Effects of the extraction method and chromatographic separation solvent in the antioxidant activity of different species of “espinheira-santa”

Chiapetti, Tatiane Priscila; Malavasi, Ubirajara Contro; Braga, Gilberto Costa; Malavasì, Marlene de Matos

doi:10.1007/s13197-019-03978-1

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…include terpenes (maytin, tringenone, isotenginone II, congorosins A and B, maitenoic acid), triterpenes (friedelanol and friedelin), essential oils (friedenelol), tannins, especially galics (epicatechin, epigallocatechin, and gallate of epigallocatechin), glycol monogalactosyldiacylglycerol, digalactosyldiacylglycerol, trigalactosyldiacylglycerol, tetragalactosyldiacylglycerol and sulphoquinovosyldiacylglycerol) and, lastly, alkaloids (maitein, maytinprine and maytol). [8][9][10][11][12] While Chiapetti et al 13…”

Section: Introductionmentioning

confidence: 99%

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

Paulino¹,

Vieira²,

Braga³

et al. 2019

Int J Phytocos Nat Ingred

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Brazil is the country with the biggest biodiversity on the planet, but it does not avail itself enough of this potential to produce herbal medicines. Maytenus ilicifolia Mart. Ex Reissek is popularly known as "Espinheira-Santa" and in Brazil is widely used in popular medicine to treat a number of diseases such as gastritis and dyspepsia, and also displays laxative, diuretic, analgesic, antiseptic and healing properties and antineoplastic and antimicrobial activities. Among the reasons that hinder a better exploration of such biodiversity, the absence of an innovative culture draws a lot of attention, besides the inherent difficulties in the characteristics of the research and the development of this product modality. The aim of this study was developing an effervescent powder containing medicinal extract of M. ilicifolia. The methodologies to determine quality of the plant and extract including the organoleptic characteristics, the moisture content and volatiles, total ashes, extractive content, pH, and the bulk density. In our experiments, we demonstrated that the plant has been identified and has displayed the appropriate organoleptic characteristics to the preparation of the extract; we also demonstrated that the extract has been incorporated into a formulation that maintained its organoleptic characteristics, pH and content, as well as the formation of stable gases. With these experiments, we demonstrate for the first time that the developed formulation can serve as a prototype for the development of pharmaceutics effervescent product containing standardized extract of M. ilicifolia.

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Section: Introductionmentioning

confidence: 99%

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

Paulino¹,

Vieira²,

Braga³

et al. 2019

Int J Phytocos Nat Ingred

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Improved extraction of bioactive compounds from Monteverdia aquifolia leaves by pressurized-liquid and ultrasound-assisted extraction: Yield and chemical composition

Alves

Triques

Palsikowski

et al. 2022

The Journal of Supercritical Fluids

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In vitro antioxidant, anticancer and in silico studies of polyphenol enriched leaf extract of Asystasia gangetica

Dilkalal,

Annapurna,

Umesh

2024

Sci Rep

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Polyphenols are natural biomolecules known for circumventing several diseases including cancer with little adverse effects. This study aimed to investigate the polyphenol enriched fractions from the leaf extract of Asystasia gangetica for their composition, biological activities such as antioxidant activity, haemolytic effects, and in vitro cytotoxicity against cancer cell lines. LC–MS/MS analysis of the enriched fractions identified a total of 35 distinct polyphenols with caffeic acid, luteolin, apigenin, and protocatechuic acid at higher concentrations. Fractions AG-3 and AG-4 exhibited the highest total antioxidant activity with higher concentration of phenolics and flavonoids. The AG-4 fraction had the highest levels of DPPH radical scavenging (IC 50 = 32.74 µg mL -1 ) and ABTS radical scavenging (IC 50 = 29.45 µg mL –1 ) activity, in addition to a modest iron chelating activity and reducing power. The fractions exhibited the least haemolytic activity. The cytotoxic potential of enriched fractions against the HCT-116, HeLa, PC-3, and HDF cell lines was further examined. While the extract showed no inhibitory effect on normal HDF cells, the cytotoxic activity of fractions on cell lines varied, with HCT-116 cells having the strongest anticancer activity with an IC 50 of 43.82 µg mL –1 . Additionally, fractions induced apoptotic activity in HCT-116 cells, resulting in cell cycle arrest at the G 2 M phase and an increase in sub-G0/G1 cells, with an IC 50 of 13.54 µg mL –1 after 48 h of incubation. The in silico molecular docking of the active compounds against the TNIK receptor protein and ADMET (Absorption–Distribution–Metabolism–Excretion–Toxicity) characteristics are described. Overall, the study highlights the enhanced biological and antiproliferative activities of polyphenols in Asystasia gangetica leaf extract, which could be further utilized as a potential cancer treatment strategy.

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Effects of the extraction method and chromatographic separation solvent in the antioxidant activity of different species of “espinheira-santa”

Cited by 4 publications

References 12 publications

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

Development of effervescent medical powder containing Maytenus ilicifolia extract Mart. ex Reissek for treatment of gastric disorders

Improved extraction of bioactive compounds from Monteverdia aquifolia leaves by pressurized-liquid and ultrasound-assisted extraction: Yield and chemical composition

In vitro antioxidant, anticancer and in silico studies of polyphenol enriched leaf extract of Asystasia gangetica

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