Effects of suramin on hormone release by cultured rat anterior pituitary cells

Marzouk, H.; Hofland, Leo J.; Holder, F. H. Den; Koetsveld, Peter M. van; Steenbergen, Jacobie; Zuiderwijk, J.; Abou-Hashim, E. M.; El-Kannishy, Mohammed H.; Jong, Frank H. de; Lamberts, Steven W. J.

doi:10.1016/0303-7207(90)90099-t

Cited by 10 publications

(1 citation statement)

References 22 publications

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“…The tissues were minced into small pieces and single cell suspensions of both tissues were prepared by enzymatic dissociation using collagenase, as described in detail elsewhere (8). Subsequently, the cells were resuspended in Dulbecco's modified Eagle's medium (DMEM) þ 1% FCS.…”

Section: In Vitro Studiesmentioning

confidence: 99%

Sequential ACTH and catecholamine secretion in a phaeochromocytoma

Dam

Gils

Dijk

et al. 2002

European Journal of Endocrinology

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Objective: We describe a patient with an ACTH-producing phaeochromocytoma who initially presented with hypercortisolism and normal catecholamine concentrations, followed by near-normalisation of ACTH secretion and massive catecholamine secretion. In vitro studies were carried out on the tumour to evaluate the interaction between the tumour cells and normal adrenal cortex. Methods and Results: A 30-year-old man initially presented with severe hypercortisolism, biochemical evidence of ectopic ACTH production, a tumour in the right adrenal gland without a hyperintense signal on the T2-weighted images at magnetic resonance imaging (MRI) scanning, and normal urinary metanephrine concentrations. After 6 months, ACTH production had almost completely resolved, but the patient developed severe hypertension and excess catecholamines. At repeated MRI-scanning, the T2-weighted images showed a hyperintense signal, in agreement with the diagnosis of phaeochromocytoma. Although the initial T1-weighted images suggested bleeding in the adrenal tumour, no signs of bleeding were observed after surgical removal. The diagnosis of ACTH-producing phaeochromocytoma was histologically and immunohistochemically confirmed. Cultured cell suspensions of the tumour secreted ACTH, which stimulated cortisol production in the ipsilateral adrenocortical cells. Conclusion: This case demonstrates that the biological activity of an ACTH-producing phaeochromocytoma can vary significantly in time, which may be the consequence of different stages of tumour differentiation.

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Section: In Vitro Studiesmentioning

confidence: 99%

Sequential ACTH and catecholamine secretion in a phaeochromocytoma

Dam

Gils

Dijk

et al. 2002

European Journal of Endocrinology

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Mineralocorticoid insufficiency due to suramin therapy

Kobayashi

Weiss

Vogelzang

et al. 1996

Cancer

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The experience with suramin in advanced prostate cancer

Eisenberger

Reyno

Sinibaldi

et al. 1995

Cancer

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Suramin is a new experimental polyanionic compound that has shown evidence of antitumor activity in patients with hormone refractory prostate cancer. After a few years of Phase I and Phase II testing, much of the drug's toxicity pattern has been carefully characterized. Similarly, pharmacologic studies have defined many of the drug's complex pharmacologic properties to the extent that simple outpatient methods of drug administration can be easily accomplished. A pharmacologically derived, fixed outpatient schedule has been shown to be safe and effective and is currently in active Phase III development in prostate cancer and will provide more definitive data regarding the role of suramin in the treatment of this disease. Despite these accomplishments, a number of questions require further study, such as definition of pharmacodynamic correlations, effects on the hypothalamic‐pituitary‐adrenal and gonadal axis, and the nature of its most common dose‐limiting toxicity, which is a syndrome of malaise and fatigue. Cancer 1995;75:1927–34.

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Effects of suramin on hormone release by cultured rat anterior pituitary cells

Cited by 10 publications

References 22 publications

Sequential ACTH and catecholamine secretion in a phaeochromocytoma

Sequential ACTH and catecholamine secretion in a phaeochromocytoma

Mineralocorticoid insufficiency due to suramin therapy

The experience with suramin in advanced prostate cancer

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