Effects of Statins on Oxidative Stress

Yılmaz, Mahmut İlker; Baykal, Yavuz; Kilic, Mahmut A.; Sönmez, Alper; Bulucu, Fatih; Aydın, Ahmet; Sayal, Ahmet; Kocar, Ismail H.

doi:10.1385/bter:98:2:119

Cited by 59 publications

(51 citation statements)

References 30 publications

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“…Recent clinical trials demonstrated that PPAR-␣ or PPAR-␥ agonist improved the outcome of atherosclerotic heart disease (10,14), whereas dual-PPAR agonist did not (34). In addition, statins improved insulin resistance (41) and antioxidant activities, including the restoration of Cu/ZnSOD activity (48), prevented the development of diabetes, reduced lipid levels (13,38), and improved clinical outcome in patients with hypercholesterolemia (1). These results, taken together with those of the present study, indicate that pitavastatin may selectively activate PPAR-␥ and Cu/ ZnSOD in hypercholesterolemia as pleiotropic effects.…”

Section: Discussionmentioning

confidence: 99%

“…These "pleiotropic effects" of statins include improvement of endothelial function, antithrombotic actions, plaque stabilization, reduction of the vascular inflammatory process, and an antioxidant function through the inhibition of NAD(P)H oxidase or the increase in SOD activity (3,6,26,32). Statins are also reported to improve insulin resistance (41) and antioxidant properties, including the restoration of Cu/ZnSOD activity (48), and prevent the development of diabetes in patients with hypercholesterolemia (13,38). Taken together, these observations allow one to assume that statins may have antiatherogenic actions through PPAR and Cu/ZnSOD activation, in addition to antidyslipidemic actions.…”

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confidence: 99%

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Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-γ, and aortic stiffness in hypercholesterolemia

Umeji

Umemoto

Itoh

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-γ, and aortic stiffness in hypercholesterolemia

Umeji

Umemoto

Itoh

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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“…The anti-inflammatory effect may also be related to decreased graft rejection via its immunomodulatory effects and the inhibition of factors that activate the inflammatory cascade (12) . The administration of fluvastatin in dyslipidemic patients induces reduced lipid levels and increased antioxidant protection by reducing the markers of oxidative injury (13) .…”

Section: Discussionmentioning

confidence: 99%

Sinvastatina e lesão renal aguda isquêmica em ratos

Teshima¹,

Watanabe²,

Fonseca³

et al. 2012

Acta paul. enferm.

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Objectives:The study aimed to verify the protective renal action of simvastatin in an animal model of ischemia / reperfusion for 30 minutes. Methods: Ischemia was obtained by clamping bilateral renal pedicles for 30 minutes, followed by reperfusion. Male Wistar rats were used, weighing between 250-300g, distributed into the following groups: SHAM (control, without clamping renal), Ischemia (renal ischemia for 30 minutes), Ischemia + Statin (simvastatin 0.5 mg/kg, orally for three days). Renal function (creatinine clearance, Jaffé method), urinary osmolality, and urinary peroxides were evaluated. Results: The results showed that the statin improved renal function, and reduced urinary osmolality along with excretion of PU. Conclusion: In summary, the study confirmed the protective renal effects of statins, with an antioxidant action that protects the kidney. Keywords: Acute kidney injury; Ischemia; Simvastatin/adverse effects; Rats RESUMOObjetivos: O estudo visou verificar a ação renoprotetora da sinvastatina em modelo animal de isquemia/reperfusão por 30 minutos. Métodos: A isquemia foi obtida por meio do clampeamento dos pedículos renais bilaterais por 30 minutos, seguida de reperfusão. Ratos Wistar, machos foram usados pesando entre 250-300g, distribuídos nos seguintes grupos: SHAM (controle, sem clampeamento renal); Isquemia (isquemia renal por 30 minutos); Isquemia+Estatina (sinvastatina 0,5 mg/kg, via oral durante três dias). A função renal (clearance de creatinina, método de Jaffé), a osmolalidade urinária, os peróxidos urinários foram avaliados. Resultados: Os resultados mostraram que a estatina melhorou a função renal, a osmolalidade urinária e reduziu a excreção de PU. Conclusão: Em síntese, o estudo confirmou o efeito renoprotetor da estatina, com ação antioxidante de proteção renal. Descritores: Lesão renal aguda; Isquemia; Sinvastatina/efeitos adversos; Ratos RESUMENObjetivos: El estudio tuvo como objetivo verificar la acción renoprotectora de la simvastatina en modelo animal de isquemia/reperfusión por 30 minutos. Métodos: La isquemia se obtuvo por medio del pinzamiento de los pedículos renales bilaterales por 30 minutos, seguida de la reperfusión. Fueron usadas ratas Wistar, machos que pesaban entre 250-300g, distribuidos en los siguientes grupos: SHAM (control, sin pinzamiento renal); Isquemia (isquemia renal por 30 minutos); Isquemia+Estatina (simvastatina 0,5 mg/kg, via oral durante tres días). Fueron evaluadas la función renal (clearance de creatinina, método de Jaffé), la osmolaridad urinaria y los peróxidos urinarios. Resultados: Los resultados mostraron que la estatina mejoró la función renal, la osmolaridad urinaria y redujo la excreción de PU. Conclusión: En síntesis, el estudio confirmó el efecto renoprotector de la estatina, con acción antioxidante de protección renal. Descriptores: Lesión renal aguda; Isquemia; Simvastatina/efectos adversos; Ratas

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“…Some studies have suggested statins protect the vascular endothelium from oxidative damage 182 Risk Factors for Age-related Macular Degeneration…”

Section: -181mentioning

confidence: 99%

Risk Factors for Age-related Macular Degeneration

Berrow¹,

Bartlett²,

Eperjesi³

et al. 2011

European Ophthalmic Review

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Age-related macular disease (ARMD) is a degenerative disease of the macula, most common over the age of 50 years.1 It is the leading cause of visual loss within western industrialised countries. [2][3][4] The number of blind registrations attributable to the disease increased by 30-40 % between 1950 and 1990 3 and the number of cases each year is continuing to rise 4-6 as these populations have an increasing longevity. Definition of Age-related Macular DiseaseThe international age-related maculopathy group has defined an international classification system for quantifying and defining the different subgroups of ARMD in an attempt to permit easier comparison of research findings between groups.1 Age-related maculopathy (ARM) is a disorder of the macular area most apparent after age 50 and is characterised by the following:• Areas of drusen which are external to the neuroretina and retinal pigment epithelium (RPE). They are soft and distinct or soft and indistinct. Hard drusen are not characteristic of ARM. Drusen are discrete white-yellow spots containing abnormal extracellular lipoprotein deposits that accumulate between the RPE basal lamina and the inner collagenous layer of Bruch's membrane. 7• Hyperpigmentation in the outer retina or choroid with drusen.• Hypopigmentation of the RPE with drusen.This early stage of the condition may not affect vision, but can predispose patients to visual loss (see Figure 1).Later stages of the condition are classified as 'wet' or 'dry' age-related macular degeneration (AMD). These forms of the disease can occur with or without the involvement of new blood vessel growth. If new vessels are not involved (dry AMD), clinical presentation is a sharply defined round or oval area of hypopigmentation where choroidal vessels are more visible than the surrounding area, with a diameter greater than 175 μm 1 (see Figure 2). This is also known as geographic atrophy (GA).The term 'wet AMD', also known as disciform AMD, exudative AMD or neovascular AMD refers to the development of choroidal neovascularisation (see Figure 3) and has numerous manifestations, including:• choroidal neovascularisation (CNV);• RPE detachment(s);• subretinal or sub-RPE neovascular membrane(s);• deposition of scarring, glial tissue or fibrin-like material within the epiretinal, intraretinal, subretinal or sub-RPE layers;• subretinal haemorrhages (without other retinal vascular cause); and• hard exudates (formed from lipid) associated with the above manifestations (without other retinal vascular cause).This article uses the terms ARM, AMD and ARMD as per the international classification system described. Physiology of Age-related Macular DiseaseThe RPE rests on Bruch's membrane and separates the neural retina from the choriocapillaris. The RPE phagocytoses the outer segment discs of the photoreceptors and is a point of metabolite and waste exchange, which is considered crucial to retinal function. 8 The initial signs of ARMD are variations within and below the RPE, seen as alterations in the pigmentation of the ...

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Effects of Statins on Oxidative Stress

Cited by 59 publications

References 30 publications

Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-γ, and aortic stiffness in hypercholesterolemia

Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-γ, and aortic stiffness in hypercholesterolemia

Sinvastatina e lesão renal aguda isquêmica em ratos

Risk Factors for Age-related Macular Degeneration

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