Effects of single- and double-layered resorbable membranes and platelet-rich fibrin on bone healing

Tayşi, Mert; Atalay, Belir; Cankaya, Burak; Yıldırım, Sami

doi:10.1007/s00784-017-2259-z

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…The scarce angiogenesis that was observed, in comparison with that obtained by the other groups, played a crucial role in bone neogenesis and in all regenerative processes because sufficient nutritional support is essential [30]. Fibrous connective tissue, which prevents osteogenesis entirely or partially [32], was observed at the base of the Ca-Ms (Fig 5b). It is hypothesized that cells cannot perform matrix calcification due to the lack of bone-derived growth and differentiation factors in bone defects [33].…”

Section: Discussionmentioning

confidence: 73%

Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration

et al. 2019

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Section: Discussionmentioning

confidence: 73%

Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration

et al. 2019

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“…The rats were divided into three experimental groups using one layer of collagen membrane, two layers of collagen membranes and platelet-rich fibrin (PRF) membranes and a control group without any covering membrane. After 7 and 28 days, the histomorphometric analysis showed that the group that received PRF membranes had higher level of bone neoformation and a lower level of fibrosis when compared with the other groups [22].…”

Section: Discussionmentioning

confidence: 94%

Horizontal Alveolar Ridge Augmentation in the Mandibular Posterior Region Using Biphasic Calcium Phosphate and Leukocyte- and Platelet rich fibrin (L-PRF): A case report.

Massuda,

Pereira Júnior,

Armond

et al. 2023

Braz. J. Implantol. Health Sci.

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In bone defects caused by tooth loss, tissue reconstructions are necessary to enable prosthetic rehabilitation with dental implants. Diverse techniques and materials of different origins are used for this purpose. Leukocyte- and Platelet-Rich Fibrin (L-PRF) has been used in association with osteoconductive biomaterials in procedures of bone regeneration and for covering grafted areas. The aim of this article was to demonstrate a clinical case of bone grafting in the posterior region of the mandible, performed with the use of synthetic biomaterial composed of biphasic calcium phosphate associated with Leukocyte- and Platelet-Rich Fibrin for performing bone augmentation in an alveolar ridge with a horizontal defect, thereby enabling later installation of dental implants and prosthetic rehabilitation in the region. Keywords: bone graft, biomaterials, leukocyte- and platelet-rich fibrin, bone substitutes, dental implants.

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“…Faot, Deprez, Vandamme, Camargos, Pinto, Wouters, van den Oord, Quirynen and Duyck [8] also reported similar ndings regarding the reduction of trabecular connectivity (Tb.Pf) during early bone healing periods in tibiae of rabbits treated with standard PRF membranes. The fact of PRF had a limited effect on bone repair can be associated with the signi cant decrease of release growth factors, such as TGF-ß1, and PDGF, after 3, 7, and 14 days, which does not seem to be long enough to stimulate the bone defect environment [41,42]. Moreover, the histological description of PRF group samples showed that bone healing occurs along the membrane but not inside the PRF clot.…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich fibrin (PRF) membrane isolated and injectable-PRF-mixed particulate bovine bone graft in rattibiae non-critical defects healing

Soares

Carrera

Alves

et al. 2023

Preprint

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Objectives To investigate the efficacy of both platelet-rich fibrin (PRF) membrane isolated and injectable PRF (i-PRF) mixed with deproteinized bovine bone mineral (DBBM) in the treatment of rat tibiae non-critical defects. Materials and methods Non-critical bone defects in the tibiae (3.5mm x 1.5mm) of sixty-four rats were made and filled with different materials according to each experimental group: CO: bone defects filled with blood clot; PRF: PRF membranes obtained by fibrin protocol; BO: DBBM isolated and SB: i-PRF mixed with DBBM. Micro–computed tomography (µCT), histological/ histomorphometric analysis, and molecular markers expression were conducted after 15 and 45 days. Results Cortical area analyses by µCT showed superior results for bone formation and cortical thickness in PRF group in comparison to the control group. The PRF exhibited comparable results with BO and SB groups in early periods. However, the DBBM isolated seems to promote more new bone formation in later periods. Histomorphometry analysis demonstrated similar percentage of newly formed bone among the groups at 15 and 45 days. The i-PRF mixed to DBBM bone not enhance the bone formation in comparison to DBBM alone in both µCT and histomorphometry analyses. Bone molecular markers expression demonstrated higher expression of Alpl, Bglap, and Runx2 genes for BO compared to the other groups. Conclusions In conclusion, the PRF, DBBM, and SB groups promoted higher bone formation in rat tibiae non-critical defects in comparison to the control group. However, the addition of i-PRF to DBBM did not improve the DBBM potential in bone healing. Clinical relevance: This pre-clinical study produced insights about the use of modified protocols for obtaining PRF by a low-speed concept which has been associated with more concentration of growth factors and better results than standard PRF protocol.

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Effects of single- and double-layered resorbable membranes and platelet-rich fibrin on bone healing

Abstract: Histopathologic evaluation has been carried out regarding the effect of platelet-rich fibrin and collagen membranes applied on bone recovery. Our objective is to contribute to barrier membrane studies that continue to guide and accelerate bone recovery.

Cited by 10 publications

References 24 publications

Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration

Novel non-resorbable polymeric-nanostructured scaffolds for guided bone regeneration

Horizontal Alveolar Ridge Augmentation in the Mandibular Posterior Region Using Biphasic Calcium Phosphate and Leukocyte- and Platelet rich fibrin (L-PRF): A case report.

Platelet-rich fibrin (PRF) membrane isolated and injectable-PRF-mixed particulate bovine bone graft in rattibiae non-critical defects healing

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