Effects of stimulus-driven synchronization on sensory perception

Tommerdahl, Mark; Tannan, Vinay; Zachek, Matt; Holden, Jameson K.; Favorov, Oleg V.

doi:10.1186/1744-9081-3-61

Cited by 43 publications

(66 citation statements)

References 53 publications

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“…Temporal order judgment synchronization impaired tactile performance in both controls and PD 'off' medication to similar degrees. The magnitude of the effect in controls is similar to a previous study 13 . Two-way ANOVA comparing PD 'on' medication versus controls revealed no significant effect of TASK (p=0.09), GROUP (p=0.58) or their interaction (p=0.27).…”

Section: Pd Versus Controlssupporting

confidence: 89%

“…The Cortical Metrics (CM) Device 13,22 was used to collect TOJ data. The right hand was supinated and positioned beneath the two contact probes of the CM device.…”

Section: Temporal Order Judgmentmentioning

confidence: 99%

“…The TOJ threshold for both tasks was defined as the average of the last five trials (i.e. trials 36 through 40) as used elsewhere 13,14 .…”

Section: Temporal Order Judgmentmentioning

confidence: 99%

“…In healthy individuals, TOJ may be selectively impaired by adding a weak synchronous vibrating stimulus in advance of the sequential test stimuli 13 . The perceptual impairment is thought to result from the synchronization of neural ensembles within primary somatosensory cortex (SI) that respond to two skin sites stimulated during TOJ.…”

mentioning

confidence: 99%

“…The perceptual impairment is thought to result from the synchronization of neural ensembles within primary somatosensory cortex (SI) that respond to two skin sites stimulated during TOJ. The co-activation of the two ensembles by the synchronous vibrating stimulus perceptually binds the two skin sites thereby making it difficult to identify the site that received the first stimulus within the TOJ pair 13,14 . The neural mechanism mediating the synchronization effect remains unclear although gamma-Aminobutyric acid (GABA)ergic inhibition occurring between SI mini-columns, the smallest unit of columnar organization within the neocortex consisting of 80-100 neurons that span layers II-VI 15 , is a likely candidate and is important for preserving temporal acuity for optimal sensorimotor control.…”

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confidence: 99%

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Dopamine Alters Tactile Perception in Parkinson's Disease

Nelson

Premji²,

Rai³

et al. 2012

Can. J. Neurol. Sci.

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. Contexte : Le traitement anormal de l'information somatosensitive pourrait contribuer à l'altération de la motricité observée dans la maladie de Parkinson (MP). Il a été démontré que les médicaments dopaminergiques modifient le traitement de l'information somatosensitive de telle sorte que la perception tactile en est améliorée. Dans la MP, nous ne savons pas si la séquence temporelle des stimuli tactiles est modifiée et si les médicaments dopaminergiques modifient cette perception. Méthode : La perception tactile somatosensitive a été étudiée au moyen du test de discernement de l'ordre de succession de stimuli chez des patients atteints de la MP avec et sans effet de la médication dopaminergique et chez des témoins en bonne santé appariés pour l'âge. L'évaluation du discernement de l'ordre temporel de stimuli a été effectuée au moyen de la stimulation contrôlée par ordinateur des 2e et 3e doigts de la main droite. Les sujets devaient déterminer quel stimulus était appliqué le premier. Deux tâches expérimentales ont été comparées : le discernement de l'ordre temporel sans et avec synchronisation, soit l'application au préalable d'une vibration synchrone aux les 2e et 3e doigts. Résultats : Le discernement de l'ordre temporel chez les patients atteints de la MP sans et avec l'effet des médicaments était semblable à celui des témoins. Lorsque le test de discernement de l'ordre temporel était précédé par les vibrations synchrones, l'acuité tactile chez les témoins et les patients sans l'effet de la médication était perturbée à des degrés semblables, mais cette perturbation perceptuelle due aux vibrations synchrones n'était pas présente chez les patients sous l'effet de la médication. Conclusions : Ces constatations suggèrent que, chez les patients atteints de la MP, la dopamine diminue la connectivité cortico-corticale dans l'aire somatosensitive SI, ce qui provoque des changements dans la sensibilité tactile.

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Section: Pd Versus Controlssupporting

confidence: 89%

“…The Cortical Metrics (CM) Device 13,22 was used to collect TOJ data. The right hand was supinated and positioned beneath the two contact probes of the CM device.…”

Section: Temporal Order Judgmentmentioning

confidence: 99%

“…The TOJ threshold for both tasks was defined as the average of the last five trials (i.e. trials 36 through 40) as used elsewhere 13,14 .…”

Section: Temporal Order Judgmentmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Dopamine Alters Tactile Perception in Parkinson's Disease

Nelson

Premji²,

Rai³

et al. 2012

Can. J. Neurol. Sci.

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Somatosensory Temporal Discrimination in Autism Spectrum Disorder

et al. 2021

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Sensory differences are common in Autism Spectrum Disorder (ASD). While there is no well‐accepted method to measure sensory differences objectively, there is accumulating evidence from recent years concerning sensory perception, including data concerning temporal discrimination thresholds of individuals with ASD as measured by different measures. The somatosensory temporal discrimination (STD) test measures the threshold at which an individual can temporally discriminate multiple tactile stimuli delivered in succession. We aimed to investigate tactile perception in ASD and hypothesized that children with ASD have impaired STD related to their subjective sensory symptoms and daily difficulties. Thirty adolescents with ASD and 30 typically developed subjects were recruited. The Childhood Autism Rating Scale, Strengths and Difficulties Questionnaire, and Adolescent/Adult Sensory Profile were implemented before STD evaluation. Average somatosensory detection (1.48 ± 0.42) and discrimination thresholds (112.70 ± 43.45) of the children with ASD were significantly higher (P = 0.010, P = 0.001, respectively) than those of the controls (1.18 ± 0.42, 79.95 ± 31.60, respectively). Sensory seeking scores of the ASD group (40.8 ± 7.60) were significantly lower (P = 0.024) than those of the control group (45.83 ± 9.17). However, the psychophsycal thresholds did not have any statistically significant relationships with subjective sensory symptoms or daily difficulties. This study demonstrates impaired sensory processing in ASD evaluated by STD and its lack of relationship with subjective sensory symptoms and daily difficulties. This psychophysical evidence of increased STD thresholds and decreased sensory seeking profile supports the disturbances in the regulation of sensory processing in ASD. Lay Summary Sensory differences are common in autism; however, there is no well‐accepted method to measure them objectively. This study aims to investigate somatosensory differences and their relation with sensory and emotional/behavioral difficulties of children with autism. We show that autistic children have higher tactile discrimination thresholds and fewer sensory seeking behaviors. This supports the presence of impairments in sensory processing in autism. Measuring the sensory differences may help understanding clinical symptoms and neurobiological underpinings of autism. Autism Res 2021, 14: 656–667. © 2021 International Society for Autism Research and Wiley Periodicals LLC

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Perceptual metrics of individuals with autism provide evidence for disinhibition

et al. 2008

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Adults with autism exhibit inhibitory deficits that are often manifested in behavioral modifications, such as repetitive behaviors, and/or sensory hyper-responsiveness. If such behaviors are the result of a generalized deficiency in inhibitory neurotransmission, then it stands to reason that deficits involving localized cortical-cortical interactions – such as in sensory discrimination tasks – could be detected and quantified. This study exemplifies a newly developed method for quantifying sensory testing metrics. Our novel sensory discrimination tests may provide (a) an effective means for biobehavioral assessment of deficits specific to autism and (b) an efficient and sensitive measure of change following treatment. The sensory discriminative capacity of 10 subjects with autism and 10 controls was compared both before and after short duration adapting stimuli. Specifically, vibrotactile amplitude discriminative capacity was obtained both in the presence and absence of 1 sec adapting stimuli that were delivered 1 sec prior to the comparison stimuli. Although adaptation had a pronounced effect on the amplitude discriminative capacity of the control subjects, little or no impact was observed on the sensory discriminative capacity of the subjects with autism. This lack of impact of the adapting stimuli on the responses of the subjects with autism was interpreted to be consistent with the reduced GABAergic mediated inhibition described in previous reports. One significant aspect of this study is that the methods could prove to be a useful and efficient way to detect specific neural deficits and monitor the efficacy of pharmacological or behavioral treatments in autism.

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Effects of stimulus-driven synchronization on sensory perception

Cited by 43 publications

References 53 publications

Dopamine Alters Tactile Perception in Parkinson's Disease

Dopamine Alters Tactile Perception in Parkinson's Disease

Somatosensory Temporal Discrimination in Autism Spectrum Disorder

Perceptual metrics of individuals with autism provide evidence for disinhibition

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