Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models

Kuki, Zsofia; Nagy, Katalin; Marko, Bernadett; Kompagne, Hajnalka; Lévay, György

doi:10.1016/j.bbr.2010.01.019

Cited by 12 publications

(12 citation statements)

References 51 publications

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“…The effects of 6-OHDA and 5,7-DHT microinjection into the prefrontal cortex on locomotor activity were similar to the previous studies (Li et al, 2010; Sziray et al, 2010; Wanchoo et al, 2010). Furthermore, the receptor antagonists did not affect the baseline locomotor activity, although Collins et al (2010) reported that the dopamine-D 1 receptor antagonist SCH39166 and the dopamine-D 2 receptor antagonist eticlopride decreased the locomotor activity in the open-field.…”

Section: Discussionsupporting

confidence: 89%

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice

Tanaka

Ago

Umehara

et al. 2016

IJNPPY

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Background:Isolation-reared mice show social encounter-induced hyperactivity with activation of prefrontal serotonergic and dopaminergic systems, but it is not known whether this stress response is observed in other pathological conditions. Here we examined whether the social encounter stimulation induces abnormal behavior during withdrawal in chronic methamphetamine-treated mice.Methods:To induce methamphetamine-induced behavioral sensitization, male mice were injected with methamphetamine (1 mg/kg) once daily for 7 days.Results:The encounter with an intruder elicited hyperactivity 24 h after the last injection of methamphetamine in methamphetamine-sensitized mice. This response was observed even as long as 2 weeks after withdrawal of methamphetamine. The encounter increased c-Fos expression in the prefrontal cortex, dorsal raphe nucleus and ventral tegmental area in methamphetamine-sensitized mice, while it did not in control mice. Furthermore, the encounter increased extracellular serotonin (5-HT) and dopamine, but not noradrenaline, levels in the prefrontal cortex in methamphetamine-sensitized mice. Local injection of 5,7-dihydroxytryptamine and 6-hydroxydopamine into the prefrontal cortex attenuated encounter-induced hyperactivity in methamphetamine-sensitized mice and it markedly decreased prefrontal 5-HT and dopamine levels, respectively. Pharmacological analysis showed that the encounter-induced hyperactivity is mediated by dopamine D1 receptors and 5-HT2A receptors and attenuated by anxiolytics and antidepressants such as diazepam, osemozotan and selective 5-HT reuptake inhibitors. The effect of paroxetine was blocked by the 5-HT3 receptor antagonist azasetron.Conclusions:The present study shows that psychological stress elicits hyperactivity with activation of prefrontal 5-HT and dopamine systems in methamphetamine-dependent mice and suggests that the abnormal behavior is associated with anxiety and depression.

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Section: Discussionsupporting

confidence: 89%

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice

Tanaka

Ago

Umehara

et al. 2016

IJNPPY

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“…The stimulation of the neurotransmitter release is accompanied by an activation of its synthesis, whereas the lack of stimulating effect by 5-HT on NE fibers dampens TH activity and thus NE synthesis. The interaction between serotonergic and noradrenergic systems have attracted attention as both systems are implicated in the control of a wide range of complex behaviors as well as the pathogenesis of affective disorders and their treatment by dual 5-HT/NE reuptake inhibitors (SNRI) [35]. Although moderate increase of brain NE content was observed in other Tph2−/− mice [20], the NE concentrations reported in [19] and [31] tend to be reduced but the difference did not reach significance.…”

Section: Discussionmentioning

confidence: 99%

Impacts of Brain Serotonin Deficiency following Tph2 Inactivation on Development and Raphe Neuron Serotonergic Specification

Gutknecht¹,

Araragi²,

Merker³

et al. 2012

PLoS ONE

101

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Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in developmental processes. Increasing evidence links 5-HT signaling alterations during development to emotional dysregulation and psychopathology in adult age. To further analyze the importance of brain 5-HT in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-HT deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (Tph2). Tph2 inactivation (Tph2−/−) resulted in brain 5-HT deficiency leading to growth retardation and persistent leanness, whereas a sex- and age-dependent increase in body weight was observed in Tph2+/− mice. The conserved expression pattern of the 5-HT neuron-specific markers (except Tph2 and 5-HT) demonstrates that brain 5-HT synthesis is not a prerequisite for the proliferation, differentiation and survival of raphe neurons subjected to the developmental program of serotonergic specification. Furthermore, although these neurons are unable to synthesize 5-HT from the precursor tryptophan, they still display electrophysiological properties characteristic of 5-HT neurons. Moreover, 5-HT deficiency induces an up-regulation of 5-HT1A and 5-HT1B receptors across brain regions as well as a reduction of norepinephrine concentrations accompanied by a reduced number of noradrenergic neurons. Together, our results characterize developmental, neurochemical, neurobiological and electrophysiological consequences of brain-specific 5-HT deficiency, reveal a dual dose-dependent role of 5-HT in body weight regulation and show that differentiation of serotonergic neuron phenotype is independent from endogenous 5-HT synthesis.

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“…Proper interaction as well as a fine-tuned balance between them is required for normal CNS functioning (Arias et al 2010;Sziray et al 2010). Unfortunately, these are the NTs for which there is less information concerning nAChR-regulated release.…”

Section: Functional Consequences Of Neurotransmitter Release After Namentioning

confidence: 99%

Prefrontal neuromodulation by nicotinic receptors for cognitive processes

Coura

Granon

2012

Psychopharmacology

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Effects of single and simultaneous lesions of serotonergic and noradrenergic pathways on open-space and bright-space anxiety-like behavior in two animal models

Cited by 12 publications

References 51 publications

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice

Role of prefrontal serotonergic and dopaminergic systems in encounter-induced hyperactivity in methamphetamine-sensitized mice

Impacts of Brain Serotonin Deficiency following Tph2 Inactivation on Development and Raphe Neuron Serotonergic Specification

Prefrontal neuromodulation by nicotinic receptors for cognitive processes

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