Effects of transcranial direct current stimulation on neural activity and functional connectivity during fear extinction

Lee, Dongha; Guiomar, Raquel; Gonçalves, Óscar F.; Almeida, Jorge; Ganho-Ávila, Ana

doi:10.1016/j.ijchp.2022.100342

Cited by 6 publications

(3 citation statements)

References 77 publications

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“…Although there are inadequate data to perform a meta-analysis on the effect of cathodal tDCS, recent neuroimaging studies suggested that offline cathodal tDCS over the dlPFC prior to extinction can affect the neural responses to the CS during the extinction phase (Ganho-Ávila et al, 2022; Lee et al, 2023). Compared with the sham group in Ganho-Avila et al (2022), the active group exhibited less activation in the prefrontal, postcentral, and paracentral regions when processing the CS+.…”

Section: Discussionmentioning

confidence: 99%

“…Compared with the sham group in Ganho-Avila et al ( 2022), the active group exhibited less activation in the prefrontal, postcentral, and paracentral regions when processing the CS+. The classification accuracy of the CS+ and CS-in the left anterior dorsal and ventral insulae and hippocampus was higher in the tDCS group than in the control group (Lee et al, 2023). Future studies might examine the effects of cathodal tDCS over the dlPFC to test the robustness of these findings.…”

Section: Effect Of Tdcs On Threat Extinction and Return Of Fear In Hu...mentioning

confidence: 92%

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The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

Lei,

Lai,

Lee

et al. 2023

Preprint

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Anxiety and fear-related disorders are among the most prevalent mental illnesses. Non-invasive brain stimulation methods such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) have been employed to modulate anxiety and fear-related symptoms, but their therapeutic effects remain inconclusive. Pavlovian conditioning and extinction are experimental analogues of exposure therapy that investigate the neural mechanisms of fear extinction and return of fear. We conducted a meta-analysis and qualitative review on the effects of tDCS and TMS on fear extinction and return of fear in non-primate animals and humans. Results show that both anodal and cathodal tDCS over the prefrontal cortex inhibit short-term contextual and cued fear retrieval in animal models. In human studies, anodal tDCS over the medial/ventromedial prefrontal cortex enhances fear extinction, whereas TMS over the dorsolateral/ventromedial prefrontal cortex inhibits return of fear. Our findings suggest the optimal non-invasive brain stimulation protocols for threat extinction in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Effect Of Tdcs On Threat Extinction and Return Of Fear In Hu...mentioning

confidence: 92%

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

Lei,

Lai,

Lee

et al. 2023

Preprint

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“…Over the past 5 years, several systematic reviews have been published discussing the efficacy of rTMS in PPD [3,4 ▪▪ ,13,20–27], demonstrating the growing interest of rTMS in PPD. Overall, TMS was used to decrease depressive symptoms in 95 pregnant women, and 315 postpartum women [23,25,28–47,48 ▪▪ ,49].…”

Section: Transcranial Magnetic Stimulation In Peripartum Depressionmentioning

confidence: 99%

Transcranial magnetic stimulation and transcranial direct current stimulation in reducing depressive symptoms during the peripartum period

Ganho-Ávila,

Sobral,

Berg

2024

Current Opinion in Psychiatry

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Purpose of the review To present the latest data on the efficacy, safety, and acceptability of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in peripartum depression (PPD), complemented by notes emerging from our clinical and research experience. Recent findings TMS and tDCS show promising results to manage mild to moderate depressive symptoms in the peripartum period. Evidence of TMS efficacy during pregnancy and the postpartum comes from two small randomized controlled trials (RCTs) with encouraging but still inconsistent results. Evidence of tDCS efficacy during pregnancy comes from one small RCT and in the postpartum the first RCT is just now being conducted and results are highly expected. The safety profile (with transient mild adverse effect to women and no known risk to the foetus/newborn) and acceptability by women seems overall good. However, the perspectives from health professionals and managers are unclear. Summary Whereas TMS accelerated protocols (e.g., more than one session/day) and shorter sessions (e.g., theta burst stimulation) could address the need for fast results in PPD, home-based tDCS systems could address accessibility issues. Currently, the evidence on the efficacy of TMS and tDCS in PPD is limited warranting further research to support stronger evidence-based clinical guidelines.

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Contemporary Approaches Toward Neuromodulation of Fear Extinction and Its Underlying Neural Circuits

Becker,

Milad

2023

Current Topics in Behavioral Neurosciences

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Effects of transcranial direct current stimulation on neural activity and functional connectivity during fear extinction

Cited by 6 publications

References 77 publications

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

The Effect of Transcranial Direct Current and Magnetic Stimulation on Fear Extinction and Return of Fear: A meta-analysis and Systematic Review

Transcranial magnetic stimulation and transcranial direct current stimulation in reducing depressive symptoms during the peripartum period

Contemporary Approaches Toward Neuromodulation of Fear Extinction and Its Underlying Neural Circuits

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