Effects of Three Different Testosterone Formulations in Female-to-Male Transsexual Persons

Pelusi, Carla; Costantino, Antonietta; Martelli, Valentina; Lambertini, Martina; Bazzocchi, Alberto; Ponti, Federico; Battista, Giuseppe; Venturoli, Stefano; Meriggiola, Maria Cristina

doi:10.1111/jsm.12698

Cited by 149 publications

(153 citation statements)

References 40 publications

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“…Several studies note an increase in BMI for FtM patients after initiation of hormone therapy [9], [12], [13], [14]. Similarly, our study also saw an increase in BMI at Visit 1 in the FtM cohort, possibly due to increased muscle mass.…”

Section: 0 Discussionsupporting

confidence: 81%

“…Additionally, the FtM cohort showed an increase in creatinine at both Visit 1 and Visit 2; this would be an expected change if the FtM cohort had an average increase in muscle mass and thus muscle break-down products – a possibility given the observed increase in BMI. Testosterone use in hormone therapy for transgender men is associated with an increase in hemoglobin and hematocrit [11], [12], [13] [14], [15]. Our study also observed an increase in the hemogram parameters for the FtM cohort at Visit 1 and Visit 2.…”

Section: 0 Discussionsupporting

confidence: 60%

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Metabolic Effects Of Hormone Therapy In Transgender Patients

Fernandez

Tannock

2016

Endocrine Practice

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Objective Transgender patients may seek hormone therapy to induce physical changes to simulate their expressed or experienced gender. However, many providers are uncomfortable prescribing transgender hormones due to fears over safety. The goal of this study was to determine if transgender hormone therapy with estrogen and spironolactone for male-to-female (MtF) patients or with testosterone for female-to-male (FtM) patients had adverse anthropomorphic or metabolic effects. Methods This retrospective chart review study analyzed changes over time for 33 MtF and 19 FtM endocrine clinic patients at an academic endocrine practice with follow up for up to 18 months after hormone initiation. Results Compared to baseline labs obtained prior to initiation of hormone therapy statistically significant changes for the MtF cohort included an increase in HDL and decrease in creatinine; however, triglycerides did not show a statistically significant change. In the FtM cohort, there was a statistically significant increase in body mass index, creatinine, hemoglobin, and hematocrit. These changes were minimal for both cohorts. Conclusion In our practice, hormone therapy was found to be safe in this retrospective study.

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Section: 0 Discussionsupporting

confidence: 81%

Section: 0 Discussionsupporting

confidence: 60%

Metabolic Effects Of Hormone Therapy In Transgender Patients

Fernandez

Tannock

2016

Endocrine Practice

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“…Similar studies of testosterone therapy in transgender men report decreases in HDL cholesterol, increases in triglycerides and either no change or increase in LDL cholesterol [30,31,33,34]. Cross-sectional studies, retrospective cohort studies, and a systematic literature review all have similar findings [21,26,32,35].…”

Section: Research To Datementioning

confidence: 71%

“…Small prospective studies exist which examine time to menstrual cessation with testosterone therapy [31,33]. Outcomes research on other transition related interventions, including speech therapy, are scattered throughout the literature [51,52,53].…”

Section: Research To Datementioning

confidence: 99%

Priorities for transgender medical and healthcare research

Feldman

Brown

Deutsch

et al. 2016

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

124

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Purpose of Review Transgender individuals experience unique health disparities but are the subject of little focused health research. This manuscript reviews current literature on transgender medical and mental health outcomes and proposes research priorities to address knowledge gaps. Recent Findings Published research in transgender health care consists primarily of case reports, retrospective and cross-sectional studies, involving largely European settings. Challenges to US-based transgender health research include a diverse population where no single center has sufficient patient base to conduct clinical research with statistical rigor. Treatment regimens are heterogeneous and warrant study for best practices. Current research suggests increased mortality and depression in transgender individuals not receiving optimal care, and possibly a modest increase in cardiovascular risk related to hormone therapy. Current evidence does not support concerns for hormone related malignancy risk. Summary The priorities for transgender medical outcomes research should be to determine health disparities and co-morbid health conditions over the life span, along with the effects of mental health, medical, and surgical interventions on morbidity and mortality. Specific outcomes of interest based on frequency in the literature, potential severity of outcome, and patient-centered interest, include affective disorders, cardiovascular disease, malignancies, fertility, and time-dose related responses of specific interventions.

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“…The role of DXA is central in the study of body composition (BC) thanks to its ability to differentiate FM, non-bone lean mass (LM) and BMC at both the regional and the whole-body level ( Figure 2) (49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60). DXA relies on the use of two X-ray beams of different energy; the measurement of the "R value" is calculated as the ratio between the degree of attenuation of the lower energy and the higher energy beam.…”

Section: Dxamentioning

confidence: 99%

Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia

Guerri

Mercatelli

Gómez

et al. 2018

Quant. Imaging Med. Surg.

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117

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Bone and muscle are two deeply interconnected organs and a strong relationship between them exists in their development and maintenance. The peak of both bone and muscle mass is achieved in early adulthood, followed by a progressive decline after the age of 40. The increase in life expectancy in developed countries resulted in an increase of degenerative diseases affecting the musculoskeletal system. Osteoporosis and sarcopenia represent a major cause of morbidity and mortality in the elderly population and are associated with a significant increase in healthcare costs. Several imaging techniques are currently available for the non-invasive investigation of bone and muscle mass and quality. Conventional radiology, dual energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often play a complementary role in the study of osteoporosis and sarcopenia, depicting different aspects of the same pathology. This paper presents the different imaging modalities currently used for the investigation of bone and muscle mass and quality in osteoporosis and sarcopenia with special emphasis on the clinical applications and limitations of each technique and with the intent to provide interesting insights into recent advances in the field of conventional imaging, novel high-resolution techniques and fracture risk.

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Effects of Three Different Testosterone Formulations in Female-to-Male Transsexual Persons

Cited by 149 publications

References 40 publications

Metabolic Effects Of Hormone Therapy In Transgender Patients

Metabolic Effects Of Hormone Therapy In Transgender Patients

Priorities for transgender medical and healthcare research

Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia

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