Effects of two different hydroxyethyl starch solutions (HES200/0.5 vs. HES130/0.4) on the expression of platelet membrane glycoprotein

Chen, G.; Yan, Mengmeng; Lu, Qinghua; Gong, Ming

doi:10.1111/j.1399-6576.2006.01138.x

Cited by 17 publications

(11 citation statements)

References 27 publications

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“…Nevertheless, HES 130 produced a not clinically significant platelet alteration. Similar results were reported for minor elective surgery [62].…”

Section: Clinical Evidencesupporting

confidence: 90%

“…In a retrospective study on transplanted kidneys from brain-dead donors, Legendre et al [66] found an 80% rate of renal injury after the infusion of HES 200/0 [62]. However, these anatomic alterations did not cause adverse effects in kidney transplant recipients.…”

Section: Clinical Evidencementioning

confidence: 97%

“…All colloids can induce kidney injury. Some studies showed an increased incidence of kidney dysfunction in patients treated with high MMW and high MS HES [62,63].…”

Section: Nephrotoxicitymentioning

confidence: 99%

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How to Maintain and Restore Fluid Balance: Colloids

Fries¹,

Benedetto

2013

Body Fluid Management

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“…Nevertheless, HES 130 produced a not clinically significant platelet alteration. Similar results were reported for minor elective surgery [62].…”

Section: Clinical Evidencesupporting

confidence: 90%

Section: Clinical Evidencementioning

confidence: 97%

See 1 more Smart Citation

How to Maintain and Restore Fluid Balance: Colloids

Fries¹,

Benedetto

2013

Body Fluid Management

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“…Blood loss and transfusion requirements are significantly reduced in major surgery when HES 130 is administered compared to HES 200 [21,22]. Furthermore, platelet dysfunction exhibits a faster recovery after the infusion of HES 130 compared to HES 200 [23]. However, little is known about the effects of the two different HES solutions on oxidative stress and the inflammatory response following HS/R.…”

Section: Discussionmentioning

confidence: 99%

Effects of synthetic colloids on oxidative stress and inflammatory response in hemorrhagic shock: comparison of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin

et al. 2013

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IntroductionThis study compared the effects of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin on oxidative stress and the inflammatory response in a rodent hemorrhagic shock model.MethodsSodium pentobarbital-anesthetized adult male Wistar rats (200 g to 220 g) were subjected to a severe volume-controlled hemorrhage using arterial blood withdrawal (30 mL/kg to 33 mL/kg) and resuscitated with a colloid solution at the same volume as blood withdrawal (hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, or succinylated gelatin). Arterial blood gas parameters were monitored. Malondialdehyde (MDA) content and myeloperoxidase (MPO) activity in the liver, lungs, intestine, and brain were measured two hours after resuscitation. The levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 in the intestine were also measured.ResultsInfusions of hydroxyethyl starch 130/0.4, but not hydroxyethyl starch 200/0.5 or succinylated gelatin, significantly reduced MDA levels and MPO activity in the liver, intestine, lungs and brain, and it also inhibited the production of TNF-α in the intestine two hours after resuscitation. However, no significant difference between hydroxyethyl starch 200/0.5 and succinylated gelatin was observed.ConclusionsHydroxyethyl starch 130/0.4, but not hydroxyethyl starch 200/0.5 or succinylated gelatin, treatment after hemorrhagic shock ameliorated oxidative stress and the inflammatory response in this rat model. No significant differences were observed after hydroxyethyl starch 200/0.5 or succinylated gelatin administration at doses of approximately 33 mL/kg.

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“…While 10 mL/kg HES 130/0.4 had no platelet inhibiting effects, 37 20 mL/kg inhibited the expression of platelet membrane GP Ib‐IX (CD42b), GP IIb‐IIIa (CD41/61) and P‐selectin (CD62P) on ADP‐stimulated platelets 41 . Platelet function recovered within 6 hours after infusions of HES 130/0.4 but not after HES 200/0.5 41 …”

Section: Decrease In Platelet Functionmentioning

confidence: 99%

Effects of hydroxyethyl starches on hemostasis

Kozek‐Langenecker

Scharbert

2007

Transfus Alt Transfus Med

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SUMMARY Hydroxyethyl starch (HES) solutions are frequently used colloidal plasma expanders which are indicated to restore and maintain intravascular volume and to improve tissue perfusion. The development of HES solutions since their introduction into clinical practice has centered on designing starch molecules with an increased oncotic pressure and hemodynamic efficacy while minimizing the risk of adverse reactions such as anticoagulant effects. This article reviews specific anticoagulant side effects of various HES generations, including hetastarch, pentastarch and tetrastarch. Slowly degradable HES solutions have a more pronounced impact on coagulation than rapidly degradable HES. The decrease in factor VIII and von Willebrand factor may be due to complex binding to HES macromolecules and accelerated elimination. Extracellular coating of platelets by HES molecules results in an inhibition of platelet aggregation and adhesion. Thrombin–fibrin interaction, fibrin polymerization, activation of factor XIII, as well as clot resistance to fibrinolytic degradation is reduced in the presence of HES. Balanced salt solutions cause fewer coagulation abnormalities than HES dissolved in saline. Possible approaches to reverse HES‐induced coagulopathy may include the administration of desmopressin, fibrinogen and factor XIII concentrates. Hetastarch attenuates hypercoagulability in patients at risk for thrombotic episodes and increases perioperative bleeding, while blood loss and transfusion requirements were not different in patients exposed to tetrastarch compared with gelatin or albumin. Accordingly, tetrastarch appears to be a suitable volume expander in the routine perioperative setting because of adequate volume efficacy and minimal risk for hemostatic derangements. Contraindications and maximum daily doses need to be acknowledged.

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Effects of two different hydroxyethyl starch solutions (HES200/0.5 vs. HES130/0.4) on the expression of platelet membrane glycoprotein

Cited by 17 publications

References 27 publications

How to Maintain and Restore Fluid Balance: Colloids

How to Maintain and Restore Fluid Balance: Colloids

Effects of synthetic colloids on oxidative stress and inflammatory response in hemorrhagic shock: comparison of hydroxyethyl starch 130/0.4, hydroxyethyl starch 200/0.5, and succinylated gelatin

Effects of hydroxyethyl starches on hemostasis

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