Effects of the interactions between platelets with other cells in tumor growth and progression

Li, Yaxin; Wang, Haiyan; Zhao, Zhen Zhao; Yang, Yuanming; Meng, Zifan; Qin, Lifeng

doi:10.3389/fimmu.2023.1165989

Cited by 12 publications

(8 citation statements)

References 298 publications

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“…Activated platelets secrete vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF). VEGF is an inducer of angiogenesis or new vessel formation, a mechanism adopted by tumor cells to promote growth and tumor neovascularization [ 32 ]. The platelet-derived growth factor (PDGF) signaling pathway plays a pivotal role in the progression of pancreatic cancer [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Pancreatic Cancer and Venous Thromboembolism

Prouse,

Mohammad,

Ghosh

et al. 2024

IJMS

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Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of all pancreatic cancers and is the most fatal of all cancers. The treatment response from combination chemotherapies is far from satisfactory and surgery remains the mainstay of curative strategies. These challenges warrant identifying effective treatments for combating this deadly cancer. PDAC tumor progression is associated with the robust activation of the coagulation system. Notably, cancer-associated thrombosis (CAT) is a significant risk factor in PDAC. CAT is a concept whereby cancer cells promote thromboembolism, primarily venous thromboembolism (VTE). Of all cancer types, PDAC is associated with the highest risk of developing VTE. Hypoxia in a PDAC tumor microenvironment also elevates thrombotic risk. Direct oral anticoagulants (DOACs) or low-molecular-weight heparin (LMWH) are used only as thromboprophylaxis in PDAC. However, a precision medicine approach is recommended to determine the precise dose and duration of thromboprophylaxis in clinical setting.

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Section: Resultsmentioning

confidence: 99%

Pancreatic Cancer and Venous Thromboembolism

Prouse,

Mohammad,

Ghosh

et al. 2024

IJMS

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“… 25 , 26 By contrast, the remaining two types of monocytes differentiate into M2 macrophages, which contribute to promote tumor‐promoting and immunosuppressive effects. 27 In addition, the distribution of the subpopulation composition of monocytes is altered in different malignant cancer diseases. 28 The mutual conversion of different subgroups had been demonstrated to have a promising predictive value for the prognosis of tumor patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of preoperative combined neutrophil, monocyte, and lymphocyte scores in patients with renal cell carcinoma undergoing laparoscopic nephrectomy: A retrospective study

Ni,

Yao,

Song

et al. 2024

Cancer Medicine

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BackgroundIn a multi‐institutional clinical study, we assessed the prognostic significance of a novel indicator preoperative peripheral blood immune (PBIS) scores that combined ratios of preoperative lymphocyte, monocyte, and neutrophil of renal cell carcinoma (RCC) patients undergoing laparoscopic nephrectomy.MethodsBetween January 2014 and December 2019, 438 patients with RCC were retrospectively analyzed in three centers. We used X‐tile software to obtain the optimum cut‐off values for neutrophils, monocytes, and lymphocytes to classify the patients. To assess the relationship between PBIS score and overall survival (OS), and cancer‐specific survival (CSS) in patients with RCC by Kaplan–Meier survival curves and Cox regression analyses. In addition, predictive OS and CSS nomograms were constructed. The discriminative ability of nomogram and predictive performance accuracy were verified with consistency index (C‐index), calibration curves, receiver operating curve (ROC) curves, decision curve analysis (DCA) curves, and time‐dependent ROC curves.ResultsThe optimum cutoff values for monocytes, lymphocytes, and neutrophils were 0.46, 1.01, and 4.50, respectively. We divided patients into four subgroups according to PBIS scores, which were significantly associated with M‐stage (p = 0.008), T‐stage (p < 0.001), N‐stage (p = 0.006), and AJCC stage (p < 0.001). Multivariate Cox regression analysis revealed that RCC patients with lower PBIS scores showed a worse postoperative prognosis and served as an independent predictor of OS (p = 0.002) and CSS (p < 0.001). Ultimately, the nomograms based on PBIS scores demonstrated excellent predictive performance for OS (C‐index: 0.770) and CSS (C‐index: 0.828) through the analysis of calibration curves, ROC curves, DCA curves, and time‐dependent ROC curves.ConclusionPBIS score served as novel and effective predictor to accurately predict OS and CSS in patients with RCC receiving laparoscopic nephrectomy.

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“…In the latest bioinformatic analysis involving 2,994 patients, TNBC with less genetic NLR were enriched in several immunity-related gene sets; TNBC carrying lower NLR might benefit from ICIs [ 18 ]. Tumor derived platelets recruit hemocyte and immune cells for migration and established inflammatory tumor microenvironment at primary and metastatic sites [ 19 ]. Inflammatory environment via high NLR impaired the clinical efficacy of ICIs and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Circulating blood biomarkers correlated with the prognosis of advanced triple negative breast cancer

Li,

Zhang,

Zhu

et al. 2024

BMC Women's Health

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Background Immune checkpoint inhibitors (ICIs) can improve survivals of metastatic triple negative breast cancer (mTNBC); however, we still seek circulating blood biomarkers to predict the efficacy of ICIs. Materials and methods In this study, we analyzed the data of ICIs treated mTNBC collected in Anhui Medical University affiliated hospitals from 2018 to 2023. The counts of lymphocytes, monocytes, platelets, and ratio indexes (NLR, MLR, PLR) in peripheral blood were investigated via the Kaplan-Meier curves and the Cox proportional-hazards model. Results The total of 50 mTNBC patients were treated with ICIs. High level of peripheral lymphocytes and low level of NLR and MLR at baseline and post the first cycle of ICIs play the predictable role of immunotherapies. Lymphocytes counts (HR = 0.280; 95% CI: 0.095–0.823; p = 0.021) and NLR (HR = 1.150; 95% CI: 1.052–1.257; p = 0.002) are significantly correlated with overall survival. High NLR also increases the risk of disease progression (HR = 2.189; 95% CI:1.085–4.414; p = 0.029). When NLR at baseline ≥ 2.75, the hazard of death (HR = 2.575; 95% CI:1.217–5.447; p = 0.013) and disease progression (HR = 2.189; 95% CI: 1.085–4.414; p = 0.029) significantly rise. HER-2 expression and anti-tumor therapy lines are statistically correlated with survivals. Conclusions Before the initiation of ICIs, enriched peripheral lymphocytes and poor neutrophils and NLR contribute to the prediction of survivals.

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Effects of the interactions between platelets with other cells in tumor growth and progression

Cited by 12 publications

References 298 publications

Pancreatic Cancer and Venous Thromboembolism

Pancreatic Cancer and Venous Thromboembolism

Prognostic value of preoperative combined neutrophil, monocyte, and lymphocyte scores in patients with renal cell carcinoma undergoing laparoscopic nephrectomy: A retrospective study

Circulating blood biomarkers correlated with the prognosis of advanced triple negative breast cancer

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