Effects of the surface morphologies of ZnO nanotube arrays on the performance of amperometric glucose sensors

Fan, Zhongwei; Jing, Weixuan; Wu, Qiong; Gao, Weizhuo; Jiang, Zhuangde; Shi, Jiafan; Cui, Q. B.

doi:10.1016/j.mssp.2016.08.009

Cited by 32 publications

(17 citation statements)

References 31 publications

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“…This result was comparable with that of Zhao et al . 41 , who also indicated 42 good affinity of GOx immobilisation onto ZnO nanorods surface even when simple physical adsorption was used.…”

Section: Resultsmentioning

confidence: 98%

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Fabrication and Characterization of Glucose Biosensors by Using Hydrothermally Grown ZnO Nanorods

Ridhuan

Razak

Lockman

2018

Sci Rep

116

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Highly oriented ZnO nanorod (NR) arrays were fabricated on a seeded substrate through a hydrothermal route. The prepared ZnO nanorods were used as an amperometric enzyme electrode, in which glucose oxidase (GOx) was immobilised through physical adsorption. The modified electrode was designated as Nafion/GOx/ZnO NRs/ITO. The morphology and structural properties of the fabricated ZnO nanorods were analysed using field-emission scanning electron microscope and X-ray diffractometer. The electrochemical properties of the fabricated biosensor were studied by cyclic voltammetry and amperometry. Electrolyte pH, electrolyte temperature and enzyme concentration used for immobilisation were the examined parameters influencing enzyme activity and biosensor performance. The immobilised enzyme electrode showed good GOx retention activity. The amount of electroactive GOx was 7.82 × 10−8 mol/cm2, which was relatively higher than previously reported values. The Nafion/GOx/ZnO NRs/ITO electrode also displayed a linear response to glucose ranging from 0.05 mM to 1 mM, with a sensitivity of 48.75 µA/mM and a low Michaelis–Menten constant of 0.34 mM. Thus, the modified electrode can be used as a highly sensitive third-generation glucose biosensor with high resistance against interfering species, such as ascorbic acid, uric acid and L-cysteine. The applicability of the modified electrode was tested using human blood samples. Results were comparable with those obtained using a standard glucometer, indicating the excellent performance of the modified electrode.

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Section: Resultsmentioning

confidence: 98%

“…Meanwhile, Zhou et al . 42 reported a stability of 80.8% of its original current response in glucose after 10 days for ZnO NTs formed through the selective dissolution of ZnO NRs which were hydrothermally grown on Au cylindrical spiral electrode. This result was comparable with that of Zhao et al .…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Characterization of Glucose Biosensors by Using Hydrothermally Grown ZnO Nanorods

Ridhuan

Razak

Lockman

2018

Sci Rep

116

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“…According to the surface heights, the characteristic parameters including roughness Ra, skewness Sk, kurtosis Ku, and correlation length ξ were determined, and the surface morphologies of the ZnO and ZnO-Ag nanorods were characterized. The detailed calculation of the characteristic parameters is available in our previous work [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Doping Ag in ZnO Nanorods to Improve the Performance of Related Enzymatic Glucose Sensors

Fan

Jing

Liu

et al. 2017

Sensors

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In this paper, the performance of a zinc oxide (ZnO) nanorod-based enzymatic glucose sensor was enhanced with silver (Ag)-doped ZnO (ZnO-Ag) nanorods. The effect of the doped Ag on the surface morphologies, wettability, and electron transfer capability of the ZnO-Ag nanorods, as well as the catalytic character of glucose oxidase (GOx) and the performance of the glucose sensor was investigated. The results indicate that the doped Ag slightly weakens the surface roughness and hydrophilicity of the ZnO-Ag nanorods, but remarkably increases their electron transfer ability and enhances the catalytic character of GOx. Consequently, the combined effects of the above influencing factors lead to a notable improvement of the performance of the glucose sensor, that is, the sensitivity increases and the detection limit decreases. The optimal amount of the doped Ag is determined to be 2 mM, and the corresponding glucose sensor exhibits a sensitivity of 3.85 μA/(mM·cm2), detection limit of 1.5 μM, linear range of 1.5 × 10−3–6.5 mM, and Michaelis-Menten constant of 3.87 mM. Moreover, the glucose sensor shows excellent selectivity to urea, ascorbic acid, and uric acid, in addition to displaying good storage stability. These results demonstrate that ZnO-Ag nanorods are promising matrix materials for the construction of other enzymatic biosensors.

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“…A high value of IEP allows a better absorption process of enzymes, DNA, and proteins by electrostatic interactions [7]. ZnO has been used widely to detect various species such as glucose [8], cholesterol [7], uric acid [9], Leptospira [10], ascorbic acid [11], and cancer cells [12].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical-Based Biosensors on Different Zinc Oxide Nanostructures: A Review

et al. 2019

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Electrochemical biosensors have shown great potential in the medical diagnosis field. The performance of electrochemical biosensors depends on the sensing materials used. ZnO nanostructures play important roles as the active sites where biological events occur, subsequently defining the sensitivity and stability of the device. ZnO nanostructures have been synthesized into four different dimensional formations, which are zero dimensional (nanoparticles and quantum dots), one dimensional (nanorods, nanotubes, nanofibers, and nanowires), two dimensional (nanosheets, nanoflakes, nanodiscs, and nanowalls) and three dimensional (hollow spheres and nanoflowers). The zero-dimensional nanostructures could be utilized for creating more active sites with a larger surface area. Meanwhile, one-dimensional nanostructures provide a direct and stable pathway for rapid electron transport. Two-dimensional nanostructures possess a unique polar surface for enhancing the immobilization process. Finally, three-dimensional nanostructures create extra surface area because of their geometric volume. The sensing performance of each of these morphologies toward the bio-analyte level makes ZnO nanostructures a suitable candidate to be applied as active sites in electrochemical biosensors for medical diagnostic purposes. This review highlights recent advances in various dimensions of ZnO nanostructures towards electrochemical biosensor applications.

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Effects of the surface morphologies of ZnO nanotube arrays on the performance of amperometric glucose sensors

Cited by 32 publications

References 31 publications

Fabrication and Characterization of Glucose Biosensors by Using Hydrothermally Grown ZnO Nanorods

Fabrication and Characterization of Glucose Biosensors by Using Hydrothermally Grown ZnO Nanorods

Doping Ag in ZnO Nanorods to Improve the Performance of Related Enzymatic Glucose Sensors

Electrochemical-Based Biosensors on Different Zinc Oxide Nanostructures: A Review

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