Effects of Transcranial Direct Current Stimulation (tDCS) Combined With Wrist Robot-Assisted Rehabilitation on Motor Recovery in Subacute Stroke Patients: A Randomized Controlled Trial

Mazzoleni, Stefano; Tran, Vi-Do; Dario, P.; Posteraro, Federico

doi:10.1109/tnsre.2019.2920576

Cited by 49 publications

(88 citation statements)

References 38 publications

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“…— Anodal M1 tDCS Class II studies had mixed results and used different concomitant therapies. Combining standard MPS therapy with anodal M1 tDCS accelerated pain reduction (1st week effect), but MPS therapy led to a ceiling effect at weeks 2–4 ( Sakrajai et al, 2014 ). Trigger point injections ( Choi et al, 2014 ) resulted in reduced pre-post session pain on days 2–5 in the left DLPFC tDCS group, but after the last session the DLPFC, M1, and sham groups had similar improvements.…”

Section: Introductionmentioning

confidence: 99%

Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders

Fregni

El-Hagrassy

Pacheco‐Barrios

et al. 2020

International Journal of Neuropsychopharmacology

387

242

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Background Transcranial direct current stimulation (tDCS) has shown promising clinical results, leading to increased demand for an evidence-based review on its clinical effects. Objective We convened a team of tDCS experts to conduct a systematic review of clinical trials with more than one session of stimulation testing: Pain, Parkinson’s Disease Motor Function and Cognition, Stroke Motor Function and Language, Epilepsy, Major Depressive Disorder, Obsessive-Compulsive Disorder, Tourette Syndrome, Schizophrenia and Drug Addiction. Methods Experts were asked to conduct this systematic review according to the search methodology from PRISMA guidelines. Recommendations on efficacy were categorized into: Levels A (definitely effective), B (probably effective), C (possibly effective) or no recommendation. We assessed risk of bias for all included studies to confirm whether results were driven by potentially biased studies. Results Although most of the clinical trials have been designed as proof-of-concept trials, some of the indications analyzed in this review can be considered as definitely effective (Level A) such as depression, probably effective (Level B) such as neuropathic pain, fibromyalgia, migraine, post-operative patient-controlled analgesia and pain, Parkinson´s disease (motor and cognition), stroke (motor), epilepsy, schizophrenia and alcohol addiction. Assessment of bias showed that most of the studies had low risk of biases and sensitivity analysis for bias did not change these results. Effect sizes vary from 0.01 to 0.70 and were significant in about 8 conditions, with largest effect size being in postoperative acute pain, and smaller in stroke motor recovery (nonsignificant when combined with robotic therapy). Conclusion All recommendations listed here are based on current published Pubmed-indexed data. Despite high level of evidence in some conditions, it needs to be underscored that effect sizes and duration of effects are often limited; thus, real clinical impact needs to be further determined with different study designs.

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Section: Introductionmentioning

confidence: 99%

Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders

Fregni

El-Hagrassy

Pacheco‐Barrios

et al. 2020

International Journal of Neuropsychopharmacology

387

242

View full text Add to dashboard Cite

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“…and cognitive training (Beretta et al, 2020), and explore the effects of this mixed type of intervention. Studies have shown that both tDCS and exercise (e.g., strength training) can increase the excitability of cortical (e.g., primary motor cortex, M1) as measured by the amplitude of motor-evoked potential (MEP) (Kidgell et al, 2010;Mazzoleni et al, 2019). Therefore, it is speculated that this mixed-type intervention may induce greater improvements as compared to tDCS-or exercise/training-only intervention.…”

Section: Introductionmentioning

confidence: 99%

Effects of Transcranial Direct Current Stimulation Combined With Physical Training on the Excitability of the Motor Cortex, Physical Performance, and Motor Learning: A Systematic Review

Wang

Xiao

et al. 2021

Front. Neurosci.

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Purpose: This systematic review aims to examine the efficacy of transcranial direct current stimulation (tDCS) combined with physical training on the excitability of the motor cortex, physical performance, and motor learning.Methods: A systematic search was performed on PubMed, Web of Science, and EBSCO databases for relevant research published from inception to August 2020. Eligible studies included those that used a randomized controlled design and reported the effects of tDCS combined with physical training to improve motor-evoked potential (MEP), dynamic posture stability index (DPSI), reaction time, and error rate on participants without nervous system diseases. The risk of bias was assessed by the Cochrane risk of bias assessment tool.Results: Twenty-four of an initial yield of 768 studies met the eligibility criteria. The risk of bias was considered low. Results showed that anodal tDCS combined with physical training can significantly increase MEP amplitude, decrease DPSI, increase muscle strength, and decrease reaction time and error rate in motor learning tasks. Moreover, the gain effect is significantly greater than sham tDCS combined with physical training.Conclusion: tDCS combined with physical training can effectively improve the excitability of the motor cortex, physical performance, and motor learning. The reported results encourage further research to understand further the synergistic effects of tDCS combined with physical training.

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“…General Introduction 3. used to reflect smoothness of the reaching movement, for example, jerk (Mazzoleni et al, 2019), speed metric, mean arrest period ratio, peaks metric, tent metric (Rohrer et al, 2002), smoothness Index (Pila et al, 2017) etc.…”

Section: Upper Extremitymentioning

confidence: 99%

“…4. used to measure the accuracy or efficiency in performing the reaching movement, for example, active range of motion (Duret et al, 2019), hand path ratio (Palermo et al, 2018), average squared Mahalanobis distance (Cortes et al, 2017), distance Index, Accuracy Index (Pila et al, 2017), initial direction error, initial distance ratio (Semrau et al, 2015), quality index (Mazzoleni et al, 2018), Movement Error (Mazzoleni et al, 2019) etc.…”

Section: Upper Extremitymentioning

confidence: 99%

“…. These metrics were shown to change over time post-stroke, mainly in the early sub-acute phase (Colombo et al, 2013;Duret et al, 2016;Mazzoleni et al, 2019Mazzoleni et al, , 2018Metrot et al, 2013;Palermo et al, 2018;van Kordelaar et al, 2014;Yoo and Kim, 2015). Studies showed varying outcomes for the longitudinal association between peaks metric and FM-UE (Rohrer et al, 2002;van Dokkum et al, 2014).…”

Section: 2)mentioning

confidence: 99%

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Moving on: measuring movement remotely after stroke

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Irfan²

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Effects of Transcranial Direct Current Stimulation (tDCS) Combined With Wrist Robot-Assisted Rehabilitation on Motor Recovery in Subacute Stroke Patients: A Randomized Controlled Trial

Cited by 49 publications

References 38 publications

Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders

Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders

Effects of Transcranial Direct Current Stimulation Combined With Physical Training on the Excitability of the Motor Cortex, Physical Performance, and Motor Learning: A Systematic Review

Moving on: measuring movement remotely after stroke

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