Effects of Simo decoction on gastric motility of diabetic rats

Abstract

Gastroparesis is an extremely common condition among diabetic patients. The upper gastrointestinal symptoms of gastroparesis, such as early satiety and postprandial fullness, are associated with delayed gastric emptying. 1 Previous evidence has revealed that reduced antral contractions and increased postprandial antral diameter are responsible for delayed gastric emptying. 2 Although the pathophysiological mechanism of gastroparesis has not been fully elucidated, the etiology of this disorder is noted as follows: vagal

Huanglian‐banxia promotes gastric motility of diabetic rats by modulating brain‐gut neurotransmitters through MAPK signaling pathway

“…In addition, the therapy aimed at regulating brain‐gut neurotransmitter has been effective in delayed gastric emptying 48 . Many TCM prescriptions have obvious effects in this respect and were gradually receiving attention 49,50 . The search for brain‐gut neurotransmitters from endogenous substances for the treatment of gastroparesis is maybe promising.…”

“…48 Many TCM prescriptions have obvious effects in this respect and were gradually receiving attention. 49,50 The search for brain-gut neurotransmitters from endogenous substances for the treatment of gastroparesis is maybe promising.…”

“…48 Many TCM prescriptions have obvious effects in this respect and were gradually receiving attention. 49,50 The search for brain-gut neurotransmitters from endogenous substances for the treatment of gastroparesis is maybe promising. Given the significantly higher prevalence of diabetic gastroparesis in women, 52,53 exploring gender differences in the effect of HL-BX on gastric motility would be useful for clinical management.…”

Safety and efficacy evaluation of Simo decoction and Arecae semen in herbal medicine practice

“…In the field of traditional Chinese patent medicine (TCPM), Simo decoction (Simo decoction oral solution) is distinguished by its effectiveness in treating various symptoms, including vomiting, abdominal bloating, abdominal pain, constipation, and feeding intolerance in premature infants, as well as constipation and functional dyspepsia in older adults [ [16] , [17] , [18] , [19] ]. A key component of this decoction is Arecae semen , traditionally used for its properties in eliminating intestinal parasites, alleviating food stagnation, stimulating qi, promoting diuresis, and preventing malaria [ 20 ].…”

Simo decoction curing spleen deficiency constipation was associated with brain-bacteria-gut axis by intestinal mucosal microbiota

“…The combination of these drugs can enhance the immunity, invigorate the spleen and replenish Qi . Furthermore, it is found that SMD can restore and improve gastrointestinal motility by promoting gastric emptying and regulating hormones related to gastrointestinal motility ( Li et al, 2020 ; Yan et al, 2022 ). SMD could also treat constipation by improving the transcription level of genetic information of intestinal microbiota, increasing tyrosine-protein kinase growth factor receptors, and protecting the intestinal mucosal barrier ( Dai et al, 2013 ; He et al, 2017 ; Fan et al, 2018 ; Hui et al, 2018 ; Xiao and Liu, 2018 ).…”