Effects of treadmill exercise on cognitive functions and anxiety-related behaviors in ovariectomized diabetic rats

Mohammadi, Moslem; Zare, Zohreh

doi:10.1016/j.physbeh.2020.113021

Cited by 18 publications

(6 citation statements)

References 45 publications

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“…In this study, we found that FTS•B could reduce cognitive impairment in menopausal diabetic mice, inhibit inflammatory factors, and reduce synaptic dysfunction, which effectively improve their cognitive function. A large number of studies have shown that DACI can cause changes in animal behavior; so, behavioral experiments can be used as an important detection method in the study of diabetic encephalopathy (Yan et al, 2018;Tang et al, 2019;Mohammadi and Zare, 2020;Piatkowska-Chmiel et al, 2022). Piatkowska-Chmiel et al administered fructose solution + STZ intraperitoneal injection for 4 weeks to induce diabetes in CD-1 mice.…”

Section: Discussionmentioning

confidence: 99%

“…A large number of studies have shown that DACI can cause changes in animal behavior; so, behavioral experiments can be used as an important detection method in the study of diabetic encephalopathy ( Yan et al, 2018 ; Tang et al, 2019 ; Mohammadi and Zare, 2020 ; Piatkowska-Chmiel et al, 2022 ). Piatkowska-Chmiel et al administered fructose solution + STZ intraperitoneal injection for 4 weeks to induce diabetes in CD-1 mice.…”

Section: Discussionmentioning

confidence: 99%

“…GAPDH was used as an endogenous control. The changes of relative mRNA transcript levels were reported using the 2 [-Delta C(T)] method as previously described ( Mohammadi and Zare, 2020 ). The experiment was repeated at least three times to ensure accuracy.…”

Section: Methodsmentioning

confidence: 99%

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Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice

Nan

Sun

et al. 2022

Front. Aging Neurosci.

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BackgroundDiabetes-associated cognitive impairment (DACI) is a common complication of diabetes, and studies have shown that DACI is more severe in postmenopausal patients with diabetes. Forsythoside B (FTS⋅B) can inhibit inflammation and reduce synaptic dysfunction, which can improve cognitive function. However, it has not been confirmed whether FTS⋅B has a reversing or retarding effect on postmenopausal diabetic encephalopathy.MethodsSeven days after bilateral ovariectomy (OVX) or sham surgery, adult female C57 mice (n = 15/group) received intraperitoneal injection of streptozotocin (60 mg/kg/day/L) and citrate buffer for 5 consecutive days to induce diabetes mellitus (DM). Fourteen days later, ovariectomized diabetic mice were given intraperitoneal injection of FTS⋅B (100, 150 mg/kg/day/L) and subcutaneous injection of 17β-estradiol (1 mg/kg) for 8 weeks [OVX + DM + low-FTS⋅B group (L-F), OVX + DM + high-FTS⋅B group (H-F), and OVX + DM + 17β-estradiol (ER)]. In addition, the following control groups were defined: Sham, OVX, DM, and OVX + DM (O + D). Fasting plasma glucose, body weight and blood insulin levels were determined in each group of mice. Next, their cognitive function was tested through behavioral experiments. Hematoxylin & eosin (H&E) and Nissl staining were used to detect the morphological changes in the hippocampus. The aggregation of amyloid beta (Aβ) and the hyperaggregation of p-tau were assessed by immunohistochemistry. Interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), brain-derived neurotrophic factor (BDNF), post-synaptic density-95 (PSD-95), synaptophysin, and synapsin-1 expression in the hippocampus was detected by real-time polymerase chain reaction (RT-PCR) and western blot analysis.ResultsFTS⋅B can decrease fasting glucose and blood insulin level. Behavioral results showed that cognitive decline was the most severe in the O + D group, and the ER, L-F, and H-F groups revised the cognitive decline. Compared to the O + D group, more normal morphology, which has obvious nucleoli and clear nuclear membrane, was observed by H&E and Nissl staining in the ER, L-F, and H-F groups. FTS⋅B alleviated DACI by reducing the aggregation of Aβ and the hyperaggregation of p-tau in the hippocampus. Moreover, the protein and mRNA expression showed that FTS⋅B not only inhibited inflammation by decreasing IL-1β, IL-6, and TNF-α but also modulated synaptic plasticity by increasing BDNF, PSD-95, synaptophysin, and synapsin-1.ConclusionThese results suggest that FTS⋅B may be a novel therapeutic target for postmenopausal diabetic encephalopathy treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice

Nan

Sun

et al. 2022

Front. Aging Neurosci.

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“…On the last day (long-term spatial memory phase, probe test), the platform was removed from the target quadrant, and the rats were released from the quadrant in front of the target quadrant into the water, allowing them to search for the platform for 60 sec. Parameters recorded for this step were time spent, the traveled distance, and the number of crossing (Frequency) in the target zone (45). At the end of the probe trial, a visible platform test was conducted to reveal any possibility of intervention with sensory and motor coordination or motivation.…”

Section: Morris Water Mazementioning

confidence: 99%

Controversial Effects of Diverse Types of Toxoplasma gondii on the Anxiety-like Behavior and Cognitive Impairments in the Animal Model of Alzheimer's Disease

Galeh

Ghazvini

Sarvi

et al. 2022

Iran J Psychiatry Behav Sci

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Background: Toxoplasma gondii is a neurotropic parasite with lifelong persistence in the host brain. Many researchers suggested toxoplasmosis as a risk factor for the development of Alzheimer's disease (AD); however, the link between them has not been fully elucidated. Objectives: The present study was designed to investigate the effects of chronic toxoplasmosis infection with Types I (RH), II (PRU), and III (VEG) strains alone and in combination on cognitive impairment in Alzheimer's rat model. Methods: Seven months after the inoculation of the strains, AD was induced bilaterally in rats by injecting human amyloid beta 1-42 (Aβ1-42) peptide into the brain hippocampus. Behavioral tests, including the Morris water maze (MWM) and elevated plus maze (EPM) were conducted 10 days after the AD induction. Results: Our findings showed that chronic infection with RH strain increased anxiety-like behavior in the Alzheimer's rats in the EPM. In agreement with EPM findings, rats infected with the RH strain exacerbated spatial learning disorders in the MWM test; however, it did not affect the spatial memory. Conversely, infection with the PRU strain significantly enhanced spatial learning without being able to improve memory impairment in the Alzheimer's rat model. Improvement in spatial learning and memory impairments were also observed in rats infected with PRU and VEG strains in combination. Conclusions: Taken together, our findings suggest that chronic infection with PRU strain, as well as PRU and VEG strains in combination, can significantly improve cognitive deficits induced by Aβ1-42 in Alzheimer's rats, while RH strain plays a detrimental role in AD pathogenesis.

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“…Furthermore, exercise has been recognized as an effective strategy for managing diabetes and its complications. Regular physical activity, such as treadmill exercise, has been found to improve the glycemic control, enhance the antioxidant capacity, and ameliorate the testicular dysfunction in diabetic animals (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Carvacrol Plus Treadmill Exercise on Testis Structure and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

Bradaran Bagheri,

Shadman,

Khaki

2023

Crescent J Med Biol Sci

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Objectives: This study aimed to evaluate the effect of carvacrol and treadmill exercise on oxidative stress and testis structure in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: In this experimental study, the diabetes was induced using a single intraperitoneal (IP) injection of STZ (50 mg/kg). The rats were assigned to five groups, namely a control group, a diabetic control group, a diabetic group receiving daily carvacrol at a dose of 75 mg/kg, diabetic groups performing treadmill exercise, and a diabetic group performing daily treadmill exercise and receiving carvacrol. After covering the treatment period, all rats were anesthetized and their blood sample were taken. Then the serum levels of oxidative stress markers were measured, the testicles and epididymis were removed, and the sperm parameters were assessed. Results: The treatment of diabetic rats with carvacrol and treadmill exercise effectively improved testis tissue damage, sperm parameters, glucose, and insulin plasma levels (P=0.001). In diabetic rats, the level of malondialdehyde (MDA) increased while the activity of superoxide dismutase (SOD) and catalase (CAT) enzymes decreased in the testes tissue (P=0.001). However, when carvacrol administration (75 mg/kg) was combined with treadmill exercise, these parameters were significantly rectified (P<0.05). Conclusion: In sum, administering carvacrol and performing treadmill exercise were effective in improving the sperm parameters and testicular oxidative damage caused by diabetes.

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Effects of treadmill exercise on cognitive functions and anxiety-related behaviors in ovariectomized diabetic rats

Cited by 18 publications

References 45 publications

Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice

Forsythoside B ameliorates diabetic cognitive dysfunction by inhibiting hippocampal neuroinflammation and reducing synaptic dysfunction in ovariectomized mice

Controversial Effects of Diverse Types of Toxoplasma gondii on the Anxiety-like Behavior and Cognitive Impairments in the Animal Model of Alzheimer's Disease

The Effect of Carvacrol Plus Treadmill Exercise on Testis Structure and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

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