findings of toxic compounds in moxa smoke, we recommend that moxibustion rooms should be equipped with ventilation equipment or enough artificial ventilation to ensure the health of patients and practitioners.

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“…Excessive lipid in the plasma will enter the intima of the artery after injury and was accumulated in the artery wall. Deposit in the subintimal space leads to lipid deposition and early atherosclerotic lesions (22). The expression levels of LDL-C, TC and Glu in the model group induced by high-fat diet were significantly higher than those in the normal control group.…”

Section: Discussionmentioning

confidence: 99%

Analysis of interleukin‑17 and interleukin‑18 levels in animal models of atherosclerosis

Tang

2019

Exp Ther Med

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This study investigated the correlation between the levels of interleukin (IL)-17 and IL-18 and atherosclerotic plaques. A total of 60 Apo E gene (Apo E-/-) mice were fed with high-fat diet in the model group and 20 wild male C57BL/6 mice were fed with the basic diet in the control group. The serum levels of IL-17 and IL-18 were determined by enzyme-linked immunosorbent assay. Carotid artery ultrasonography was performed and divided into stable plaque, unstable plaque and non-plaque groups. The severity of plaque was estimated by semi-quantitative method and divided into grades I, II and III. The expression levels of low-density lipoprotein cholesterol, plasma total cholesterol and blood glucose level in the model group induced by high-fat diet were significantly higher than those in the control group (P<0.05). The level in the model group was significantly higher than in the control group at the 16th week (P<0.05). The expression of IL-17 and IL-18 in the model group was significantly higher than that in the control group (t=6.903, 11.02, P<0.05). The concentration of IL-17 and IL-18 in the non-plaque group was significantly lower than that in the stable plaque and unstable plaque groups (P<0.05). The concentration of IL-17 and IL-18 in the stable plaque group was significantly lower than that in the unstable plaque group (P<0.05). Based on the correlation of IL-17 and IL-18 expressions in the model group, the expression of IL-18 increased with the expression of IL-17, indicating that the expression of IL-17 was positively correlated with that of IL-18 (r=0.7195, P<0.001). In conclusion, serum IL-17 and IL-18 played an important role in the formation and development of atherosclerotic plaque, and were related to the stability and severity of plaque. The expression of IL-17 and IL-18 was positively correlated.

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Effects of Shenque Moxibustion on Behavioral Changes and Brain Oxidative State in Apolipoprotein E-Deficient Mice

Cited by 12 publications

References 34 publications

Moxibustion for cancer-related fatigue: study protocol for a randomized controlled trial

Moxibustion for cancer-related fatigue: study protocol for a randomized controlled trial

Analysis of the Components in Moxa Smoke by GC‐MS and Preliminary Discussion on Its Toxicity and Side Effects

Analysis of interleukin‑17 and interleukin‑18 levels in animal models of atherosclerosis

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