Effects of Teucrium spp.: Extracts on migratory potential and redox status of human colon SW-480 and breast MDA-MB-231 cancer cells

Abstract

), nitrites and reduced glutathione (GSH), determined spectrophotometrically, while migratory potential of cancer cells was followed by real time cell analysis. Our results showed acute increasing of superoxide anion radical, decreasing of nitrites and decreasing of GSH in SW-480 cells. In MDA-MB-231 cells investigated extracts showed no change in GSH level. Also, methanol extract of T. montanum in low concentrations decreased cell migration, while T. polium showed antimigratory potential in higher concentrations and in treatment periods longer than 12 hours. Investigated Teucrium spp. extracts showed changes in redox status leading to enhancement of oxidative stress. Also, results indicated moderate reducing of migratory potential of tested cancer cells. However, correlation between redox status and antimigratory effects were not observed. According to these findings, the additional investigation of the exact mechanism of antimigratory effect should be performed.

Teucrium montanum extract drives effector and memory differentiation of CD8+ T cells

“…For these reasons, it is considered to be a viable therapeutic option for various kinds of ailments and disorders, including cardiovascular disease, neurodegenerative disease, intestinal spasms, diarrhea, rheumatoid arthritis, inflammatory bowel disease, diabetes, and hyperlipidemia 9-11 . T. montanum acts as a healing herb and is capable of protecting from microbial infection, cirrhosis, and cancer, particularly in the respiratory and digestive tracts 1,12- 15 . Notably, it has demonstrated strong antiproliferative activity, inducing early apoptosis of tumor cells as opposed to promoting apoptosis in the late stage as in the case of T. polium, for example 2 .…”